MIGA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIGA2_HUMAN
• UniProt AC: Q7L4E1
• Protein Name: Mitoguardin 2 {ECO:0000303|PubMed:26711011}
• Gene Name: MIGA2 {ECO:0000303|PubMed:26711011, ECO:0000312|HGNC:HGNC:23621}
• Organism: Homo sapiens (Human).
• Sequence Length: 593
• Subcellular Localization: Mitochondrion outer membrane ; Multi-pass membrane protein .
• Protein Description: Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD..
• Protein Sequence: MAFRRAEGTSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRRKKQVGPEMGGEQLGTVPLPILLARKVPSVKKGYSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSVASMMAVNSSSPTAACSGLWDARGMEESLTTSDGNAESLYMQGMELFEEALQKWEQALSVGQRGDSGSTPMPRDGLRNPETASEPLSEPESQRKEFAEKLESLLHRAYHLQEEFGSTFPADSMLLDLERTLMLPLTEGSLRLRADDEDSLTSEDSFFSATELFESLQTGDYPIPLSRPAAAYEEALQLVKEGRVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEDKSNQLFFGKVGRQMVTGLMTKAEKSPKGFLESYEEMLSYALRPETWATTRLELEGRGVVCMSFFDIVLDFILMDAFEDLENPPASVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLAEVCAFFKHQIVQYLRDMFDLDNVRYTSLPALADDILQLSRRRSEILLGYLGVPAASSAGVNGALPRENGPLGELQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	TFGQSAFSQLRLTPG CCCHHHHHHHCCCHH		24719451
86	Phosphorylation	MGGEQLGTVPLPILL CCCCCCCCCCHHHHH		29514088
96	Methylation	LPILLARKVPSVKKG HHHHHHCCCCCCCCC		-
99	Phosphorylation	LLARKVPSVKKGYSS HHHCCCCCCCCCCCC		23403867
111	Phosphorylation	YSSRRVQSPSSKSND CCCCCCCCCCCCCCC		28985074
116	Phosphorylation	VQSPSSKSNDTLSGI CCCCCCCCCCCCCCC		22199227
119	Phosphorylation	PSSKSNDTLSGISSI CCCCCCCCCCCCCCC		25159151
121	Phosphorylation	SKSNDTLSGISSIEP CCCCCCCCCCCCCCC		29083192
124	Phosphorylation	NDTLSGISSIEPSKH CCCCCCCCCCCCCCC		25159151
125	Phosphorylation	DTLSGISSIEPSKHS CCCCCCCCCCCCCCC		25159151
132	Phosphorylation	SIEPSKHSGSSHSVA CCCCCCCCCCCCCHH		28270605
134	Phosphorylation	EPSKHSGSSHSVASM CCCCCCCCCCCHHHH		28270605
135	Phosphorylation	PSKHSGSSHSVASMM CCCCCCCCCCHHHHH		28270605
137	Phosphorylation	KHSGSSHSVASMMAV CCCCCCCCHHHHHCC		28270605
140	Phosphorylation	GSSHSVASMMAVNSS CCCCCHHHHHCCCCC		28270605
146	Phosphorylation	ASMMAVNSSSPTAAC HHHHCCCCCCCCHHH		29449344
147	Phosphorylation	SMMAVNSSSPTAACS HHHCCCCCCCCHHHC		28270605
148	Phosphorylation	MMAVNSSSPTAACSG HHCCCCCCCCHHHCC		28270605
150	Phosphorylation	AVNSSSPTAACSGLW CCCCCCCCHHHCCCC		28270605
154	Phosphorylation	SSPTAACSGLWDARG CCCCHHHCCCCCCCC		28270605
196	Phosphorylation	QKWEQALSVGQRGDS HHHHHHHHHCCCCCC		28348404
203	Phosphorylation	SVGQRGDSGSTPMPR HHCCCCCCCCCCCCC		25849741
205	Phosphorylation	GQRGDSGSTPMPRDG CCCCCCCCCCCCCCC		29255136
206	Phosphorylation	QRGDSGSTPMPRDGL CCCCCCCCCCCCCCC		29255136
218	Phosphorylation	DGLRNPETASEPLSE CCCCCCCCCCCCCCC		23927012
220	Phosphorylation	LRNPETASEPLSEPE CCCCCCCCCCCCCCH		29255136
224	Phosphorylation	ETASEPLSEPESQRK CCCCCCCCCCHHHHH		29255136
228 (in isoform 2)	Phosphorylation	-		24260401
228	Phosphorylation	EPLSEPESQRKEFAE CCCCCCHHHHHHHHH		29255136
239	Phosphorylation	EFAEKLESLLHRAYH HHHHHHHHHHHHHHH		23312004
254	Phosphorylation	LQEEFGSTFPADSML HHHHHCCCCCCHHHH		30576142
267	Phosphorylation	MLLDLERTLMLPLTE HHHHHHHHHEEECCC		23403867
273	Phosphorylation	RTLMLPLTEGSLRLR HHHEEECCCCCEEEC		29255136
276	Phosphorylation	MLPLTEGSLRLRADD EEECCCCCEEECCCC		19664994
286	Phosphorylation	LRADDEDSLTSEDSF ECCCCCCCCCCCCCC		17081983
288	Phosphorylation	ADDEDSLTSEDSFFS CCCCCCCCCCCCCCC		17081983
289	Phosphorylation	DDEDSLTSEDSFFSA CCCCCCCCCCCCCCH		17081983
292	Phosphorylation	DSLTSEDSFFSATEL CCCCCCCCCCCHHHH		17081983
295	Phosphorylation	TSEDSFFSATELFES CCCCCCCCHHHHHHH		17081983
297	Phosphorylation	EDSFFSATELFESLQ CCCCCCHHHHHHHHC		17081983
342 (in isoform 3)	Phosphorylation	-		25262027
346 (in isoform 3)	Phosphorylation	-		25262027
352	Ubiquitination	SDQDFLAKLHCVRQA CCHHHHHHHHHHHHH		-
382	Phosphorylation	KVGRQMVTGLMTKAE CHHHHHHHHHHHHHH		22210691
386	Phosphorylation	QMVTGLMTKAEKSPK HHHHHHHHHHHHCCC		22210691
391	Phosphorylation	LMTKAEKSPKGFLES HHHHHHHCCCCHHHH		24706070
561	Phosphorylation	LQLSRRRSEILLGYL HHHHHHHHHHHHHHH		24247654

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIGA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIGA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIGA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBB_HUMAN	UBB	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
NIF3L_HUMAN	NIF3L1	physical	28514442
S27A2_HUMAN	SLC27A2	physical	28514442
HSP72_HUMAN	HSPA2	physical	28514442
UBR4_HUMAN	UBR4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.