dbPTM

SELW_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SELW_HUMAN
UniProt AC	P63302
Protein Name	Selenoprotein W {ECO:0000303\|PubMed:27645994, ECO:0000303\|PubMed:9256076}
Gene Name	SELENOW {ECO:0000303\|PubMed:27645994, ECO:0000312\|HGNC:HGNC:10752}
Organism	Homo sapiens (Human).
Sequence Length	87
Subcellular Localization	Cytoplasm.
Protein Description	Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity)..
Protein Sequence	MALAVRVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAALAQG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Ubiquitination	KYLQLKKKLEDEFPG HHHHHHHHHHHCCCC	56.36	30230243
37	S-glutathionyl cysteine	FPGRLDICGEGTPQA CCCCCEECCCCCCCC	3.97	-
37	Glutathionylation	FPGRLDICGEGTPQA CCCCCEECCCCCCCC	3.97	-
59	Phosphorylation	VAGKLIHSKKKGDGY ECCEEEECCCCCCCC	38.89	26074081
66	Phosphorylation	SKKKGDGYVDTESKF CCCCCCCCCCCHHHH	10.41	23403867
69	Phosphorylation	KGDGYVDTESKFLKL CCCCCCCCHHHHHHH	31.92	26074081
71	Phosphorylation	DGYVDTESKFLKLVA CCCCCCHHHHHHHHH	30.69	26074081
75	Acetylation	DTESKFLKLVAAIKA CCHHHHHHHHHHHHH	44.01	30592315

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SELW_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SELW_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SELW_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SELW_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SELW_HUMAN

Related Literatures of Post-Translational Modification