HDHD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HDHD3_HUMAN
• UniProt AC: Q9BSH5
• Protein Name: Haloacid dehalogenase-like hydrolase domain-containing protein 3
• Gene Name: HDHD3
• Organism: Homo sapiens (Human).
• Sequence Length: 251
• Protein Sequence: MAHRLQIRLLTWDVKDTLLRLRHPLGEAYATKARAHGLEVEPSALEQGFRQAYRAQSHSFPNYGLSHGLTSRQWWLDVVLQTFHLAGVQDAQAVAPIAEQLYKDFSHPCTWQVLDGAEDTLRECRTRGLRLAVISNFDRRLEGILGGLGLREHFDFVLTSEAAGWPKPDPRIFQEALRLAHMEPVVAAHVGDNYLCDYQGPRAVGMHSFLVVGPQALDPVVRDSVPKEHILPSLAHLLPALDCLEGSTPGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Acetylation	RLLTWDVKDTLLRLR EEEECCHHHHHHHHH	42.39	19608861
15	Succinylation	RLLTWDVKDTLLRLR EEEECCHHHHHHHHH	42.39	-
15	Ubiquitination	RLLTWDVKDTLLRLR EEEECCHHHHHHHHH	42.39	19608861
15	Malonylation	RLLTWDVKDTLLRLR EEEECCHHHHHHHHH	42.39	26320211
15	Succinylation	RLLTWDVKDTLLRLR EEEECCHHHHHHHHH	42.39	27452117
32	Ubiquitination	LGEAYATKARAHGLE HHHHHHHHHHHCCCC	27.92	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HDHD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HDHD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HDHD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCH2_HUMAN	TRIP13	physical	19060904
PREP_HUMAN	PITRM1	physical	26344197
MTD2L_HUMAN	MTHFD2L	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-15, AND MASS SPECTROMETRY.
PubMed: 19608861