| UniProt ID | 5NT3B_HUMAN | |
|---|---|---|
| UniProt AC | Q969T7 | |
| Protein Name | 7-methylguanosine phosphate-specific 5'-nucleotidase {ECO:0000305|PubMed:23223233} | |
| Gene Name | NT5C3B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 300 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. [PubMed: 23223233] | |
| Protein Sequence | MAEEVSTLMKATVLMRQPGRVQEIVGALRKGGGDRLQVISDFDMTLSRFAYNGKRCPSSYNILDNSKIISEECRKELTALLHHYYPIEIDPHRTVKEKLPHMVEWWTKAHNLLCQQKIQKFQIAQVVRESNAMLREGYKTFFNTLYHNNIPLFIFSAGIGDILEEIIRQMKVFHPNIHIVSNYMDFNEDGFLQGFKGQLIHTYNKNSSACENSGYFQQLEGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDSYDIVLEKDETLDVVNGLLQHILCQGVQLEMQGP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MAEEVSTLMKATVL -CHHHHHHHHHHHHH | 27174698 | ||
| 10 | Methylation | EEVSTLMKATVLMRQ HHHHHHHHHHHHHCC | 115974265 | ||
| 12 | Phosphorylation | VSTLMKATVLMRQPG HHHHHHHHHHHCCCC | 27174698 | ||
| 58 | Phosphorylation | YNGKRCPSSYNILDN CCCCCCCCCCCCCCC | 28152594 | ||
| 59 | Phosphorylation | NGKRCPSSYNILDNS CCCCCCCCCCCCCCC | 28152594 | ||
| 60 | Phosphorylation | GKRCPSSYNILDNSK CCCCCCCCCCCCCCC | 28152594 | ||
| 78 | Phosphorylation | EECRKELTALLHHYY HHHHHHHHHHHHHHC | - | ||
| 84 | Phosphorylation | LTALLHHYYPIEIDP HHHHHHHHCCCCCCC | - | ||
| 85 | Phosphorylation | TALLHHYYPIEIDPH HHHHHHHCCCCCCCC | - | ||
| 94 | Phosphorylation | IEIDPHRTVKEKLPH CCCCCCCCHHHHCHH | - | ||
| 117 | Ubiquitination | HNLLCQQKIQKFQIA HHHHHHHHHHHHHHH | 29967540 | ||
| 248 | Acetylation | VPGVQNILKIGFLND CCCHHHHHHHCCCCH | - | ||
| 256 | Acetylation | KIGFLNDKVEERRER HHCCCCHHHHHHHHH | 19608861 | ||
| 256 | Ubiquitination | KIGFLNDKVEERRER HHCCCCHHHHHHHHH | 19608861 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of 5NT3B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of 5NT3B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of 5NT3B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of 5NT3B_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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