C42S1_HUMAN - dbPTM
C42S1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID C42S1_HUMAN
UniProt AC Q9NRR8
Protein Name CDC42 small effector protein 1
Gene Name CDC42SE1
Organism Homo sapiens (Human).
Sequence Length 79
Subcellular Localization Cytoplasm, cytoskeleton. Cell membrane
Lipid-anchor. Recruited to the activated TCR prior actin polymerization.
Protein Description Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages..
Protein Sequence MSEFWHKLGCCVVEKPQPKKKRRRIDRTMIGEPMNFVHLTHIGSGEMGAGDGLAMTGAVQEQMRSKGNRDRPWSNSRGL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
10S-palmitoylationEFWHKLGCCVVEKPQ
HHHHHHCCEEECCCC
2.0029575903
11S-palmitoylationFWHKLGCCVVEKPQP
HHHHHCCEEECCCCC
3.4929575903
15UbiquitinationLGCCVVEKPQPKKKR
HCCEEECCCCCCCCC
37.0323000965
19UbiquitinationVVEKPQPKKKRRRID
EECCCCCCCCCCCCC
66.7223000965
20UbiquitinationVEKPQPKKKRRRIDR
ECCCCCCCCCCCCCH
59.1923000965
21UbiquitinationEKPQPKKKRRRIDRT
CCCCCCCCCCCCCHH
58.2123000965
44PhosphorylationVHLTHIGSGEMGAGD
EEEEEECCCCCCCCC
30.8627251275
56PhosphorylationAGDGLAMTGAVQEQM
CCCCCHHHHHHHHHH
19.1722210691
65PhosphorylationAVQEQMRSKGNRDRP
HHHHHHHHCCCCCCC
39.3022210691
74PhosphorylationGNRDRPWSNSRGL--
CCCCCCCCCCCCC--
27.8422167270
76PhosphorylationRDRPWSNSRGL----
CCCCCCCCCCC----
23.3922167270

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of C42S1_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of C42S1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of C42S1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MIPEP_HUMANMIPEPphysical
28514442
IF2P_HUMANEIF5Bphysical
28514442
CDC42_HUMANCDC42physical
28514442
BTBD1_HUMANBTBD1physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of C42S1_HUMAN

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Related Literatures of Post-Translational Modification

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