| UniProt ID | CIPC_HUMAN | |
|---|---|---|
| UniProt AC | Q9C0C6 | |
| Protein Name | CLOCK-interacting pacemaker | |
| Gene Name | CIPC | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 399 | |
| Subcellular Localization | Nucleus . Cytoplasm, cytosol . Predominantly localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S boundary, partially translocated to the cytosol. | |
| Protein Description | Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock.. | |
| Protein Sequence | MERKNPSRESPRRLSAKVGKGTEMKKVARQLGMAAAESDKDSGFSDGSSECLSSAEQMESEDMLSALGWSREDRPRQNSKTAKNAFPTLSPMVVMKNVLVKQGSSSSQLQSWTVQPSFEVISAQPQLLFLHPPVPSPVSPCHTGEKKSDSRNYLPILNSYTKIAPHPGKRGLSLGPEEKGTSGVQKKICTERLGPSLSSSEPTKAGAVPSSPSTPAPPSAKLAEDSALQGVPSLVAGGSPQTLQPVSSSHVAKAPSLTFASPASPVCASDSTLHGLESNSPLSPLSANYSSPLWAAEHLCRSPDIFSEQRQSKHRRFQNTLVVLHKSGLLEITLKTKELIRQNQATQVELDQLKEQTQLFIEATKSRAPQAWAKLQASLTPGSSNTGSDLEAFSDHPAI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Ubiquitination | RLSAKVGKGTEMKKV HHHHHCCCCHHHHHH | - | ||
| 25 | Ubiquitination | VGKGTEMKKVARQLG CCCCHHHHHHHHHHH | - | ||
| 26 | Ubiquitination | GKGTEMKKVARQLGM CCCHHHHHHHHHHHH | - | ||
| 70 | Phosphorylation | MLSALGWSREDRPRQ HHHHHCCCCCCCCCC | 24719451 | ||
| 81 | Phosphorylation | RPRQNSKTAKNAFPT CCCCCCHHHHHHCCC | - | ||
| 83 | Ubiquitination | RQNSKTAKNAFPTLS CCCCHHHHHHCCCCC | - | ||
| 88 | Phosphorylation | TAKNAFPTLSPMVVM HHHHHCCCCCHHEEE | 18767875 | ||
| 90 | Phosphorylation | KNAFPTLSPMVVMKN HHHCCCCCHHEEEEE | 18767875 | ||
| 173 | Phosphorylation | HPGKRGLSLGPEEKG CCCCCCCCCCCCCCC | - | ||
| 179 | Acetylation | LSLGPEEKGTSGVQK CCCCCCCCCCCCHHH | 19667067 | ||
| 181 | Phosphorylation | LGPEEKGTSGVQKKI CCCCCCCCCCHHHHH | - | ||
| 182 | Phosphorylation | GPEEKGTSGVQKKIC CCCCCCCCCHHHHHC | - | ||
| 196 | Phosphorylation | CTERLGPSLSSSEPT CHHCCCCCCCCCCCC | 23312004 | ||
| 198 | Phosphorylation | ERLGPSLSSSEPTKA HCCCCCCCCCCCCCC | 23312004 | ||
| 199 | Phosphorylation | RLGPSLSSSEPTKAG CCCCCCCCCCCCCCC | 23312004 | ||
| 200 | Phosphorylation | LGPSLSSSEPTKAGA CCCCCCCCCCCCCCC | 23312004 | ||
| 203 | Phosphorylation | SLSSSEPTKAGAVPS CCCCCCCCCCCCCCC | 23312004 | ||
| 210 | Phosphorylation | TKAGAVPSSPSTPAP CCCCCCCCCCCCCCC | 30266825 | ||
| 211 | Phosphorylation | KAGAVPSSPSTPAPP CCCCCCCCCCCCCCC | 30266825 | ||
| 213 | Phosphorylation | GAVPSSPSTPAPPSA CCCCCCCCCCCCCCC | 30266825 | ||
| 214 | Phosphorylation | AVPSSPSTPAPPSAK CCCCCCCCCCCCCCH | 26657352 | ||
| 219 | Phosphorylation | PSTPAPPSAKLAEDS CCCCCCCCCHHHCCH | 30108239 | ||
| 233 | Phosphorylation | SALQGVPSLVAGGSP HHHCCCCCHHCCCCC | 23312004 | ||
| 239 | Phosphorylation | PSLVAGGSPQTLQPV CCHHCCCCCCCCCCC | 25159151 | ||
| 242 | Phosphorylation | VAGGSPQTLQPVSSS HCCCCCCCCCCCCHH | 23312004 | ||
| 278 | Phosphorylation | STLHGLESNSPLSPL CHHCCCCCCCCCCCC | 28348404 | ||
| 280 | Phosphorylation | LHGLESNSPLSPLSA HCCCCCCCCCCCCCC | 28348404 | ||
| 283 | Phosphorylation | LESNSPLSPLSANYS CCCCCCCCCCCCCCC | 28348404 | ||
| 302 | Phosphorylation | AAEHLCRSPDIFSEQ HHHHHHCCCCCCCHH | 21815630 | ||
| 312 | Phosphorylation | IFSEQRQSKHRRFQN CCCHHHHHHHHHHCC | - | ||
| 320 | Phosphorylation | KHRRFQNTLVVLHKS HHHHHCCEEEEEECC | - | ||
| 354 | Ubiquitination | QVELDQLKEQTQLFI HHHHHHHHHHHHHHH | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CIPC_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CIPC_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CIPC_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CLOCK_HUMAN | CLOCK | physical | 23555304 | |
| CSK2B_HUMAN | CSNK2B | physical | 23555304 | |
| DEC1_HUMAN | DEC1 | physical | 23555304 | |
| RORG_HUMAN | RORC | physical | 23555304 | |
| ZMYM4_HUMAN | ZMYM4 | physical | 26186194 | |
| CLOCK_HUMAN | CLOCK | physical | 26186194 | |
| CLOCK_HUMAN | CLOCK | physical | 28514442 | |
| ZMYM4_HUMAN | ZMYM4 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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