| UniProt ID | MYDGF_HUMAN | |
|---|---|---|
| UniProt AC | Q969H8 | |
| Protein Name | Myeloid-derived growth factor {ECO:0000303|PubMed:25581518, ECO:0000312|HGNC:HGNC:16948} | |
| Gene Name | MYDGF {ECO:0000312|HGNC:HGNC:16948} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 173 | |
| Subcellular Localization | Secreted . Endoplasmic reticulum-Golgi intermediate compartment . Secreted into blood plasma. | |
| Protein Description | Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis. [PubMed: 25581518] | |
| Protein Sequence | MAAPSGGWNGVGASLWAALLLGAVALRPAEAVSEPTTVAFDVRPGGVVHSFSHNVGPGDKYTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGKSYLYFTQFKAEVRGAEIEYAMAYSKAAFERESDVPLKTEEFEVTKTAVAHRPGAFKAELSKLVIVAKASRTEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 37 | O-linked_Glycosylation | EAVSEPTTVAFDVRP HHCCCCEEEEEEECC | OGP | ||
| 101 | Phosphorylation | IWRPQGKSYLYFTQF EECCCCCEEEEEEEE | 23882029 | ||
| 102 | Phosphorylation | WRPQGKSYLYFTQFK ECCCCCEEEEEEEEE | 28152594 | ||
| 104 | Phosphorylation | PQGKSYLYFTQFKAE CCCCEEEEEEEEEEE | 28152594 | ||
| 106 | Phosphorylation | GKSYLYFTQFKAEVR CCEEEEEEEEEEEEC | 28152594 | ||
| 113 | Methylation | TQFKAEVRGAEIEYA EEEEEEECCCHHHHH | 115484099 | ||
| 119 | Phosphorylation | VRGAEIEYAMAYSKA ECCCHHHHHHHHHHH | - | ||
| 121 | Sulfoxidation | GAEIEYAMAYSKAAF CCHHHHHHHHHHHHH | 30846556 | ||
| 132 | Phosphorylation | KAAFERESDVPLKTE HHHHHCCCCCCCCCC | 26091039 | ||
| 137 | Ubiquitination | RESDVPLKTEEFEVT CCCCCCCCCCEEEEE | 21906983 | ||
| 137 | Acetylation | RESDVPLKTEEFEVT CCCCCCCCCCEEEEE | 26051181 | ||
| 138 | Phosphorylation | ESDVPLKTEEFEVTK CCCCCCCCCEEEEEE | 23312004 | ||
| 145 | Ubiquitination | TEEFEVTKTAVAHRP CCEEEEEEHHHHCCC | 27667366 | ||
| 146 | Phosphorylation | EEFEVTKTAVAHRPG CEEEEEEHHHHCCCC | 20068231 | ||
| 156 | Acetylation | AHRPGAFKAELSKLV HCCCCCHHHHHHHEE | 26822725 | ||
| 161 | 2-Hydroxyisobutyrylation | AFKAELSKLVIVAKA CHHHHHHHEEEEEEC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MYDGF_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MYDGF_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MYDGF_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| BAG6_HUMAN | BAG6 | physical | 16169070 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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