LIN7B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIN7B_HUMAN
• UniProt AC: Q9HAP6
• Protein Name: Protein lin-7 homolog B
• Gene Name: LIN7B
• Organism: Homo sapiens (Human).
• Sequence Length: 207
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Peripheral membrane protein. Cell junction, tight junction. Cell j
• Protein Description: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity)..
• Protein Sequence: MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHQSYSSLESRG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Ubiquitination	AAFTASEGHAHPRVV EHHHCCCCCCCCEEE	22.30	23503661
111	Ubiquitination	GFNIMGGKEQNSPIY CCEECCCCCCCCCEE	50.85	23503661
115	Phosphorylation	MGGKEQNSPIYISRV CCCCCCCCCEEEEEE	16.63	21815630
118	Phosphorylation	KEQNSPIYISRVIPG CCCCCCEEEEEECCC	9.02	28152594
120	Phosphorylation	QNSPIYISRVIPGGV CCCCEEEEEECCCCC	11.97	28152594
147	Phosphorylation	LLSVNGVSVEGEQHE EEEECCEEECCCHHH	18.82	20068231
173	Phosphorylation	SVKLVVRYTPRVLEE CEEEEEEECHHHHHH	14.97	22210691
174	Phosphorylation	VKLVVRYTPRVLEEM EEEEEEECHHHHHHH	8.28	22210691
190	Phosphorylation	ARFEKMRSARRRQQH HHHHHHHHHHHHHHH	23.72	-
199	Phosphorylation	RRRQQHQSYSSLESR HHHHHHHHHHHHHHC	25.51	28796482
200	Phosphorylation	RRQQHQSYSSLESRG HHHHHHHHHHHHHCC	8.84	28796482
201	Phosphorylation	RQQHQSYSSLESRG- HHHHHHHHHHHHCC-	33.42	28796482
202	Phosphorylation	QQHQSYSSLESRG-- HHHHHHHHHHHCC--	28.11	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIN7B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIN7B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIN7B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSKP_HUMAN	CASK	physical	14960569
APBA1_HUMAN	APBA1	physical	14960569
KCNJ4_HUMAN	KCNJ4	physical	11742811
DLG4_HUMAN	DLG4	physical	10341223
NMDE2_HUMAN	GRIN2B	physical	10341223

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.