KCNJ4_HUMAN - dbPTM
KCNJ4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KCNJ4_HUMAN
UniProt AC P48050
Protein Name Inward rectifier potassium channel 4
Gene Name KCNJ4
Organism Homo sapiens (Human).
Sequence Length 445
Subcellular Localization Cell membrane
Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein. Cytoplasmic vesicle membrane. TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalizati
Protein Description Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity)..
Protein Sequence MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
53PhosphorylationIFTTCVDTRWRYMLM
HHHHHHHHHHHHHHH
22817900
170PhosphorylationIDSFMIGTIMAKMAR
HHHHHHHHHHHHHCC
26657352
234PhosphorylationYMTQEGEYLPLDQRD
CCCCCCCEECCCCCC
21486282
345PhosphorylationKTYEVAGTPCCSARE
CEEEECCCCCCCHHH
24076635
356PhosphorylationSARELQESKITVLPA
CHHHHHHCCCEEECC
-
431PhosphorylationDLERMQASLPLDNIS
CHHHHHHCCCCCCCC
30631047
438PhosphorylationSLPLDNISYRRESAI
CCCCCCCCHHHHHCC
30631047
443PhosphorylationNISYRRESAI-----
CCCHHHHHCC-----
30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
53TPhosphorylationKinasePRKCAP17252
GPS
53TPhosphorylationKinasePRKCDQ05655
GPS
53TPhosphorylationKinasePKC-FAMILY-GPS
234YPhosphorylationKinaseEGFRP00533
PSP

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KCNJ4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KCNJ4_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DLG1_HUMANDLG1physical
15024025
CSKP_HUMANCASKphysical
15024025
LIN7C_HUMANLIN7Cphysical
15024025
DMD_HUMANDMDphysical
15024025
SNTA1_HUMANSNTA1physical
15024025
DLG1_HUMANDLG1physical
14960569
CSKP_HUMANCASKphysical
14960569
DLG4_HUMANDLG4physical
14960569
LIN7A_HUMANLIN7Aphysical
14960569
LIN7C_HUMANLIN7Cphysical
14960569
DLG4_HUMANDLG4physical
11997254
DLG2_HUMANDLG2physical
11997254
LIN7B_HUMANLIN7Bphysical
11742811
DLG4_HUMANDLG4physical
10627592
GBGT2_HUMANGNGT2physical
8943291

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KCNJ4_HUMAN

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Related Literatures of Post-Translational Modification

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