UniProt ID | KCNJ4_HUMAN | |
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UniProt AC | P48050 | |
Protein Name | Inward rectifier potassium channel 4 | |
Gene Name | KCNJ4 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 445 | |
Subcellular Localization |
Cell membrane Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein. Cytoplasmic vesicle membrane. TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalizati |
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Protein Description | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).. | |
Protein Sequence | MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
53 | Phosphorylation | IFTTCVDTRWRYMLM HHHHHHHHHHHHHHH | 22817900 | ||
170 | Phosphorylation | IDSFMIGTIMAKMAR HHHHHHHHHHHHHCC | 26657352 | ||
234 | Phosphorylation | YMTQEGEYLPLDQRD CCCCCCCEECCCCCC | 21486282 | ||
345 | Phosphorylation | KTYEVAGTPCCSARE CEEEECCCCCCCHHH | 24076635 | ||
356 | Phosphorylation | SARELQESKITVLPA CHHHHHHCCCEEECC | - | ||
431 | Phosphorylation | DLERMQASLPLDNIS CHHHHHHCCCCCCCC | 30631047 | ||
438 | Phosphorylation | SLPLDNISYRRESAI CCCCCCCCHHHHHCC | 30631047 | ||
443 | Phosphorylation | NISYRRESAI----- CCCHHHHHCC----- | 30631047 |
Modified Location | Modified Residue | Modification | Function | Reference | ||
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Oops, there are no descriptions of PTM sites of KCNJ4_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCNJ4_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
DLG1_HUMAN | DLG1 | physical | 15024025 | |
CSKP_HUMAN | CASK | physical | 15024025 | |
LIN7C_HUMAN | LIN7C | physical | 15024025 | |
DMD_HUMAN | DMD | physical | 15024025 | |
SNTA1_HUMAN | SNTA1 | physical | 15024025 | |
DLG1_HUMAN | DLG1 | physical | 14960569 | |
CSKP_HUMAN | CASK | physical | 14960569 | |
DLG4_HUMAN | DLG4 | physical | 14960569 | |
LIN7A_HUMAN | LIN7A | physical | 14960569 | |
LIN7C_HUMAN | LIN7C | physical | 14960569 | |
DLG4_HUMAN | DLG4 | physical | 11997254 | |
DLG2_HUMAN | DLG2 | physical | 11997254 | |
LIN7B_HUMAN | LIN7B | physical | 11742811 | |
DLG4_HUMAN | DLG4 | physical | 10627592 | |
GBGT2_HUMAN | GNGT2 | physical | 8943291 |
Kegg Disease | ||||||
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There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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