SMBT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMBT2_HUMAN
• UniProt AC: Q5VUG0
• Protein Name: Scm-like with four MBT domains protein 2
• Gene Name: SFMBT2
• Organism: Homo sapiens (Human).
• Sequence Length: 894
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor of HOXB13 gene..
• Protein Sequence: MESTLSASNMQDPSSSPLEKCLGSANGNGDLDSEEGSSLEETGFNWGEYLEETGASAAPHTSFKHVEISIQSNFQPGMKLEVANKNNPDTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVVIADLHPVGWCTQNNKVLMPPDAIKEKYTDWTEFLIRDLTGSRTAPANLLEGPLRGKGPIDLITVGSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEDTESYDQWLFYLDYRLRPVGWCQENKYRMDPPSEIYPLKMASEWKCTLEKSLIDAAKFPLPMEVFKDHADLRSHFFTVGMKLETVNMCEPFYISPASVTKVFNNHFFQVTIDDLRPEPSKLSMLCHADSLGILPVQWCLKNGVSLTPPKGYSGQDFDWADYHKQHGAQEAPPFCFRNTSFSRGFTKNMKLEAVNPRNPGELCVASVVSVKGRLMWLHLEGLQTPVPEVIVDVESMDIFPVGWCEANSYPLTAPHKTVSQKKRKIAVVQPEKQLPPTVPVKKIPHDLCLFPHLDTTGTVNGKYCCPQLFINHRCFSGPYLNKGRIAELPQSVGPGKCVLVLKEVLSMIINAAYKPGRVLRELQLVEDPHWNFQEETLKAKYRGKTYRAVVKIVRTSDQVANFCRRVCAKLECCPNLFSPVLISENCPENCSIHTKTKYTYYYGKRKKISKPPIGESNPDSGHPKPARRRKRRKSIFVQKKRRSSAVDFTAGSGEESEEEDADAMDDDTASEETGSELRDDQTDTSSAEVPSARPRRAVTLRSGSEPVRRPPPERTRRGRGAPAASSAEEGEKCPPTKPEGTEDTKQEEEERLVLESNPLEWTVTDVVRFIKLTDCAPLAKIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVKVAFYAQYAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MESTLSASNMQ ----CCCCCCCCCCC	16.07	27732954
6	Phosphorylation	--MESTLSASNMQDP --CCCCCCCCCCCCC	29.73	24719451
8	Phosphorylation	MESTLSASNMQDPSS CCCCCCCCCCCCCCC	29.47	27732954
14	Phosphorylation	ASNMQDPSSSPLEKC CCCCCCCCCCHHHHH	52.30	30108239
15	Phosphorylation	SNMQDPSSSPLEKCL CCCCCCCCCHHHHHH	41.17	30108239
16	Phosphorylation	NMQDPSSSPLEKCLG CCCCCCCCHHHHHHC	37.53	30108239
150	Ubiquitination	PPDAIKEKYTDWTEF CHHHHHHHCCCHHHH	48.74	-
251	Phosphorylation	GWCQENKYRMDPPSE CHHHCCCCCCCCHHH	23.81	22817900
257	Phosphorylation	KYRMDPPSEIYPLKM CCCCCCHHHCCCCCC	41.85	25072903
260	Phosphorylation	MDPPSEIYPLKMASE CCCHHHCCCCCCCCC	9.84	25072903
266	Phosphorylation	IYPLKMASEWKCTLE CCCCCCCCCCCCEEC	40.26	25072903
274	Acetylation	EWKCTLEKSLIDAAK CCCCEECHHHHHHHH	54.39	25953088
604	Phosphorylation	EETLKAKYRGKTYRA HHHHHHHHCCCEEEE	29.47	25884760
609	Phosphorylation	AKYRGKTYRAVVKIV HHHCCCEEEEEEEEE	10.48	25884760
672	Phosphorylation	YGKRKKISKPPIGES ECCCCCCCCCCCCCC	48.25	22210691
687	Ubiquitination	NPDSGHPKPARRRKR CCCCCCCCCHHHHHH	45.71	29967540
697	Phosphorylation	RRRKRRKSIFVQKKR HHHHHHHHEEEEECC	21.32	27251275
702	Acetylation	RKSIFVQKKRRSSAV HHHEEEEECCCCCCC	42.84	7851231
703	Acetylation	KSIFVQKKRRSSAVD HHEEEEECCCCCCCC	35.63	7851241
762	Phosphorylation	ARPRRAVTLRSGSEP CCCCCEEEECCCCCC	18.57	23532336
788	Phosphorylation	GRGAPAASSAEEGEK CCCCCCCCCCCCCCC	31.99	29396449
789	Phosphorylation	RGAPAASSAEEGEKC CCCCCCCCCCCCCCC	34.67	29396449
836	Phosphorylation	VVRFIKLTDCAPLAK HHHHHCCCCCHHHHH	24.83	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMBT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMBT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMBT2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SMBT2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.