dbPTM

CLHC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLHC1_HUMAN
UniProt AC	Q8NHS4
Protein Name	Clathrin heavy chain linker domain-containing protein 1
Gene Name	CLHC1
Organism	Homo sapiens (Human).
Sequence Length	586
Subcellular Localization
Protein Description
Protein Sequence	MSVHQIRKHAVLPPIICRSDKEFLESVQRYIITETERLGCSEEGPADEYYIIYRNVFDKVIEHITAYKSILTSIKKEYDAFIETIKKDRRTTFCLHGKLKGLAAEPTALVYYRKRTIQLEAKMRIIESNSSKIQSQIDHIKQCRAEYDTKEVKYCTFSKDPSKPIPGMTLQESMNLDALTKYMKHLEDKYAEIKQAMLIKYVPAQRKADLDEEMIVLLKRRDVAENLNKKLQFCHQRLQIISQALSSWVKSDMSSPFQDFVEQIQKTKYLQGDQGIVEELMEDDPRRAKEAEIMLHYIERFNELISLGEYEKAACYAANSPRRILRNIGTMNTFKAVGKIRGKPLPLLLFFEALFITSHAFPCPVDAALTLEGIKCGLSEKRLDLVTNWVTQERLTFSEEAGDVICDYGEQDTYNKAKCLALAQIVYSECGLHKKAILCLCKQGQTHRVMEYIQQLKDFTTDDLLQLLMSCPQVELIQCLTKELNEKQPSLSFGLAILHLFSADMKKVGIKLLQEINKGGIDAVESLMINDSFCSIEKWQEVANICSQNGFDKLSNDITSILRSQAAVTEISEEDDAVNLMEHVFW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
21	Methylation	PIICRSDKEFLESVQ CEECCCCHHHHHHHH	23644510
67	Phosphorylation	VIEHITAYKSILTSI HHHHHHHHHHHHHHH	-
150	Trimethylation	CRAEYDTKEVKYCTF HHHHCCCCCCEEEEC	-
150	Methylation	CRAEYDTKEVKYCTF HHHHCCCCCCEEEEC	23644510
200	Ubiquitination	IKQAMLIKYVPAQRK HHHHHHHHHCCCCCC	-
320	Phosphorylation	AACYAANSPRRILRN HHHHHCCCHHHHHHH	30257219
446	Phosphorylation	CLCKQGQTHRVMEYI HHCCCCCHHHHHHHH	-
560	Phosphorylation	KLSNDITSILRSQAA HHHHHHHHHHHHCCC	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CLHC1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLHC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLHC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CLHC1_HUMAN

Related Literatures of Post-Translational Modification