| UniProt ID | S35B3_HUMAN | |
|---|---|---|
| UniProt AC | Q9H1N7 | |
| Protein Name | Adenosine 3'-phospho 5'-phosphosulfate transporter 2 | |
| Gene Name | SLC35B3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 401 | |
| Subcellular Localization |
Golgi apparatus membrane Multi-pass membrane protein . |
|
| Protein Description | Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon.. | |
| Protein Sequence | MDLTQQAKDIQNITVQETNKNNSESIECSKITMDLKFNNSRKYISITVPSKTQTMSPHIKSVDDVVVLGMNLSKFNKLTQFFICVAGVFVFYLIYGYLQELIFSVEGFKSCGWYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAAICMSLGLIWFTLADSTTAPNFNLTGVVLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLTCTSGLGPAVTFCAKNPVRTYGYAFLFSLTGYFGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSKNMDKIRLPSLYDLINKSVEARKSRTLAQTV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | N-linked_Glycosylation | QQAKDIQNITVQETN HHHHHHHHCEEEECC | 32.03 | UniProtKB CARBOHYD | |
| 43 | Phosphorylation | KFNNSRKYISITVPS EECCCCCEEEEEECC | 9.97 | 28152594 | |
| 45 | Phosphorylation | NNSRKYISITVPSKT CCCCCEEEEEECCCC | 14.76 | 28152594 | |
| 47 | Phosphorylation | SRKYISITVPSKTQT CCCEEEEEECCCCCC | 21.41 | 28152594 | |
| 56 | Phosphorylation | PSKTQTMSPHIKSVD CCCCCCCCCCCCCHH | 19.40 | 25159151 | |
| 61 | Phosphorylation | TMSPHIKSVDDVVVL CCCCCCCCHHHEEEE | 30.12 | - | |
| 71 | N-linked_Glycosylation | DVVVLGMNLSKFNKL HEEEEECCHHHHHHH | 39.09 | UniProtKB CARBOHYD | |
| 254 | N-linked_Glycosylation | EKAMKLHNASNSEMV HHHHHHCCCCCCCCE | 56.34 | UniProtKB CARBOHYD | |
| 380 | Phosphorylation | MDKIRLPSLYDLINK CHHCCCCHHHHHHHH | 44.12 | 26074081 | |
| 382 | Phosphorylation | KIRLPSLYDLINKSV HCCCCHHHHHHHHHH | 17.03 | 26074081 | |
| 388 | Phosphorylation | LYDLINKSVEARKSR HHHHHHHHHHHHHHC | 22.24 | 26074081 | |
| 394 | Phosphorylation | KSVEARKSRTLAQTV HHHHHHHHCCHHCCC | 25.58 | 22210691 | |
| 396 | Phosphorylation | VEARKSRTLAQTV-- HHHHHHCCHHCCC-- | 33.27 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of S35B3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of S35B3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of S35B3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of S35B3_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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