TET3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TET3_HUMAN
• UniProt AC: O43151
• Protein Name: Methylcytosine dioxygenase TET3
• Gene Name: TET3
• Organism: Homo sapiens (Human).
• Sequence Length: 1660
• Subcellular Localization: Nucleus . Cytoplasm . Chromosome . At the zygotic stage, localizes in the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages. Binds to the promoter of target genes, close to the transcription start site.
• Protein Description: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes. [PubMed: 23217707 In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT]
• Protein Sequence: MDSGPVYHGDSRQLSASGVPVNGAREPAGPSLLGTGGPWRVDQKPDWEAAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGNNSRGPRPGPEGCSAGSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVMEGGEERPRLPGPLPPGEAGLPAPSTRPLLSSEVPQISPQEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTPQASCPLPEALSPPAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPAPSPVLQREAPTPSSEPDTHQKAQTALQQHLHHKRSLFLEQVHDTSFPAPSEPSAPGWWPPPSSPVPRLPDRPPKEKKKKLPTPAGGPVGTEKAAPGIKPSVRKPIQIKKSRPREAQPLFPPVRQIVLEGLRSPASQEVQAHPPAPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQQTCLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKSFQDLATEVAPLYKRLAPQAYQNQVTNEEIAIDCRLGLKEGRPFAGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGKIPEDEQLHVLPLYKMANTDEFGSEENQNAKVGSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKIQKEKLSTPEKIKQEALELAGITSDPGLSLKGGLSQQGLKPSLKVEPQNHFSSFKYSGNAVVESYSVLGNCRPSDPYSMNSVYSYHSYYAQPSLTSVNGFHSKYALPSFSYYGFPSSNPVFPSQFLGPGAWGHSGSSGSFEKKPDLHALHNSLSPAYGGAEFAELPSQAVPTDAHHPTPHHQQPAYPGPKEYLLPKAPLLHSVSRDPSPFAQSSNCYNRSIKQEPVDPLTQAEPVPRDAGKMGKTPLSEVSQNGGPSHLWGQYSGGPSMSPKRTNGVGGSWGVFSSGESPAIVPDKLSSFGASCLAPSHFTDGQWGLFPGEGQQAASHSGGRLRGKPWSPCKFGNSTSALAGPSLTEKPWALGAGDFNSALKGSPGFQDKLWNPMKGEEGRIPAAGASQLDRAWQSFGLPLGSSEKLFGALKSEEKLWDPFSLEEGPAEEPPSKGAVKEEKGGGGAEEEEEELWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARARQEEAARLGLGQQEAKLYGKKRKWGGTVVAEPQQKEKKGVVPTRQALAVPTDSAVTVSSYAYTKVTGPYSRWI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDSGPVYHGD -----CCCCCCCCCC	57.78	-
7	Phosphorylation	-MDSGPVYHGDSRQL -CCCCCCCCCCCCCC	11.83	-
28	Phosphorylation	VNGAREPAGPSLLGT CCCCCCCCCCCCCCC	37.46	27732954
30	Phosphorylation	GAREPAGPSLLGTGG CCCCCCCCCCCCCCC	24.74	27732954
33	Phosphorylation	EPAGPSLLGTGGPWR CCCCCCCCCCCCCCC	7.28	25849741
44	Ubiquitination	GPWRVDQKPDWEAAP CCCCCCCCCCCCCCC	40.24	-
76	Phosphorylation	SAVAEAVSSYGALST HHHHHHHHHHCHHHH	25.53	28122231
77	Phosphorylation	AVAEAVSSYGALSTR HHHHHHHHHCHHHHH	22.46	28122231
78	Phosphorylation	VAEAVSSYGALSTRL HHHHHHHHCHHHHHH	10.02	28122231
82	Phosphorylation	VSSYGALSTRLYETF HHHHCHHHHHHHHHH	15.79	28122231
83	Phosphorylation	SSYGALSTRLYETFN HHHCHHHHHHHHHHC	26.08	28122231
86	Ubiquitination	GALSTRLYETFNREM CHHHHHHHHHHCHHH	15.05	-
86	Phosphorylation	GALSTRLYETFNREM CHHHHHHHHHHCHHH	15.05	27642862
101	Phosphorylation	SREAGNNSRGPRPGP HHHCCCCCCCCCCCC	42.48	32142685
121 (in isoform 4)	Phosphorylation	-	4.20	27732954
123 (in isoform 4)	Phosphorylation	-	27.10	27732954
126 (in isoform 4)	Phosphorylation	-	9.19	25849741
156	Ubiquitination	EWLEGKIKSVVMEGG HHHHHHHEEEEECCC	40.46	-
179	Ubiquitination	PLPPGEAGLPAPSTR CCCCCCCCCCCCCCC	28.08	-
198	Ubiquitination	SEVPQISPQEGLPLS CCCCCCCCCCCCCCC	37.56	-
264	Phosphorylation	APFRSPQSYLRAPSW CCCCCCCCCCCCCCC	29.53	24719451
291	Ubiquitination	PDSSAFPPATPRTEF CCCCCCCCCCCCCCC	42.17	-
304	Phosphorylation	EFPEAWGTDTPPATP CCCCHHCCCCCCCCC	26.46	28348404
306	Phosphorylation	PEAWGTDTPPATPRS CCHHCCCCCCCCCCC	30.89	27251275
310	Phosphorylation	GTDTPPATPRSSWPM CCCCCCCCCCCCCCC	25.63	-
313	Phosphorylation	TPPATPRSSWPMPRP CCCCCCCCCCCCCCC	37.65	22210691
314	Phosphorylation	PPATPRSSWPMPRPS CCCCCCCCCCCCCCC	36.16	22210691
352	Acetylation	RPEALPTKPKVKVEA CCCCCCCCCCEEEEC	40.68	25953088
356	Sumoylation	LPTKPKVKVEAPSSS CCCCCCEEEECCCCC	40.25	-
356	Sumoylation	LPTKPKVKVEAPSSS CCCCCCEEEECCCCC	40.25	28112733
361	Phosphorylation	KVKVEAPSSSPAPAP CEEEECCCCCCCCCC	50.96	29255136
362	Phosphorylation	VKVEAPSSSPAPAPS EEEECCCCCCCCCCC	39.00	29255136
363	Phosphorylation	KVEAPSSSPAPAPSP EEECCCCCCCCCCCC	29.44	29255136
369	Phosphorylation	SSPAPAPSPVLQREA CCCCCCCCCCCCCCC	29.73	29255136
381	O-linked_Glycosylation	REAPTPSSEPDTHQK CCCCCCCCCCCHHHH	55.11	30379171
429	Phosphorylation	PGWWPPPSSPVPRLP CCCCCCCCCCCCCCC	53.71	24719451
465	Acetylation	EKAAPGIKPSVRKPI CCCCCCCCCCCCCCC	36.84	26051181
491	Sumoylation	PLFPPVRQIVLEGLR CCCCCHHHHHHHCCC	30.31	-
504	Phosphorylation	LRSPASQEVQAHPPA CCCCCCCCHHCCCCC	33.82	-
535	Ubiquitination	SLALFAPSPSRDSLL CEEEECCCCCCCCCC	31.88	29967540
545	Phosphorylation	RDSLLPPTQEMRSPS CCCCCCCCCCCCCCC	34.91	-
550	Phosphorylation	PPTQEMRSPSPMTAL CCCCCCCCCCCCCCC	28.55	28450419
552	Phosphorylation	TQEMRSPSPMTALQP CCCCCCCCCCCCCCC	28.66	28450419
555	Phosphorylation	MRSPSPMTALQPGST CCCCCCCCCCCCCCC	27.83	28450419
561	Phosphorylation	MTALQPGSTGPLPPA CCCCCCCCCCCCCCC	36.55	28450419
605	Phosphorylation	QDPENQQTCLPAPES CCCCCCCCCCCCCCC	13.27	26074081
612	Phosphorylation	TCLPAPESPFATRSP CCCCCCCCCCCCCCC	25.02	26074081
616	Phosphorylation	APESPFATRSPKQIK CCCCCCCCCCCCCEE	31.87	26074081
618	Phosphorylation	ESPFATRSPKQIKIE CCCCCCCCCCCEEEE	31.90	26074081
648	Phosphorylation	EEGGQEATPTKAENP CCCCCCCCCCCCCCC	30.64	30576142
650	Phosphorylation	GGQEATPTKAENPLT CCCCCCCCCCCCCCC	38.23	30576142
657	Phosphorylation	TKAENPLTPTLSGFL CCCCCCCCCCCCHHH	18.58	25159151
659	Phosphorylation	AENPLTPTLSGFLES CCCCCCCCCCHHHCC	28.46	25850435
661	Phosphorylation	NPLTPTLSGFLESPL CCCCCCCCHHHCCHH	29.94	28450419
666	Phosphorylation	TLSGFLESPLKYLDT CCCHHHCCHHHHCCC	37.37	29255136
673	Phosphorylation	SPLKYLDTPTKSLLD CHHHHCCCCCHHHCC	30.20	21712546
676	Ubiquitination	KYLDTPTKSLLDTPA HHCCCCCHHHCCCHH	40.07	-
677	Phosphorylation	YLDTPTKSLLDTPAK HCCCCCHHHCCCHHH	36.32	21712546
681	Phosphorylation	PTKSLLDTPAKRAQA CCHHHCCCHHHHHHC	25.72	21712546
684	Acetylation	SLLDTPAKRAQAEFP HHCCCHHHHHHCCCC	49.85	25953088
690	Phosphorylation	AKRAQAEFPTCDCVE HHHHHCCCCCCCHHH	7.32	-
718	Ubiquitination	LGSGPTVASIRELME CCCCCCHHHHHHHHH	11.17	-
747	Phosphorylation	VIYTGKEGKSSRGCP EEEECCCCCCCCCCC	38.33	-
792	Phosphorylation	VIVILILAWEGIPRS HHHHHHHHHCCCCHH	8.69	-
801	Phosphorylation	EGIPRSLGDTLYQEL CCCCHHHHHHHHHHH	27.40	-
808	Phosphorylation	GDTLYQELTDTLRKY HHHHHHHHHHHHHHH	2.87	-
811	Ubiquitination	LYQELTDTLRKYGNP HHHHHHHHHHHHCCC	24.19	29967540
812	Phosphorylation	YQELTDTLRKYGNPT HHHHHHHHHHHCCCC	5.04	-
816	Phosphorylation	TDTLRKYGNPTSRRC HHHHHHHCCCCCCCC	36.35	-
819	Ubiquitination	LRKYGNPTSRRCGLN HHHHCCCCCCCCCCC	38.57	29967540
859	Ubiquitination	SMYFNGCKYARSKTP EEEECCCCCCCCCCC	43.26	-
884	Ubiquitination	KEEEVLRKSFQDLAT HHHHHHHHHHHHHHH	52.00	-
898	Ubiquitination	TEVAPLYKRLAPQAY HHHHHHHHHHCCHHH	48.93	-
994	Ubiquitination	DEFGSEENQNAKVGS CCCCCHHHCCCCCCC	36.03	-
1019	Ubiquitination	REVRRLPEPAKSCRQ HHHHCCCHHHHHHHH	63.58	29967540
1033	Ubiquitination	QRQLEARKAAAEKKK HHHHHHHHHHHHHHH	49.80	29967540
1040	Acetylation	KAAAEKKKIQKEKLS HHHHHHHHHHHHHCC	62.53	19828831
1047	Phosphorylation	KIQKEKLSTPEKIKQ HHHHHHCCCHHHHHH	53.64	22210691
1048	Phosphorylation	IQKEKLSTPEKIKQE HHHHHCCCHHHHHHH	46.00	22210691
1053	Sumoylation	LSTPEKIKQEALELA CCCHHHHHHHHHHHC	53.83	-
1053	Sumoylation	LSTPEKIKQEALELA CCCHHHHHHHHHHHC	53.83	28112733
1069	Phosphorylation	ITSDPGLSLKGGLSQ CCCCCCCCCCCCCCC	33.67	24719451
1080	Ubiquitination	GLSQQGLKPSLKVEP CCCCCCCCCCCCCCC	39.11	-
1084	Sumoylation	QGLKPSLKVEPQNHF CCCCCCCCCCCCCCC	49.22	28112733
1183	Phosphorylation	SSGSFEKKPDLHALH CCCCCCCCCCHHHHC	36.24	-
1188	Sumoylation	EKKPDLHALHNSLSP CCCCCHHHHCCCCCC	20.15	-
1188	Ubiquitination	EKKPDLHALHNSLSP CCCCCHHHHCCCCCC	20.15	29967540
1215	Ubiquitination	QAVPTDAHHPTPHHQ CCCCCCCCCCCCCCC	30.21	-
1242	Phosphorylation	PKAPLLHSVSRDPSP CCCCCCCCCCCCCCC	23.04	24719451
1244	Phosphorylation	APLLHSVSRDPSPFA CCCCCCCCCCCCCCC	33.70	23898821
1248	Phosphorylation	HSVSRDPSPFAQSSN CCCCCCCCCCCCCCC	36.62	23898821
1262	Sumoylation	NCYNRSIKQEPVDPL CCCCCCCCCCCCCCC	50.27	-
1262	Sumoylation	NCYNRSIKQEPVDPL CCCCCCCCCCCCCCC	50.27	28112733
1285	Phosphorylation	DAGKMGKTPLSEVSQ CCCCCCCCCHHHHHH	24.59	-
1288	Phosphorylation	KMGKTPLSEVSQNGG CCCCCCHHHHHHCCC	36.84	22210691
1297	Phosphorylation	VSQNGGPSHLWGQYS HHHCCCCCCCCCCCC	34.19	-
1303	Phosphorylation	PSHLWGQYSGGPSMS CCCCCCCCCCCCCCC	12.82	28450419
1304	Phosphorylation	SHLWGQYSGGPSMSP CCCCCCCCCCCCCCC	29.41	28450419
1308	Phosphorylation	GQYSGGPSMSPKRTN CCCCCCCCCCCCCCC	34.86	22210691
1310	Phosphorylation	YSGGPSMSPKRTNGV CCCCCCCCCCCCCCC	31.44	24719451
1376	Acetylation	SGGRLRGKPWSPCKF CCCCCCCCCCCCCCC	36.56	26051181
1379	Phosphorylation	RLRGKPWSPCKFGNS CCCCCCCCCCCCCCC	29.02	23898821
1383	Phosphorylation	KPWSPCKFGNSTSAL CCCCCCCCCCCCCCC	16.64	-
1397	Sumoylation	LAGPSLTEKPWALGA CCCCCCCCCCCCCCC	63.52	-
1397	Ubiquitination	LAGPSLTEKPWALGA CCCCCCCCCCCCCCC	63.52	29967540
1409	Phosphorylation	LGAGDFNSALKGSPG CCCCCHHHHHCCCCC	34.66	-
1414	Phosphorylation	FNSALKGSPGFQDKL HHHHHCCCCCHHHCC	21.91	28348404
1426	Sumoylation	DKLWNPMKGEEGRIP HCCCCCCCCCCCCCC	65.51	28112733
1453	Phosphorylation	SFGLPLGSSEKLFGA HHCCCCCCHHHHHHH	42.90	28348404
1454	Phosphorylation	FGLPLGSSEKLFGAL HCCCCCCHHHHHHHH	36.63	28348404
1456	Ubiquitination	LPLGSSEKLFGALKS CCCCCHHHHHHHHCC	51.57	-
1505	Phosphorylation	EEEEELWSDSEHNFL HHHHHHHCCCCCCCC	43.83	28348404
1507	Phosphorylation	EEELWSDSEHNFLDE HHHHHCCCCCCCCCC	34.93	28348404
1514	Phosphorylation	SEHNFLDENIGGVAV CCCCCCCCCCCCEEE	53.55	-
1544	Phosphorylation	LHATTPLKKPNRCHP HHCCCCCCCCCCCCC	68.35	-
1597	Ubiquitination	EEAARLGLGQQEAKL HHHHHHCCCHHHHHH	7.10	29967540
1601	Ubiquitination	RLGLGQQEAKLYGKK HHCCCHHHHHHHCCC	39.62	29967540
1603	Sumoylation	GLGQQEAKLYGKKRK CCCHHHHHHHCCCCC	41.30	-
1630	Phosphorylation	EKKGVVPTRQALAVP CCCCCCCCHHHEECC	24.65	21964256
1638	Phosphorylation	RQALAVPTDSAVTVS HHHEECCCCCCCEEE	35.67	-
1640	Phosphorylation	ALAVPTDSAVTVSSY HEECCCCCCCEEEEE	27.41	-
1679	Ubiquitination	-------------------------- --------------------------		29967540
1712	Ubiquitination	----------------------------------------------------------- -----------------------------------------------------------		29967540
1738	Sumoylation	------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------		-
1738	Ubiquitination	------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------		29967540
1745	Ubiquitination	-------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------		29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TET3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TET3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TET3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
DCAF1_HUMAN	VPRBP	physical	25557551
DDB1_HUMAN	DDB1	physical	25557551

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.