dbPTM

AUXI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AUXI_HUMAN
UniProt AC	O75061
Protein Name	Putative tyrosine-protein phosphatase auxilin {ECO:0000305}
Gene Name	DNAJC6 {ECO:0000312\|HGNC:HGNC:15469}
Organism	Homo sapiens (Human).
Sequence Length	913
Subcellular Localization
Protein Description	Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity)..
Protein Sequence	MKDSENKGASSPDMEPSYGGGLFDMVKGGAGRLFSNLKDNLKDTLKDTSSRVIQSVTSYTKGDLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAIRLLYAKRPGIGLSPSHRRYLGYMCDLLADKPYRPHFKPLTIKSITVSPIPFFNKQRNGCRPYCDVLIGETKIYSTCTDFERMKEYRVQDGKIFIPLNITVQGDVVVSMYHLRSTIGSRLQAKVTNTQIFQLQFHTGFIPLDTTVLKFTKPELDACDVPEKYPQLFQVTLDVELQPHDKVIDLTPPWEHYCTKDVNPSILFSSHQEHQDTLALGGQAPIDIPPDNPRHYGQSGFFASLCWQDQKSEKSFCEEDHAALVNQESEQSDDELLTLSSPHGNANGDKPHGVKKPSKKQQEPAAPPPPEDVDLLGLEGSAMSNSFSPPAAPPTNSELLSDLFGGGGAAGPTQAGQSGVEDVFHPSGPASTQSTPRRSATSTSASPTLRVGEGATFDPFGAPSKPSGQDLLGSFLNTSSASSDPFLQPTRSPSPTVHASSTPAVNIQPDVSGGWDWHAKPGGFGMGSKSAATSPTGSSHGTPTHQSKPQTLDPFADLGTLGSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMGGGWQQGGAYNWQQPQPKPQPSMPHSSPQNRPNYNVSFSAMPGGQNERGKGSSNLEGKQKAADFEDLLSGQGFNAHKDKKGPRTIAEMRKEEMAKEMDPEKLKILEWIEGKERNIRALLSTMHTVLWAGETKWKPVGMADLVTPEQVKKVYRKAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFENQGQKPLY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1 (in isoform 4)	Acetylation	-	11.11	22814378
1 (in isoform 3)	Acetylation	-	11.11	22814378
10	Phosphorylation	DSENKGASSPDMEPS CCCCCCCCCCCCCCC	51.58	25850435
11	Phosphorylation	SENKGASSPDMEPSY CCCCCCCCCCCCCCC	25.12	25850435
17	Phosphorylation	SSPDMEPSYGGGLFD CCCCCCCCCCCCHHH	24.09	27732954
18	Phosphorylation	SPDMEPSYGGGLFDM CCCCCCCCCCCHHHH	30.42	27732954
25	Ubiquitination	YGGGLFDMVKGGAGR CCCCHHHHHCCCHHH	2.35	29967540
29	Ubiquitination	LFDMVKGGAGRLFSN HHHHHCCCHHHHHHH	21.09	33845483
38	Ubiquitination	GRLFSNLKDNLKDTL HHHHHHCHHHHHHHH	49.15	29967540
42	Ubiquitination	SNLKDNLKDTLKDTS HHCHHHHHHHHHHHH	55.72	33845483
44	Phosphorylation	LKDNLKDTLKDTSSR CHHHHHHHHHHHHHH	33.83	29083192
48	Phosphorylation	LKDTLKDTSSRVIQS HHHHHHHHHHHHHHH	27.32	29083192
49	Phosphorylation	KDTLKDTSSRVIQSV HHHHHHHHHHHHHHH	26.70	29083192
50	Phosphorylation	DTLKDTSSRVIQSVT HHHHHHHHHHHHHHH	32.43	29083192
58	Phosphorylation	RVIQSVTSYTKGDLD HHHHHHHHCCCCCCC	28.75	22210691
60	Phosphorylation	IQSVTSYTKGDLDFT HHHHHHCCCCCCCEE	28.46	22210691
71	Phosphorylation	LDFTYVTSRIIVMSF CCEEEEEEEEEEEEC	16.07	22210691
95	Ubiquitination	RNQVDDIRSFLDSRH HHCHHHHHHHHHHCC	28.49	29967540
95	Methylation	RNQVDDIRSFLDSRH HHCHHHHHHHHHHCC	28.49	-
99	Ubiquitination	DDIRSFLDSRHLDHY HHHHHHHHHCCCCEE	41.43	33845483
109	Phosphorylation	HLDHYTVYNLSPKSY CCCEEEEEECCCCHH	11.55	27732954
112	Phosphorylation	HYTVYNLSPKSYRTA EEEEEECCCCHHHHH	27.00	27134283
185	Phosphorylation	MFIFCNLYSTPGPAI HHHHHHHHCCCCHHH	9.12	-
196	Phosphorylation	GPAIRLLYAKRPGIG CHHHHHHHCCCCCCC	18.05	-
211	Phosphorylation	LSPSHRRYLGYMCDL CCHHHHHHHHHHHHH	12.39	20068231
214	Phosphorylation	SHRRYLGYMCDLLAD HHHHHHHHHHHHHCC	7.62	20068231
239	Phosphorylation	TIKSITVSPIPFFNK EEEEEEEECCCCCCC	14.41	24076635
262	Phosphorylation	CDVLIGETKIYSTCT CCEEEECCEEEEECC	19.96	25278378
265	Phosphorylation	LIGETKIYSTCTDFE EEECCEEEEECCCHH	10.24	25278378
266	Phosphorylation	IGETKIYSTCTDFER EECCEEEEECCCHHH	22.08	25278378
267	Phosphorylation	GETKIYSTCTDFERM ECCEEEEECCCHHHH	11.49	25278378
269	Phosphorylation	TKIYSTCTDFERMKE CEEEEECCCHHHHHE	43.76	29759185
375	Phosphorylation	HDKVIDLTPPWEHYC CCEEEECCCCHHHHC	24.45	24076635
453	Phosphorylation	AALVNQESEQSDDEL HHHHCCCCCCCCCCE	31.04	27080861
456	Phosphorylation	VNQESEQSDDELLTL HCCCCCCCCCCEEEC	42.87	27080861
462	Phosphorylation	QSDDELLTLSSPHGN CCCCCEEECCCCCCC	36.90	27080861
464	Phosphorylation	DDELLTLSSPHGNAN CCCEEECCCCCCCCC	36.27	27080861
465	Phosphorylation	DELLTLSSPHGNANG CCEEECCCCCCCCCC	24.83	27080861
557	Phosphorylation	PSGPASTQSTPRRSA CCCCCCCCCCCCCCC	42.69	33259812
563	Phosphorylation	TQSTPRRSATSTSAS CCCCCCCCCCCCCCC	36.86	23927012
565	Phosphorylation	STPRRSATSTSASPT CCCCCCCCCCCCCCE	33.51	23927012
566	Phosphorylation	TPRRSATSTSASPTL CCCCCCCCCCCCCEE	21.78	29255136
567	Phosphorylation	PRRSATSTSASPTLR CCCCCCCCCCCCEEE	24.77	23927012
568	Phosphorylation	RRSATSTSASPTLRV CCCCCCCCCCCEEEC	26.90	29255136
570	Phosphorylation	SATSTSASPTLRVGE CCCCCCCCCEEECCC	20.41	29255136
572	Phosphorylation	TSTSASPTLRVGEGA CCCCCCCEEECCCCC	25.38	29255136
605	Phosphorylation	SFLNTSSASSDPFLQ HHHCCCCCCCCCCCC	16.90	32142685
614	Phosphorylation	SDPFLQPTRSPSPTV CCCCCCCCCCCCCCC	30.71	26074081
616	Phosphorylation	PFLQPTRSPSPTVHA CCCCCCCCCCCCCCC	32.01	23401153
618	Phosphorylation	LQPTRSPSPTVHASS CCCCCCCCCCCCCCC	34.15	21082442
620	Phosphorylation	PTRSPSPTVHASSTP CCCCCCCCCCCCCCC	29.30	29507054
624	Phosphorylation	PSPTVHASSTPAVNI CCCCCCCCCCCCCCC	21.62	20068231
625	Phosphorylation	SPTVHASSTPAVNIQ CCCCCCCCCCCCCCC	38.91	30576142
626	Phosphorylation	PTVHASSTPAVNIQP CCCCCCCCCCCCCCC	16.87	25159151
627	Phosphorylation	TVHASSTPAVNIQPD CCCCCCCCCCCCCCC	35.84	33259812
636	Phosphorylation	VNIQPDVSGGWDWHA CCCCCCCCCCCCCCC	38.68	27080861
652	Phosphorylation	PGGFGMGSKSAATSP CCCCCCCCCCCCCCC	17.97	27080861
654	Phosphorylation	GFGMGSKSAATSPTG CCCCCCCCCCCCCCC	25.49	20363803
657	Phosphorylation	MGSKSAATSPTGSSH CCCCCCCCCCCCCCC	34.65	22496350
658	Phosphorylation	GSKSAATSPTGSSHG CCCCCCCCCCCCCCC	18.75	23401153
660	Phosphorylation	KSAATSPTGSSHGTP CCCCCCCCCCCCCCC	49.84	22496350
662	Phosphorylation	AATSPTGSSHGTPTH CCCCCCCCCCCCCCC	22.95	25159151
663	Phosphorylation	ATSPTGSSHGTPTHQ CCCCCCCCCCCCCCC	27.55	23090842
666	Phosphorylation	PTGSSHGTPTHQSKP CCCCCCCCCCCCCCC	21.42	25159151
668	Phosphorylation	GSSHGTPTHQSKPQT CCCCCCCCCCCCCCC	32.17	23090842
671	Phosphorylation	HGTPTHQSKPQTLDP CCCCCCCCCCCCCCC	38.40	23090842
675	Phosphorylation	THQSKPQTLDPFADL CCCCCCCCCCCCCCC	41.47	32142685
677	Phosphorylation	QSKPQTLDPFADLGT CCCCCCCCCCCCCCC	39.39	27251275
695	Phosphorylation	SSFASKPTTPTGLGG CCCCCCCCCCCCCCC	49.50	25159151
696	Phosphorylation	SFASKPTTPTGLGGG CCCCCCCCCCCCCCC	27.64	25159151
698	Phosphorylation	ASKPTTPTGLGGGFP CCCCCCCCCCCCCCC	42.84	27732954
701	Phosphorylation	PTTPTGLGGGFPPLS CCCCCCCCCCCCCCC	35.21	32142685
708	Phosphorylation	GGGFPPLSSPQKASP CCCCCCCCCCCCCCC	45.83	25850435
709	Phosphorylation	GGFPPLSSPQKASPQ CCCCCCCCCCCCCCC	38.75	25850435
714	Phosphorylation	LSSPQKASPQPMGGG CCCCCCCCCCCCCCC	30.97	25159151
731	Phosphorylation	QGGAYNWQQPQPKPQ CCCCCCCCCCCCCCC	41.25	32142685
740	Phosphorylation	PQPKPQPSMPHSSPQ CCCCCCCCCCCCCCC	39.43	23401153
744	Phosphorylation	PQPSMPHSSPQNRPN CCCCCCCCCCCCCCC	37.53	25159151
745	Phosphorylation	QPSMPHSSPQNRPNY CCCCCCCCCCCCCCC	27.72	25159151
766	Phosphorylation	MPGGQNERGKGSSNL CCCCCCCCCCCCCCC	60.72	32142685
771	Phosphorylation	NERGKGSSNLEGKQK CCCCCCCCCCCCHHH	54.85	32142685
801	Phosphorylation	HKDKKGPRTIAEMRK CCCCCCCCHHHHHHH	47.64	32142685
850	Methylation	VLWAGETKWKPVGMA HHHCCCCCCEECCHH	49.25	-
852	Methylation	WAGETKWKPVGMADL HCCCCCCEECCHHHC	31.23	-
867	Acetylation	VTPEQVKKVYRKAVL CCHHHHHHHHHCCEE	45.72	11790705

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
570	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AUXI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AUXI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
BAG2_HUMAN	BAG2	physical	22365833

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615528	Parkinson disease 19, juvenile-onset (PARK19)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AUXI_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-572; THR-696 ANDSER-709, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563; SER-566; THR-567AND SER-570, AND MASS SPECTROMETRY.	18669648 [Abstract]