MCUB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCUB_HUMAN
• UniProt AC: Q9NWR8
• Protein Name: Calcium uniporter regulatory subunit MCUb, mitochondrial {ECO:0000305}
• Gene Name: MCUB {ECO:0000303|PubMed:24231807, ECO:0000312|HGNC:HGNC:26076}
• Organism: Homo sapiens (Human).
• Sequence Length: 336
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways..
• Protein Sequence: MLQRGLWPWRTRLLPTPGTWRPARPWPLPPPPQVLRVKLCGNVKYYQSHHYSTVVPPDEITVIYRHGLPLVTLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIKTAAIFTADGNMISASTLMDILLMNDFKLVINKIAYDVQCPKREKPSNEHTAEMEHMKSLVHRLFTILHLEESQKKREHHLLEKIDHLKEQLQPLEQVKAGIEAHSEAKTSGLLWAGLALLSIQGGALAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLQFFHKKSKQQHFDVQQYNKLKEDLAKAKESLKQARHSLCLQMQVEELNEKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	WRTRLLPTPGTWRPA CCCCCCCCCCCCCCC		28111955
91	Phosphorylation	FVVKPMLSTVGSFLQ HHHHHHHHHHHHHHH		30576142
92	Phosphorylation	VVKPMLSTVGSFLQD HHHHHHHHHHHHHHH		29978859
95	Phosphorylation	PMLSTVGSFLQDLQN HHHHHHHHHHHHHCC		30576142
140	Malonylation	DFKLVINKIAYDVQC CHHHHHHHHHHHCCC		26320211
149	Ubiquitination	AYDVQCPKREKPSNE HHHCCCCCCCCCCCH		-
154	Phosphorylation	CPKREKPSNEHTAEM CCCCCCCCCHHHHHH		26074081
158	Phosphorylation	EKPSNEHTAEMEHMK CCCCCHHHHHHHHHH		26074081
166	Phosphorylation	AEMEHMKSLVHRLFT HHHHHHHHHHHHHHH		26074081
173	Phosphorylation	SLVHRLFTILHLEES HHHHHHHHHHHHHHH		26074081
180	Phosphorylation	TILHLEESQKKREHH HHHHHHHHHHHHHHH		26074081
191	Acetylation	REHHLLEKIDHLKEQ HHHHHHHHHHHHHHH		19608861
191	Malonylation	REHHLLEKIDHLKEQ HHHHHHHHHHHHHHH		26320211
196	Succinylation	LEKIDHLKEQLQPLE HHHHHHHHHHCHHHH		23954790
206	Ubiquitination	LQPLEQVKAGIEAHS CHHHHHHHHHHHHHH		29967540
293	Ubiquitination	QFFHKKSKQQHFDVQ HHHHHHHHCCCCCHH		29967540
304	Acetylation	FDVQQYNKLKEDLAK CCHHHHHHHHHHHHH		19608861
306	Malonylation	VQQYNKLKEDLAKAK HHHHHHHHHHHHHHH		26320211
317	Acetylation	AKAKESLKQARHSLC HHHHHHHHHHHHHHH		25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCUB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCUB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCUB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBT16_HUMAN	ZBTB16	physical	16169070

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.