GABR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GABR2_HUMAN
• UniProt AC: O75899
• Protein Name: Gamma-aminobutyric acid type B receptor subunit 2
• Gene Name: GABBR2
• Organism: Homo sapiens (Human).
• Sequence Length: 941
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GA
• Protein Description: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. [PubMed: 9872316]
• Protein Sequence: MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	PPSSPPLSIMGLMPL CCCCCCCEECCEEEC	19.12	-
90	N-linked_Glycosylation	LAIEQIRNESLLRPY HHHHHHHCCCCCCCC	44.85	22660477
104	Phosphorylation	YFLDLRLYDTECDNA CCCEEEEEECCCCCC	17.87	23403867
106	Phosphorylation	LDLRLYDTECDNAKG CEEEEEECCCCCCHH	25.59	23403867
200	Phosphorylation	YQWKRVGTLTQDVQR HCCCCCCCHHHHHHH	24.63	-
202	Phosphorylation	WKRVGTLTQDVQRFS CCCCCCHHHHHHHHH	23.66	-
209	Phosphorylation	TQDVQRFSEVRNDLT HHHHHHHHHHHHHCC	37.05	24719451
298	N-linked_Glycosylation	EQVHTEANSSRCLRK HHHHHHHHHHHHHHH	34.00	UniProtKB CARBOHYD
314	Phosphorylation	LLAAMEGYIGVDFEP HHHHHCCCCCCCCCC	4.92	29978859
323	Phosphorylation	GVDFEPLSSKQIKTI CCCCCCCCHHHEEEC	46.32	29978859
324	Phosphorylation	VDFEPLSSKQIKTIS CCCCCCCHHHEEECC	35.94	29978859
379	Phosphorylation	AMETLHASSRHQRIQ HHHHHHHHHCHHHHH	19.70	-
389	N-linked_Glycosylation	HQRIQDFNYTDHTLG HHHHHHCCCCHHHHH	47.27	22660477
404	N-linked_Glycosylation	RIILNAMNETNFFGV HHHHHHHCCCCCCCC	51.00	22660477
434	Phosphorylation	KFTQFQDSREVKVGE EEEEECCCCEEEEEE	21.40	21712546
453	N-linked_Glycosylation	ADTLEIINDTIRFQG HHHHHHHHHCHHCCC	46.14	22660477
486	Phosphorylation	LPLYSILSALTILGM HHHHHHHHHHHHHHH	21.40	22210691
583	Acetylation	WRVHAIFKNVKMKKK HHHHHHHHCCCCHHH	55.51	12649847
589	Acetylation	FKNVKMKKKIIKDQK HHCCCCHHHHCCCCE	45.78	12649859
640	Phosphorylation	DPAGRDISIRPLLEH CCCCCCCCHHHHHHH	19.48	24719451
710	Phosphorylation	CIIGAAVSFLTRDQP HHHHHHHHHHCCCCC	15.15	23312004
749	Phosphorylation	PKLITLRTNPDAATQ HHHHHCCCCCCHHHC	54.97	29052541
768	Ubiquitination	QFTQNQKKEDSKTST EECCCCCCCCCCCCC	57.92	-
772	Ubiquitination	NQKKEDSKTSTSVTS CCCCCCCCCCCCCEE	59.84	-
774	Phosphorylation	KKEDSKTSTSVTSVN CCCCCCCCCCCEECH	23.56	24076635
775	Phosphorylation	KEDSKTSTSVTSVNQ CCCCCCCCCCEECHH	32.23	24076635
776	Phosphorylation	EDSKTSTSVTSVNQA CCCCCCCCCEECHHH	24.14	24076635
779	Phosphorylation	KTSTSVTSVNQASTS CCCCCCEECHHHCHH	19.54	24076635
793	Phosphorylation	SRLEGLQSENHRLRM HHHHHHHCCCHHHHH	45.46	25404012
801	Ubiquitination	ENHRLRMKITELDKD CCHHHHHHHHHHHCC	39.79	-
813	Phosphorylation	DKDLEEVTMQLQDTP HCCHHHHHHHHCCCC	11.50	18452278
819	Phosphorylation	VTMQLQDTPEKTTYI HHHHHCCCCCHHCCC	22.01	18510355
884	Phosphorylation	DPIEDINSPEHIQRR CCCHHCCCHHHHHHH	31.81	15822905
893	Phosphorylation	EHIQRRLSLQLPILH HHHHHHHHCCCCCCC	16.56	-
913	Phosphorylation	SIGGVDASCVSPCVS CCCCCCHHHCCCCCC	15.58	-
916	Phosphorylation	GVDASCVSPCVSPTA CCCHHHCCCCCCCCC	19.53	-
920	Phosphorylation	SCVSPCVSPTASPRH HHCCCCCCCCCCCCC	24.21	23898821
922	Phosphorylation	VSPCVSPTASPRHRH CCCCCCCCCCCCCCC	32.06	23898821
924	Phosphorylation	PCVSPTASPRHRHVP CCCCCCCCCCCCCCC	25.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GABR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GABR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GABR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH3G3_HUMAN	SH3GL3	physical	16169070
GABR1_HUMAN	GABBR1	physical	9872316
ATF4_HUMAN	ATF4	physical	11087824
AKT1_HUMAN	AKT1	physical	15905570
DDIT3_HUMAN	DDIT3	physical	16081421

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D00058: Gamma-Aminobutyric acid (JAN); Gammalon (TN)
• D00241: Baclofen (JP16/USP/INN); Kemstro (TN); Lioresal (TN)
• D08861: Arbaclofen placarbil (USAN/INN)
• D09791: Arbaclofen (USAN)
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomic analysis of synaptosomes from human cerebralcortex.";
DeGiorgis J.A., Jaffe H., Moreira J.E., Carlotti C.G. Jr., Leite J.P.,Pant H.C., Dosemeci A.;
J. Proteome Res. 4:306-315(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-884, AND MASSSPECTROMETRY.
PubMed: 15822905