OPRM_HUMAN - dbPTM
OPRM_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OPRM_HUMAN
UniProt AC P35372
Protein Name Mu-type opioid receptor
Gene Name OPRM1
Organism Homo sapiens (Human).
Sequence Length 400
Subcellular Localization Cell membrane
Multi-pass membrane protein . Cell projection, axon . Perikaryon . Cell projection, dendrite . Endosome . Is rapidly internalized after agonist binding.
Isoform 12: Cytoplasm .
Protein Description Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. [PubMed: 7905839]
Protein Sequence MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9N-linked_GlycosylationDSSAAPTNASNCTDA
CCCCCCCCCCCCCHH		40.07UniProtKB CARBOHYD
12N-linked_GlycosylationAAPTNASNCTDALAY
CCCCCCCCCCHHHHH		30.23UniProtKB CARBOHYD
33N-linked_GlycosylationPSPGSWVNLSHLDGN
CCCCCCCCHHHCCCC		29.57UniProtKB CARBOHYD
40N-linked_GlycosylationNLSHLDGNLSDPCGP
CHHHCCCCCCCCCCC		35.72UniProtKB CARBOHYD
48N-linked_GlycosylationLSDPCGPNRTDLGGR
CCCCCCCCCCCCCCC		44.78UniProtKB CARBOHYD
69PhosphorylationTGSPSMITAITIMAL
CCCHHHHHHHHHHHH		11.9022210691
93PhosphorylationFGNFLVMYVIVRYTK
HHHHHHHHHHHHHHC		4.5922210691
168PhosphorylationCTMSVDRYIAVCHPV
HCCCHHHHHHHCCCC		6.70-
182PhosphorylationVKALDFRTPRNAKII
CCCCCCCCCCCCCHH		26.9611060299
263PhosphorylationLMILRLKSVRMLSGS
HHHHHHHHHHHHCCC		21.39-
268PhosphorylationLKSVRMLSGSKEKDR
HHHHHHHCCCHHHHH		31.5110908300
270PhosphorylationSVRMLSGSKEKDRNL
HHHHHCCCHHHHHHH		33.9824260401
277 (in isoform 15)Phosphorylation-3.9724260401
338PhosphorylationSCLNPVLYAFLDENF
CCCHHHHHHHHCHHH		8.78-
353S-palmitoylationKRCFREFCIPTSSNI
HHHHHHHCCCCCCCH		2.89-
356PhosphorylationFREFCIPTSSNIEQQ
HHHHCCCCCCCHHHH		25.5230576142
357PhosphorylationREFCIPTSSNIEQQN
HHHCCCCCCCHHHHH		18.9430576142
358PhosphorylationEFCIPTSSNIEQQNS
HHCCCCCCCHHHHHC		44.2830576142
365PhosphorylationSNIEQQNSTRIRQNT
CCHHHHHCHHHCCCC		18.0911278523
372PhosphorylationSTRIRQNTRDHPSTA
CHHHCCCCCCCCCCC		29.1811278523
377PhosphorylationQNTRDHPSTANTVDR
CCCCCCCCCCHHHCC		36.4111278523
377 (in isoform 2)Phosphorylation-36.4124260401
377 (in isoform 7)Phosphorylation-36.4122210691
378PhosphorylationNTRDHPSTANTVDRT
CCCCCCCCCHHHCCC		28.51-
378 (in isoform 7)Phosphorylation-28.5122210691
381 (in isoform 7)Phosphorylation-22.7122210691
385 (in isoform 7)Phosphorylation-32.3722210691
396PhosphorylationLENLEAETAPLP---
HHHHHHCCCCCC---		40.399312100
410 (in isoform 5)"N6,N6-dimethyllysine"--
410 (in isoform 5)Methylation--
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
268SPhosphorylationKinaseCAMK2AQ9UQM7
PSP
377SPhosphorylationKinaseGRK2P25098
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
377SPhosphorylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OPRM_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
OPRD_HUMANOPRD1physical
11069979
PLD2_HUMANPLD2physical
12519790
ARF1_HUMANARF1physical
12519790
OPRD_HUMANOPRD1physical
21220103
GASP1_HUMANGPRASP1physical
15086532
AUP1_HUMANAUP1physical
23840749
CSN5_HUMANCOPS5physical
23840749
CXA4_HUMANGJA4physical
23840749
DOK4_HUMANDOK4physical
23840749
DOK5_HUMANDOK5physical
23840749
KCNF1_HUMANKCNF1physical
23840749
RANB9_HUMANRANBP9physical
23840749
SIAH1_HUMANSIAH1physical
23840749
SIAH2_HUMANSIAH2physical
23840749
VAPA_HUMANVAPAphysical
23840749
WLS_HUMANWLSphysical
23840749
ZYX_HUMANZYXphysical
23840749
RANB9_HUMANRANBP9physical
19788913
ZFY26_HUMANZFYVE26physical
28514442
MMS22_HUMANMMS22Lphysical
28514442
THADA_HUMANTHADAphysical
28514442
MBOA5_HUMANLPCAT3physical
28514442
XPO6_HUMANXPO6physical
28514442
XPO4_HUMANXPO4physical
28514442
HD_HUMANHTTphysical
28514442
BRAT1_HUMANBRAT1physical
28514442
MZT2B_HUMANMZT2Bphysical
28514442
GCP2_HUMANTUBGCP2physical
28514442
ZWILC_HUMANZWILCHphysical
28514442
COG2_HUMANCOG2physical
28514442
ATM_HUMANATMphysical
28514442
URB2_HUMANURB2physical
28514442
MTFP1_HUMANMTFP1physical
28514442
COG8_HUMANCOG8physical
28514442
COX1_HUMANCOX1physical
28514442
CA112_HUMANC1orf112physical
28514442
FANCA_HUMANFANCAphysical
28514442
COG7_HUMANCOG7physical
28514442
DAAF5_HUMANDNAAF5physical
28514442
NDUB3_HUMANNDUFB3physical
28514442
COG1_HUMANCOG1physical
28514442
CHPT1_HUMANCHPT1physical
28514442
FAKD1_HUMANFASTKD1physical
28514442
INT1_HUMANINTS1physical
28514442
TTI2_HUMANTTI2physical
28514442
ECM29_HUMANKIAA0368physical
28514442
ATR_HUMANATRphysical
28514442
IPO11_HUMANIPO11physical
28514442
COG3_HUMANCOG3physical
28514442
XPO7_HUMANXPO7physical
28514442
COG4_HUMANCOG4physical
28514442
GCP3_HUMANTUBGCP3physical
28514442
GCP4_HUMANTUBGCP4physical
28514442
SNG2_HUMANSYNGR2physical
28514442
IPO13_HUMANIPO13physical
28514442
ZW10_HUMANZW10physical
28514442
ADCK1_HUMANADCK1physical
28514442
LMBD2_HUMANLMBRD2physical
28514442
AB17B_HUMANABHD17Bphysical
28514442
EXOC5_HUMANEXOC5physical
28514442
GEMI4_HUMANGEMIN4physical
28514442
S2546_HUMANSLC25A46physical
28514442
DEGS1_HUMANDEGS1physical
28514442
GCN1_HUMANGCN1L1physical
28514442
TNPO3_HUMANTNPO3physical
28514442
RINT1_HUMANRINT1physical
28514442
DYM_HUMANDYMphysical
28514442
MON2_HUMANMON2physical
28514442
NOM1_HUMANNOM1physical
28514442
STAG2_HUMANSTAG2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00195 Codeine (USP); Codeine hydrate
D00320 Fentanyl (JAN/USAN/INN); Duragesic (TN); Subsys (TN)
D00482 Propoxyphene hydrochloride (USP); Dextropropoxyphene hydrochloride; Darvon (TN)
D00498 Pentazocine (JP16/USP/INN); Fortral (TN)
D00729 Loperamide hydrochloride (JAN/USP); Imodium (TN)
D00835 Alfentanil hydrochloride (USP); Alfenta (TN)
D00836 Buprenorphine hydrochloride (JP16/USP); Buprenex (TN)
D00837 Butorphanol tartrate (JAN/USP); Stadol (TN)
D00838 Dezocine (USAN); Dalgan (TN)
D00839 Hydromorphone hydrochloride (USP); Dilaudid (TN); Exalgo (TN); Palladone (TN)
D00840 Levomethadyl acetate hydrochloride (USAN); Orlaam (TN)
D00841 Levorphanol tartrate (USP); Levorphanol tartrate dihydrate; Levo-dromoran (TN)
D00842 Morphine sulfate hydrate (JP16); Morphine sulfate (USP); Morphine sulfate pentahydrate; Astramor PH
D00843 Nalbuphine hydrochloride (USAN); Nubain (TN)
D00844 Oxymorphone hydrochloride (USP); Numorphan (TN); Opana (TN)
D00845 Sufentanil citrate (USP); Sufenta (TN)
D00847 Oxycodone hydrochloride (USP); Oxecta (TN); Oxycontin (TN); Roxicodone (TN)
D01177 Remifentanil hydrochloride (JAN/USAN); Ultiva (TN)
D01340 Naloxone hydrochloride (JP16/USP); Narcan (TN)
D01355 Tramadol hydrochloride (JAN/USAN); Ultram (TN)
D01383 Pethidine hydrochloride (JP16); Meperidine hydrochloride (USP); Demerol (TN)
D01399 Fentanyl citrate (JP16/USP); Fentora (TN); Lazanda (TN); Oralet (TN)
D01481 Dihydrocodeine phosphate (JP16); Dihydro (TN)
D01500 Trimebutine maleate (JP16); Cerekinon (TN)
D01879 Eptazocine hydrobromide (JAN); Sedapain (TN)
D02095 Naltrexone hydrochloride (USP); ReVia (TN)
D02101 Codeine phosphate hydrate (JP16); Codeine phosphate (USP); Codeine (TN)
D02102 Methadone hydrochloride (JAN/USP); Dolophine hydrochloride (TN)
D02104 Nalmefene hydrochloride; Revex (TN)
D02111 Pentazocine lactate (USP); Talwin (TN)
D02205 Ethylmorphine hydrochloride hydrate (JP16); Ethylmorphine hydrochloride dihydrate; Ethylmorphine hyd
D02227 Pentazocine hydrochloride (JAN/USP); Sosegon (TN); Talacen (TN)
D02238 Levallorphan tartrate (JP16); Lorfan (TN)
D02271 Morphine hydrochloride hydrate (JP16); Morphine hydrochloride trihydrate; Anpec (TN)
D02878 Alvimopan (USAN); Alvimopan dihydrate; Entereg (TN)
D03156 Brifentanil hydrochloride (USAN)
D03197 Butorphanol (USAN/INN)
D03405 Carfentanil citrate (USAN)
D03580 Codeine sulfate (USP); Codeine sulfate trihydrate
D03618 Cyclazocine (USAN/INN)
D03783 Oxycodone terephthalate (USP)
D03809 Difenoxin (USAN/INN)
D03825 Dihydrocodeine bitartrate (USP)
D03860 Diphenoxylate hydrochloride (USP)
D04461 Hydrocodone polistirex (USAN)
D04716 Levomethadyl acetate (USAN); Levacetylmethadol (INN)
D04764 Lofentanil oxalate (USAN)
D04924 Meptazinol hydrochloride (USAN)
D04973 Methadyl acetate (USAN); Acetylmethadol (INN)
D05048 Mirfentanil hydrochloride (USAN)
D05111 Nalmefene (USAN/INN); Selincro (TN)
D05113 Naltrexone (USAN/INN); Vivitrol (TN)
D05217 Ocfentanil hydrochloride (USAN)
D05312 Oxycodone (USAN/INN)
D05462 Oxycodone hydrochloride hydrate (JP16)
D05632 Propoxyphene napsylate (USAN); Darvon-N (TN)
D05667 Quadazocine mesylate (USAN)
D05938 Sufentanil (USAN/INN)
D06007 Tapentadol (USAN/INN)
D06147 Tilidine hydrochloride (USAN); Valoron (TN)
D06208 Trefentanil hydrochloride (USAN)
D06268 Trimeperidine (INN)
D06618 Methylnaltrexone bromide (USAN); Relistor (TN)
D07113 Loperamide oxide (INN)
D07122 Alfentanil (INN); Rapifen (TN)
D07132 Buprenorphine (JAN/INN); Temgesic (TN)
D07286 Diamorphine (BAN); Heroin; Diacetylmorphine
D07557 O-Acetyldihydrocodeine hydrochloride; Acetylcodone (TN)
D07620 Carfentanil (INN)
D07740 Codeine hydrochloride; Bisoltus (TN)
D07809 Dextropropoxyphene (INN); Propoxypene
D07810 Diacetylmorphine hydrochloride; Diamorphine hydrochloride; Heroin hydrochloride; Diamorphine (TN)
D07831 Dihydrocodeine (INN); Remedacen (TN)
D07832 Dihydrocodeine thiocyanate; Paracodin (TN)
D07861 Diphenoxylate (INN)
D07863 Diprenorphine (INN)
D07864 Diprenorphine hydrochloride; Large Animal Revivon (TN)
D07904 Eptazocine (INN)
D07929 Ethylmorphine (BAN)
D07937 Etorphine (INN)
D08045 Hydrocodone (INN); Dihydrocodeinone
D08046 Hydrocodone hydrochloride; Dihydrocodeinone hydrochloride; Dicodid (TN)
D08047 Hydromorphone (INN)
D08121 Levomethadone (INN)
D08122 Levomethadone hydrochloride; L-polamidon (TN)
D08123 Levorphanol (INN)
D08144 Loperamide (INN); Diamide (TN)
D08182 Meptazinol (INN)
D08195 Methadone (BAN)
D08233 Morphine (BAN); Morfina Dosa (TN); Substitol (TN)
D08234 Morphine tartrate; Morphine Tartrate (TN)
D08246 Nalbuphine (INN); Intapan (TN)
D08247 Nalorphine (INN); Nalorphine serb (TN)
D08248 Nalorphine hydrochloride (USP); Cloridrato de nalorfina (TN); Nalline [veterinary] (TN)
D08249 Naloxone (INN); DBL Naloxone (TN)
D08323 Oxymorphone (INN)
D08343 Pethidine (INN); Meperidine; Pethidine DBL (TN)
D08473 Remifentanil (INN); Ultiva (TN)
D08597 Tilidine (INN)
D08623 Tramadol (INN); Amanda (TN)
D08639 Trimebutine (INN); Trimebutina (TN)
D10162 Samidorphan (USAN)
D10163 Samidorphan l-malate (USAN)
D10188 Naldemedine (USAN/INN)
D10199 Tapentadol hydrochloride (JAN); Nucynta (TN)
D10349 Bevenopran (USAN/INN)
D10371 Methylsamidorphan (USAN)
D10375 Naloxegol oxalate (USAN)
D10403 Eluxadoline (USAN)
D10436 Cebranopadol (USAN/INN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OPRM_HUMAN

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