| UniProt ID | DOK5_HUMAN | |
|---|---|---|
| UniProt AC | Q9P104 | |
| Protein Name | Docking protein 5 | |
| Gene Name | DOK5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 306 | |
| Subcellular Localization | ||
| Protein Description | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.. | |
| Protein Sequence | MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 37 | Acetylation | VFKKASSKGPKRLEK HHHHHHCCCCCHHHH | 76.40 | 20167786 | |
| 256 | Phosphorylation | KMSERAASLSTMVPL HHHHHHHHHHHCCCC | 23.13 | 28348404 | |
| 277 | Phosphorylation | QHITRQHSTGQLYRL HHHHHHCCCCCEEEE | 26.37 | 24719451 | |
| 278 | Phosphorylation | HITRQHSTGQLYRLQ HHHHHCCCCCEEEEE | 27.16 | 28348404 | |
| 302 | Phosphorylation | RTETFPAYRSEH--- ECCCCCCCCCCC--- | 18.21 | 30257219 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DOK5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DOK5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DOK5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RET_HUMAN | RET | physical | 15286081 | |
| RET_HUMAN | RET | physical | 11470823 | |
| DOK3_HUMAN | DOK3 | physical | 25814554 | |
| SCOC_HUMAN | SCOC | physical | 25814554 | |
| OLIG1_HUMAN | OLIG1 | physical | 25814554 | |
| WIZ_HUMAN | WIZ | physical | 25814554 | |
| AHDC1_HUMAN | AHDC1 | physical | 25814554 | |
| ATF3_HUMAN | ATF3 | physical | 25814554 | |
| CDCA4_HUMAN | CDCA4 | physical | 25814554 | |
| FANCG_HUMAN | FANCG | physical | 25814554 | |
| RAI2_HUMAN | RAI2 | physical | 25814554 | |
| TSC1_HUMAN | TSC1 | physical | 25814554 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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