VEGFB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VEGFB_HUMAN
• UniProt AC: P49765
• Protein Name: Vascular endothelial growth factor B
• Gene Name: VEGFB
• Organism: Homo sapiens (Human).
• Sequence Length: 207
• Subcellular Localization: Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
• Protein Description: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis..
• Protein Sequence: MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPLLRRLL ------CCHHHHHHH	25.02	24719451
71	Phosphorylation	VAKQLVPSCVTVQRC HHHHHHCCCEEEEEC	17.46	30243723
74	Phosphorylation	QLVPSCVTVQRCGGC HHHCCCEEEEECCCC	18.43	30243723
106	Phosphorylation	MQILMIRYPSSQLGE EEEEEEECCHHHHCC	9.13	29978859
108	Phosphorylation	ILMIRYPSSQLGEMS EEEEECCHHHHCCCC	23.06	29978859
109	Phosphorylation	LMIRYPSSQLGEMSL EEEECCHHHHCCCCH	25.56	29978859
115	Phosphorylation	SSQLGEMSLEEHSQC HHHHCCCCHHHHHCC	28.46	29978859
120	Phosphorylation	EMSLEEHSQCECRPK CCCHHHHHCCCCCCC	39.54	29978859
183	O-linked_Glycosylation	AHAAPSTTSALTPGP CCCCCCCCCCCCCCH	19.15	OGP
187	O-linked_Glycosylation	PSTTSALTPGPAAAA CCCCCCCCCCHHHHH	26.39	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VEGFB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VEGFB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VEGFB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLH12_HUMAN	KLHL12	physical	25416956
FAT1_HUMAN	FAT1	physical	26186194
TIRR_HUMAN	NUDT16L1	physical	26186194
TRI68_HUMAN	TRIM68	physical	26186194
VEGFA_HUMAN	VEGFA	physical	26186194
HUTH_HUMAN	HAL	physical	26186194
CO6A2_HUMAN	COL6A2	physical	26186194
LOXE3_HUMAN	ALOXE3	physical	26186194
LRFN3_HUMAN	LRFN3	physical	26186194
VEGFA_HUMAN	VEGFA	physical	25241761
TRI68_HUMAN	TRIM68	physical	28514442
VEGFA_HUMAN	VEGFA	physical	28514442
HUTH_HUMAN	HAL	physical	28514442
TIRR_HUMAN	NUDT16L1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.