ARRD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARRD3_HUMAN
• UniProt AC: Q96B67
• Protein Name: Arrestin domain-containing protein 3
• Gene Name: ARRDC3
• Organism: Homo sapiens (Human).
• Sequence Length: 414
• Subcellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome . Endosome . Early endosome . Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis (PubMed:16269462, PubMed:23208550, PubMed:
• Protein Description: Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. [PubMed: 20559325]
• Protein Sequence: MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	TGEIRVKSLKIHARG EEEEEEEEEEEEECC	31.85	24719451
207	Phosphorylation	KGYTPGESIQIFAEI CCCCCCCCEEEEEEE	26.21	-
218	Phosphorylation	FAEIENCSSRMVVPK EEEEECCCCCCCCCH	32.34	22210691
219	Phosphorylation	AEIENCSSRMVVPKA EEEECCCCCCCCCHH	26.96	22210691
229	Phosphorylation	VVPKAAIYQTQAFYA CCCHHHHHHHHHHHH	10.77	28258704
259	Ubiquitination	GESLSSGKTETWNGK CCCCCCCCCEEECCE	45.17	32142685
311	Phosphorylation	NLPLVIGTIPLHPFG CCCEEEEEEECCCCC	14.32	26074081
319	Phosphorylation	IPLHPFGSRTSSVSS EECCCCCCCCCCCHH	32.53	26074081
321	Phosphorylation	LHPFGSRTSSVSSQC CCCCCCCCCCCHHCC	27.35	26074081
322	Phosphorylation	HPFGSRTSSVSSQCS CCCCCCCCCCHHCCC	27.86	26074081
323	Phosphorylation	PFGSRTSSVSSQCSM CCCCCCCCCHHCCCC	25.96	26074081
325	Phosphorylation	GSRTSSVSSQCSMNM CCCCCCCHHCCCCCC	19.35	26074081
326	Phosphorylation	SRTSSVSSQCSMNMN CCCCCCHHCCCCCCC	32.81	26074081
329	Phosphorylation	SSVSSQCSMNMNWLS CCCHHCCCCCCCEEH	12.93	26074081
382	Phosphorylation	LQGPLFAYIQEFRFL HCCCHHHHHEEECCC	8.87	26356563
394	Phosphorylation	RFLPPPLYSEIDPNP CCCCCCCCCCCCCCC	15.27	27259358
395	Phosphorylation	FLPPPLYSEIDPNPD CCCCCCCCCCCCCCC	35.44	24961811
404	Phosphorylation	IDPNPDQSADDRPSC CCCCCCCCCCCCCCC	40.83	25278378
410	Phosphorylation	QSADDRPSCPSR--- CCCCCCCCCCCC---	39.28	23312004
413	Phosphorylation	DDRPSCPSR------ CCCCCCCCC------	55.75	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARRD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARRD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARRD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_HUMAN	NEDD4	physical	20559325
ITB4_HUMAN	ITGB4	physical	20603614
WWP1_HUMAN	WWP1	physical	21191027
WWP2_HUMAN	WWP2	physical	23236378
ITCH_HUMAN	ITCH	physical	23236378
NED4L_HUMAN	NEDD4L	physical	23236378
MAGI2_HUMAN	MAGI2	physical	23236378
ARRB1_HUMAN	ARRB1	physical	23236378
ARRB2_HUMAN	ARRB2	physical	23236378
OTUB2_HUMAN	OTUB2	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
ADRB2_HUMAN	ADRB2	physical	21982743
ADRB3_HUMAN	ADRB3	physical	21982743
ADRB2_HUMAN	ADRB2	physical	23236378
HGS_HUMAN	HGS	physical	23208550
WWP2_HUMAN	WWP2	physical	26490116
HECW2_HUMAN	HECW2	physical	28514442
WWOX_HUMAN	WWOX	physical	28514442
NED4L_HUMAN	NEDD4L	physical	28514442
FGFR3_HUMAN	FGFR3	physical	28514442
STXB4_HUMAN	STXBP4	physical	28514442
NEDD4_HUMAN	NEDD4	physical	28514442
CD320_HUMAN	CD320	physical	28514442
WWP1_HUMAN	WWP1	physical	28514442
ITCH_HUMAN	ITCH	physical	28514442
RN149_HUMAN	RNF149	physical	28514442
CUED1_HUMAN	CUEDC1	physical	28514442
TR10B_HUMAN	TNFRSF10B	physical	28514442
ZN593_HUMAN	ZNF593	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
KC1G3_HUMAN	CSNK1G3	physical	28514442
PTPRS_HUMAN	PTPRS	physical	28514442
IKIP_HUMAN	IKBIP	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.