ADRB3_HUMAN - dbPTM
ADRB3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADRB3_HUMAN
UniProt AC P13945
Protein Name Beta-3 adrenergic receptor
Gene Name ADRB3
Organism Homo sapiens (Human).
Sequence Length 408
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis..
Protein Sequence MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
8N-linked_GlycosylationMAPWPHENSSLAPWP
CCCCCCCCCCCCCCC
33.59UniProtKB CARBOHYD
26N-linked_GlycosylationTLAPNTANTSGLPGV
CCCCCCCCCCCCCCC
32.51UniProtKB CARBOHYD
153S-palmitoylationGALVTKRCARTAVVL
CHHHHHHHHCHHHHH
2.9930541923
292S-palmitoylationLREHRALCTLGLIMG
HHHHHHHHHHHHHHH
2.6330541923
361S-palmitoylationSAFRRLLCRCGRRLP
HHHHHHHHHCCCCCC
3.9130541923
363S-palmitoylationFRRLLCRCGRRLPPE
HHHHHHHCCCCCCCC
4.9230541923

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADRB3_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADRB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADRB3_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SRC_HUMANSRCphysical
11013230

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADRB3_HUMAN

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Related Literatures of Post-Translational Modification

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