GASR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GASR_HUMAN
• UniProt AC: P32239
• Protein Name: Gastrin/cholecystokinin type B receptor
• Gene Name: CCKBR
• Organism: Homo sapiens (Human).
• Sequence Length: 447
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism..
• Protein Sequence: MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	N-linked_Glycosylation	-MELLKLNRSVQGTG -CCCCCCCCCCCCCC	32.37	UniProtKB CARBOHYD
30	N-linked_Glycosylation	RPGAPLLNSSSVGNL CCCCCCCCCCCCCCC	47.75	UniProtKB CARBOHYD
36	N-linked_Glycosylation	LNSSSVGNLSCEPPR CCCCCCCCCCCCCCC	26.99	UniProtKB CARBOHYD
59	Phosphorylation	LELAIRITLYAVIFL HHHHHHHHHHHHHHH	12.13	22210691
61	Phosphorylation	LAIRITLYAVIFLMS HHHHHHHHHHHHHHH	7.09	-
68	Phosphorylation	YAVIFLMSVGGNMLI HHHHHHHHCCCCEEE	21.54	22210691
82	Phosphorylation	IIVVLGLSRRLRTVT EEHHHCHHHHHHHHH	17.35	-
294	Phosphorylation	GEDSDGCYVQLPRSR CCCCCCCEEECCCCC	9.21	-
408	S-palmitoylation	CLETCARCCPRPPRA HHHHHHHHCCCCCCC	1.67	-
427	Phosphorylation	LPDEDPPTPSIASLS CCCCCCCCCCHHHHH	34.75	22210691
432	Phosphorylation	PPTPSIASLSRLSYT CCCCCHHHHHHCEEE	25.80	22210691
434	Phosphorylation	TPSIASLSRLSYTTI CCCHHHHHHCEEEEH	28.78	27174698
437	Phosphorylation	IASLSRLSYTTISTL HHHHHHCEEEEHHCC	21.23	21156802
438	Phosphorylation	ASLSRLSYTTISTLG HHHHHCEEEEHHCCC	16.70	22817900
439	Phosphorylation	SLSRLSYTTISTLGP HHHHCEEEEHHCCCC	17.80	21156802
440	Phosphorylation	LSRLSYTTISTLGPG HHHCEEEEHHCCCCC	12.51	21156802
442	Phosphorylation	RLSYTTISTLGPG-- HCEEEEHHCCCCC--	18.58	21156802
443	Phosphorylation	LSYTTISTLGPG--- CEEEEHHCCCCC---	31.70	21156802

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GASR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GASR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GASR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NTRI_HUMAN	NTM	physical	25416956
GMCL1_HUMAN	GMCL1	physical	28514442
KIRR1_HUMAN	KIRREL	physical	28514442
PXK_HUMAN	PXK	physical	28514442
AAKB1_HUMAN	PRKAB1	physical	28514442
AAPK1_HUMAN	PRKAA1	physical	28514442
AAKG1_HUMAN	PRKAG1	physical	28514442
THADA_HUMAN	THADA	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D01818: Proglumide (JP16/USAN/INN); Nulsa (TN)
• D01858: Panazepide (JAN); Pranazepide; FK 480; FR 120480
• D02693: Devazepide (USAN/INN); L 364718
• D02710: Tarazepide (INN)
• DrugBank
• There are no disease associations of PTM sites.