PA2GD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PA2GD_HUMAN
• UniProt AC: Q9UNK4
• Protein Name: Group IID secretory phospholipase A2
• Gene Name: PLA2G2D
• Organism: Homo sapiens (Human).
• Sequence Length: 145
• Subcellular Localization: Secreted .
• Protein Description: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined..
• Protein Sequence: MELALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDWCCQTHDCCYDHLKTQGCSIYKDYYRYNFSQGNIHCSDKGSWCEQQLCACDKEVAFCLKRNLDTYQKRLRFYWRPHCRGQTPGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	GKMPILSYWPYGCHC CCCCCHHCCCCCCCC	13.63	-
82	Phosphorylation	KTQGCSIYKDYYRYN HHCCCEEHHHEEEEE	4.98	-
85	Phosphorylation	GCSIYKDYYRYNFSQ CCEEHHHEEEEECCC	5.91	-
86	Phosphorylation	CSIYKDYYRYNFSQG CEEHHHEEEEECCCC	19.43	-
89	N-linked_Glycosylation	YKDYYRYNFSQGNIH HHHEEEEECCCCCEE	22.54	UniProtKB CARBOHYD
126	Phosphorylation	LKRNLDTYQKRLRFY HHCCHHHHHHHHHHH	16.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PA2GD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PA2GD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PA2GD_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PA2GD_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.