RGS8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGS8_HUMAN
• UniProt AC: P57771
• Protein Name: Regulator of G-protein signaling 8
• Gene Name: RGS8
• Organism: Homo sapiens (Human).
• Sequence Length: 180
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Perikaryon . Cell projection, dendrite . Nucleus . Detected in Purkinje cell soma and dendrites. Associated with Purkinje cel
• Protein Description: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. [PubMed: 18434541 Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity]
• Protein Sequence: MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10 (in isoform 2)	Phosphorylation	-	46.65	-
26	Phosphorylation	CLSHKSDSCSDFTAI HHCCCCCCCCCCHHH	23.70	-
46	Phosphorylation	NRALKRLSTEEATRW CHHHHHCCHHHHHHH	37.49	29083192
47	Phosphorylation	RALKRLSTEEATRWA HHHHHCCHHHHHHHH	42.30	29083192
51	Phosphorylation	RLSTEEATRWADSFD HCCHHHHHHHHHHHH	29.98	29083192
56	Phosphorylation	EATRWADSFDVLLSH HHHHHHHHHHHHHHC	18.66	29083192
98	O-linked_Glycosylation	EFKKTRSTAKLVSKA HHHHHHHHHHHHHHH	25.23	30379171
139	Phosphorylation	RKNLQEPSLTCFDQA HHHCCCCCCEEHHHH	35.24	30619164
141	Phosphorylation	NLQEPSLTCFDQAQG HCCCCCCEEHHHHCC	18.57	30619164
158	Phosphorylation	HSLMEKDSYPRFLRS HHHHHHCCHHHHHHH	48.37	26074081
159	Phosphorylation	SLMEKDSYPRFLRSK HHHHHCCHHHHHHHH	14.46	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGS8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGS8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGS8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBR2_HUMAN	UBR2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.