AGRG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGRG1_HUMAN
• UniProt AC: Q9Y653
• Protein Name: Adhesion G-protein coupled receptor G1
• Gene Name: ADGRG1 {ECO:0000312|HGNC:HGNC:4512}
• Organism: Homo sapiens (Human).
• Sequence Length: 693
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .; ADGRG1 N-terminal fragment: Secreted .; ADGRG1 C-terminal fragment: Membrane raft . Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of
• Protein Description: Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. [PubMed: 22238662 Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA]
• Protein Sequence: MTPQSLLQTTLFLLSLLFLVQGAHGRGHREDFRFCSQRNQTHRSSLHYKPTPDLRISIENSEEALTVHAPFPAAHPASRSFPDPRGLYHFCLYWNRHAGRLHLLYGKRDFLLSDKASSLLCFQHQEESLAQGPPLLATSVTSWWSPQNISLPSAASFTFSFHSPPHTAAHNASVDMCELKRDLQLLSQFLKHPQKASRRPSAAPASQQLQSLESKLTSVRFMGDMVSFEEDRINATVWKLQPTAGLQDLHIHSRQEEEQSEIMEYSVLLPRTLFQRTKGRSGEAEKRLLLVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVANLTEPVVLTFQHQLQPKNVTLQCVFWVEDPTLSSPGHWSSAGCETVRRETQTSCFCNHLTYFAVLMVSSVEVDAVHKHYLSLLSYVGCVVSALACLVTIAAYLCSRVPLPCRRKPRDYTIKVHMNLLLAVFLLDTSFLLSEPVALTGSEAGCRASAIFLHFSLLTCLSWMGLEGYNLYRLVVEVFGTYVPGYLLKLSAMGWGFPIFLVTLVALVDVDNYGPIILAVHRTPEGVIYPSMCWIRDSLVSYITNLGLFSLVFLFNMAMLATMVVQILRLRPHTQKWSHVLTLLGLSLVLGLPWALIFFSFASGTFQLVVLYLFSIITSFQGFLIFIWYWSMRLQARGGPSPLKSNSDSARLPISSGSTSSSRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5 (in isoform 3)	Phosphorylation	-		26503514
15 (in isoform 3)	Phosphorylation	-		22210691
23 (in isoform 3)	Phosphorylation	-		26503514
25 (in isoform 3)	Phosphorylation	-		26503514
26 (in isoform 3)	Phosphorylation	-		26503514
39	N-linked_Glycosylation	FRFCSQRNQTHRSSL CHHHCCCCCCCCCCC		UniProtKB CARBOHYD
44	Phosphorylation	QRNQTHRSSLHYKPT CCCCCCCCCCCCCCC		29449344
45	Phosphorylation	RNQTHRSSLHYKPTP CCCCCCCCCCCCCCC		29449344
48	Phosphorylation	THRSSLHYKPTPDLR CCCCCCCCCCCCCEE		29449344
51	O-linked_Glycosylation	SSLHYKPTPDLRISI CCCCCCCCCCEEEEE		55826007
107	2-Hydroxyisobutyrylation	RLHLLYGKRDFLLSD EEEEEECCCCCCCCC		-
148	N-linked_Glycosylation	TSWWSPQNISLPSAA CCCCCCCCCCCCCCE		UniProtKB CARBOHYD
171	N-linked_Glycosylation	PPHTAAHNASVDMCE CCCHHHCCCCCCHHH		UniProtKB CARBOHYD
187	Phosphorylation	KRDLQLLSQFLKHPQ HHHHHHHHHHHHCHH		25106551
197	Phosphorylation	LKHPQKASRRPSAAP HHCHHHHCCCCCCCC		23882029
201	Phosphorylation	QKASRRPSAAPASQQ HHHCCCCCCCCHHHH		26657352
206	Phosphorylation	RPSAAPASQQLQSLE CCCCCCHHHHHHHHH		23312004
234	N-linked_Glycosylation	SFEEDRINATVWKLQ CCCHHHHEEEEEECC		UniProtKB CARBOHYD
260	Phosphorylation	SRQEEEQSEIMEYSV CCCHHHHHHHHHHHH		25690035
266	Phosphorylation	QSEIMEYSVLLPRTL HHHHHHHHHHHHHHH		25690035
286 (in isoform 2)	Ubiquitination	-		-
302 (in isoform 2)	Ubiquitination	-		-
303	N-linked_Glycosylation	QALFQDKNSSQVLGE HHHHCCCCHHHHCCC		UniProtKB CARBOHYD
324	N-linked_Glycosylation	VQNTKVANLTEPVVL EECCCCCCCCCCEEE		UniProtKB CARBOHYD
341	N-linked_Glycosylation	QHQLQPKNVTLQCVF EECCCCCCEEEEEEE		UniProtKB CARBOHYD
343	Phosphorylation	QLQPKNVTLQCVFWV CCCCCCEEEEEEEEE		-
667 (in isoform 2)	Ubiquitination	-		-
670	Phosphorylation	LQARGGPSPLKSNSD HHHCCCCCCCCCCCC		29396449
673	Ubiquitination	RGGPSPLKSNSDSAR CCCCCCCCCCCCCCC		-
674	Phosphorylation	GGPSPLKSNSDSARL CCCCCCCCCCCCCCC		23663014
676	Phosphorylation	PSPLKSNSDSARLPI CCCCCCCCCCCCCCC		23663014
678	Phosphorylation	PLKSNSDSARLPISS CCCCCCCCCCCCCCC		23663014
684	Phosphorylation	DSARLPISSGSTSSS CCCCCCCCCCCCCCC		22167270
685	Phosphorylation	SARLPISSGSTSSSR CCCCCCCCCCCCCCC		29255136
687	Phosphorylation	RLPISSGSTSSSRI- CCCCCCCCCCCCCC-		29255136
688	Phosphorylation	LPISSGSTSSSRI-- CCCCCCCCCCCCC--		29255136
689	Phosphorylation	PISSGSTSSSRI--- CCCCCCCCCCCC---		22167270
690	Phosphorylation	ISSGSTSSSRI---- CCCCCCCCCCC----		22167270
691	Phosphorylation	SSGSTSSSRI----- CCCCCCCCCC-----		22167270

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGRG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGRG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGRG1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AGRG1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.