STAT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAT4_HUMAN
• UniProt AC: Q14765
• Protein Name: Signal transducer and activator of transcription 4
• Gene Name: STAT4
• Organism: Homo sapiens (Human).
• Sequence Length: 748
• Subcellular Localization: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
• Protein Description: Carries out a dual signal transduction and activation of transcription. Involved in IL12 signaling..
• Protein Sequence: MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPHSPSDLLPMSPSVYAVLRENLSPTTIETAMKSPYSAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
130	Phosphorylation	VQGPLEKSLQSSSVS CCCCHHHHHCCCCHH	23.43	21712546
137	Phosphorylation	SLQSSSVSERQRNVE HHCCCCHHHHHHHHH	29.07	21712546
151	Ubiquitination	EHKVAAIKNSVQMTE HHHHHHHHHHHHCCH	38.14	29967540
204	Phosphorylation	TLQEMLNSLDFKRKE HHHHHHHCCCCCHHH	25.92	24719451
283	Phosphorylation	LEKLEEQSTKMTYEG HHHHHHHHCCCCCCC	33.02	23403867
284	Phosphorylation	EKLEEQSTKMTYEGD HHHHHHHCCCCCCCC	25.24	23403867
287	Phosphorylation	EEQSTKMTYEGDPIP HHHHCCCCCCCCCCC	21.70	20393185
288	Phosphorylation	EQSTKMTYEGDPIPM HHHCCCCCCCCCCCC	17.89	-
298	Phosphorylation	DPIPMQRTHMLERVT CCCCCCHHHHHHHHH	8.51	-
355	Phosphorylation	IKLPELNYQVKVKAS HCCCCCCEEEEEEEE	27.58	22817900
362	Phosphorylation	YQVKVKASIDKNVST EEEEEEEECCCCCCH	26.13	-
369	Phosphorylation	SIDKNVSTLSNRRFV ECCCCCCHHCCCEEE	29.89	-
371	Phosphorylation	DKNVSTLSNRRFVLC CCCCCHHCCCEEEEE	28.51	-
386	Phosphorylation	GTNVKAMSIEESSNG CCCEEEEEEEECCCC	31.54	-
394	Phosphorylation	IEESSNGSLSVEFRH EEECCCCCEEEEEEE	23.01	-
396	Phosphorylation	ESSNGSLSVEFRHLQ ECCCCCEEEEEEECC	22.69	-
405	Acetylation	EFRHLQPKEMKSSAG EEEECCCHHCCCCCC	58.44	25953088
526	Phosphorylation	AEKLTVQSSYSDGHL HHHHCCCCCCCCCCC	27.23	29978859
527	Phosphorylation	EKLTVQSSYSDGHLT HHHCCCCCCCCCCCH	16.15	29978859
528	Phosphorylation	KLTVQSSYSDGHLTW HHCCCCCCCCCCCHH	18.94	29978859
529	Phosphorylation	LTVQSSYSDGHLTWA HCCCCCCCCCCCHHH	38.78	29978859
562	Ubiquitination	EAILDLIKKHILPLW HHHHHHHHHCCHHHH	45.67	-
645	Phosphorylation	FADILRDYKVIMAEN HHHHHHHCEEEEECC	10.75	-
660	Phosphorylation	IPENPLKYLYPDIPK CCCCCHHHHCCCCCC	21.10	26503514
662	Phosphorylation	ENPLKYLYPDIPKDK CCCHHHHCCCCCCCC	8.86	26503514
693	Phosphorylation	TERGDKGYVPSVFIP CCCCCCCCCCEEEEE	18.22	10961885
696	Phosphorylation	GDKGYVPSVFIPIST CCCCCCCEEEEEEHH	21.44	28442448
702	Phosphorylation	PSVFIPISTIRSDST CEEEEEEHHCCCCCC	16.66	22617229
706	Phosphorylation	IPISTIRSDSTEPHS EEEHHCCCCCCCCCC	31.87	29978859
708	Phosphorylation	ISTIRSDSTEPHSPS EHHCCCCCCCCCCHH	35.60	27080861
709	Phosphorylation	STIRSDSTEPHSPSD HHCCCCCCCCCCHHH	59.53	27080861
713	Phosphorylation	SDSTEPHSPSDLLPM CCCCCCCCHHHHCCC	36.49	26657352
715	Phosphorylation	STEPHSPSDLLPMSP CCCCCCHHHHCCCCH	43.86	29978859
721	Phosphorylation	PSDLLPMSPSVYAVL HHHHCCCCHHHHHHH	16.45	10961885
723	Phosphorylation	DLLPMSPSVYAVLRE HHCCCCHHHHHHHHH	22.06	29978859
725	Phosphorylation	LPMSPSVYAVLRENL CCCCHHHHHHHHHCC	8.71	27080861
733	Phosphorylation	AVLRENLSPTTIETA HHHHHCCCCCCHHHH	31.61	23401153
735	Phosphorylation	LRENLSPTTIETAMK HHHCCCCCCHHHHHC	36.71	27251275
736	Phosphorylation	RENLSPTTIETAMKS HHCCCCCCHHHHHCC	21.87	27251275
739	Phosphorylation	LSPTTIETAMKSPYS CCCCCHHHHHCCCCC	28.35	29978859
743	Phosphorylation	TIETAMKSPYSAE-- CHHHHHCCCCCCC--	18.91	-
745	Phosphorylation	ETAMKSPYSAE---- HHHHCCCCCCC----	27.83	-
746	Phosphorylation	TAMKSPYSAE----- HHHCCCCCCC-----	29.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
693	Y	Phosphorylation	Kinase	JAK-FAMILY	-	GPS
693	Y	Phosphorylation	Kinase	JAK	-	Uniprot
693	Y	Phosphorylation	Kinase	JAK_GROUP	-	PhosphoELM
721	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAT4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
I12R2_HUMAN	IL12RB2	physical	10415122

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 612253: Systemic lupus erythematosus 11 (SLEB11)
• 180300: Rheumatoid arthritis (RA)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.