I12R2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: I12R2_HUMAN
• UniProt AC: Q99665
• Protein Name: Interleukin-12 receptor subunit beta-2
• Gene Name: IL12RB2
• Organism: Homo sapiens (Human).
• Sequence Length: 862
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production..
• Protein Sequence: MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYKVLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCDSLML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	N-linked_Glycosylation	ILLGSTVNITCSLKP EEECCEEEEEEECCC	24.76	UniProtKB CARBOHYD
129	N-linked_Glycosylation	VAPEQPQNLSCIQKG ECCCCCCCEECEECC	40.37	UniProtKB CARBOHYD
166	N-linked_Glycosylation	LQLSGPKNLTWQKQC EEECCCCCCCHHHHC	45.92	UniProtKB CARBOHYD
195	N-linked_Glycosylation	TPESPESNFTAKVTA CCCCCCCCCEEEEEE	36.30	UniProtKB CARBOHYD
271	N-linked_Glycosylation	SRLWNMVNVTKAKGR CCHHHHHEEEECCCC	25.60	UniProtKB CARBOHYD
347	N-linked_Glycosylation	QISLFWKNLSVSEAR HHHHHEECCCHHHHH	28.30	UniProtKB CARBOHYD
376	N-linked_Glycosylation	GGKAMTQNITGHTSW CCCCEEEECCCCCCE	25.32	UniProtKB CARBOHYD
390	Phosphorylation	WTTVIPRTGNWAVAV EEEEECCCCCEEEEE	29.52	-
406	Phosphorylation	AANSKGSSLPTRINI EECCCCCCCCCCCCH	47.22	24719451
480	N-linked_Glycosylation	WLRSRPYNVSALISE HHHCCCCCHHHHHCC	24.77	UniProtKB CARBOHYD
565	Phosphorylation	IYWKERDSNSQPQLC EEECCCCCCCCCCEE	44.60	22210691
607	Phosphorylation	ALTAAGESSHGNERE HHHHCCCCCCCCCCE	27.07	22210691
630	Phosphorylation	WMAFVAPSICIAIIM HHHHHHHHHHHHHHH	21.98	-
749	Phosphorylation	DMMHSASSPPPPRAL HHCCCCCCCCCCHHH	40.94	20058876
767	Phosphorylation	SRQLVDLYKVLESRG HHHHHHHHHHHHHCC	8.45	28111955
768	Ubiquitination	RQLVDLYKVLESRGS HHHHHHHHHHHHCCC	47.87	-
772	Phosphorylation	DLYKVLESRGSDPKP HHHHHHHHCCCCCCC	37.47	28111955
800	Phosphorylation	DLPTHDGYLPSNIDD CCCCCCCCCCCCCCC	22.84	9890938
859	Phosphorylation	QLKMRCDSLML---- HHHHHHHHHCC----	21.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of I12R2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of I12R2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of I12R2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JAK2_HUMAN	JAK2	physical	10198225
SOCS3_HUMAN	SOCS3	physical	14559241

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.