RHOD_HUMAN - dbPTM
RHOD_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHOD_HUMAN
UniProt AC O00212
Protein Name Rho-related GTP-binding protein RhoD
Gene Name RHOD
Organism Homo sapiens (Human).
Sequence Length 210
Subcellular Localization Cell membrane
Lipid-anchor
Cytoplasmic side . Early endosome . Colocalizes with RAB5 to early endosomes (By similarity).
Protein Description Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution..
Protein Sequence MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCKKVPIIVVGCKTDLCKDKSLVNKLRRNGLEPVTYHRGQEMARSVGAVAYLECSARLHDNVHAVFQEAAEVALSSRGRNFWRRITQGFCVVT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationEAPPGVRSVKVVLVG
CCCCCCCEEEEEEEC		24.7118669648
19UbiquitinationPPGVRSVKVVLVGDG
CCCCCEEEEEEECCC		28.07-
47PhosphorylationGAFPESYTPTVFERY
CCCCCCCCCCHHHEE		23.0524719451
63UbiquitinationVNLQVKGKPVHLHIW
EEEEECCEEEEEEEE		37.842190698
78PhosphorylationDTAGQDDYDRLRPLF
CCCCCCCHHHCHHHC		15.9727642862
120UbiquitinationPEVNHFCKKVPIIVV
HHHHHHHCCCCEEEE		56.73-
121UbiquitinationEVNHFCKKVPIIVVG
HHHHHHCCCCEEEEE		55.19-
137UbiquitinationKTDLCKDKSLVNKLR
CCCCCCCHHHHHHHH		31.05-
138PhosphorylationTDLCKDKSLVNKLRR
CCCCCCHHHHHHHHH		47.9226657352
207MethylationRRITQGFCVVT----
HHHHCCEEEEC----		2.84-
207GeranylgeranylationRRITQGFCVVT----
HHHHCCEEEEC----		2.84-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RHOD_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHOD_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHOD_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DIAP2_HUMANDIAPH2physical
12577064
PLXA1_HUMANPLXNA1physical
11784792
ANFY1_HUMANANKFY1physical
24102721
SPTB1_HUMANSPTBphysical
26186194
PLXB2_HUMANPLXNB2physical
26186194
DAAM1_HUMANDAAM1physical
26186194
TTC19_HUMANTTC19physical
26186194
CETN3_HUMANCETN3physical
26186194
TR61B_HUMANTRMT61Bphysical
26186194
DIAP1_HUMANDIAPH1physical
26186194
PCBP3_HUMANPCBP3physical
26186194
CA198_HUMANC1orf198physical
26186194
CA198_HUMANC1orf198physical
28514442
SPTB1_HUMANSPTBphysical
28514442
DAAM1_HUMANDAAM1physical
28514442
PLXB2_HUMANPLXNB2physical
28514442
TR61B_HUMANTRMT61Bphysical
28514442
CETN3_HUMANCETN3physical
28514442
PCBP3_HUMANPCBP3physical
28514442
DIAP1_HUMANDIAPH1physical
28514442
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHOD_HUMAN

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Related Literatures of Post-Translational Modification

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