IDH3G_HUMAN - dbPTM
IDH3G_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IDH3G_HUMAN
UniProt AC P51553
Protein Name Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
Gene Name IDH3G
Organism Homo sapiens (Human).
Sequence Length 393
Subcellular Localization Mitochondrion .
Protein Description Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers..
Protein Sequence MALKVATVAGSAAKAVLGPALLCRPWEVLGAHEVPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHIRVINGRAVEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50UbiquitinationQTIPPSAKYGGRHTV
CCCCCCCCCCCEEEE		49.09-
92PhosphorylationDFEEVHVSSNADEED
CHHEEECCCCCCHHH		11.7321406692
93PhosphorylationFEEVHVSSNADEEDI
HHEEECCCCCCHHHH		34.6421406692
115MethylationRRNRVALKGNIETNH
HHCCEEECCCCCCCC		39.93115971341
115UbiquitinationRRNRVALKGNIETNH
HHCCEEECCCCCCCC		39.93-
149UbiquitinationYANVIHCKSLPGVVT
HHCEEECCCCCCCEE		40.65-
1592-HydroxyisobutyrylationPGVVTRHKDIDILIV
CCCEECCCCCEEEEE		53.76-
159UbiquitinationPGVVTRHKDIDILIV
CCCEECCCCCEEEEE		53.76-
170PhosphorylationILIVRENTEGEYSSL
EEEEECCCCCCCCCC		40.3826471730
174PhosphorylationRENTEGEYSSLEHES
ECCCCCCCCCCCHHH		17.8926471730
175PhosphorylationENTEGEYSSLEHESV
CCCCCCCCCCCHHHH		24.9328857561
176PhosphorylationNTEGEYSSLEHESVA
CCCCCCCCCCHHHHH		36.5526471730
181PhosphorylationYSSLEHESVAGVVES
CCCCCHHHHHHHHHH		21.1228857561
190UbiquitinationAGVVESLKIITKAKS
HHHHHHHHHHHHHHH		41.14-
199MethylationITKAKSLRIAEYAFK
HHHHHHHHHHHHHHH		32.91115480163
203PhosphorylationKSLRIAEYAFKLAQE
HHHHHHHHHHHHHHH		14.33-
206SuccinylationRIAEYAFKLAQESGR
HHHHHHHHHHHHHCC		34.4423954790
206UbiquitinationRIAEYAFKLAQESGR
HHHHHHHHHHHHHCC		34.44-
206MalonylationRIAEYAFKLAQESGR
HHHHHHHHHHHHHCC		34.4426320211
215UbiquitinationAQESGRKKVTAVHKA
HHHHCCCCEEHHHHC		43.38-
221UbiquitinationKKVTAVHKANIMKLG
CCEEHHHHCCHHHHC		36.21-
221AcetylationKKVTAVHKANIMKLG
CCEEHHHHCCHHHHC		36.21-
226UbiquitinationVHKANIMKLGDGLFL
HHHCCHHHHCCCHHH		45.59-
243PhosphorylationCREVAARYPQITFEN
HHHHHHHCCCCEEEE		8.5124719451
247PhosphorylationAARYPQITFENMIVD
HHHCCCCEEEEEEEC		21.4624719451
262PhosphorylationNTTMQLVSRPQQFDV
CCCEEECCCCCCCCE		47.0024719451
3152-HydroxyisobutyrylationTATRNTGKSIANKNI
EECCCCCCCCCCCCC		36.33-
320UbiquitinationTGKSIANKNIANPTA
CCCCCCCCCCCCHHH		40.48-
326PhosphorylationNKNIANPTATLLASC
CCCCCCHHHHHHHHH		31.8920068231
328PhosphorylationNIANPTATLLASCMM
CCCCHHHHHHHHHHH		25.4520068231
332PhosphorylationPTATLLASCMMLDHL
HHHHHHHHHHHHHHH		11.5220068231
343PhosphorylationLDHLKLHSYATSIRK
HHHHHHHHHHHHHHH		27.2228152594
344PhosphorylationDHLKLHSYATSIRKA
HHHHHHHHHHHHHHH		11.8028152594
346PhosphorylationLKLHSYATSIRKAVL
HHHHHHHHHHHHHHH		19.2228152594
347PhosphorylationKLHSYATSIRKAVLA
HHHHHHHHHHHHHHH		16.5428152594
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IDH3G_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IDH3G_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IDH3G_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SBDS_HUMANSBDSphysical
22939629
SUGP1_HUMANSUGP1physical
22939629
MYPT1_HUMANPPP1R12Aphysical
22939629
TIM44_HUMANTIMM44physical
22939629
RAB8A_HUMANRAB8Aphysical
22939629
NLTP_HUMANSCP2physical
22939629
PQBP1_HUMANPQBP1physical
22939629
SPRE_HUMANSPRphysical
22939629
ACON_HUMANACO2physical
26344197
IDHC_HUMANIDH1physical
26344197
IDH3A_HUMANIDH3Aphysical
26344197
IMA1_HUMANKPNA2physical
26344197
CH60_HUMANHSPD1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IDH3G_HUMAN

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Related Literatures of Post-Translational Modification

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