GPR37_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPR37_HUMAN
• UniProt AC: O15354
• Protein Name: Prosaposin receptor GPR37
• Gene Name: GPR37
• Organism: Homo sapiens (Human).
• Sequence Length: 613
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade..
• Protein Sequence: MRAPGALLARMSRLLLLLLLKVSASSALGVAPASRNETCLGESCAPTVIQRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPPGPWRWKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSHHKPLSKTANGLAGHEGWTIALPGRALAQNGSLGEGIHEPGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGRAPAERCIIKISPDLPDTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKACTRGNKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCKPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	GALLARMSRLLLLLL HHHHHHHHHHHHHHH	17.77	24043423
36	N-linked_Glycosylation	GVAPASRNETCLGES CCCCCCCCCCCCCCC	46.57	UniProtKB CARBOHYD
222	N-linked_Glycosylation	PGRALAQNGSLGEGI CHHHHHCCCCCCCCC	36.09	UniProtKB CARBOHYD
239	N-linked_Glycosylation	PGGPRRGNSTNRRVR CCCCCCCCCCCCCEE	43.80	UniProtKB CARBOHYD
240	Phosphorylation	GGPRRGNSTNRRVRL CCCCCCCCCCCCEEE	29.86	-
241	Phosphorylation	GPRRGNSTNRRVRLK CCCCCCCCCCCEEEC	36.42	-
597	Phosphorylation	ELELSPFSTIRREMS EEEECCCHHHHHHHH	26.72	23898821

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:12150907
-	K	Ubiquitination	E3 ubiquitin ligase	SYVN1	Q86TM6	PMID:15572843

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPR37_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPR37_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHIP_HUMAN	STUB1	physical	12150907
DNJA1_HUMAN	DNAJA1	physical	12150907
HSP7C_HUMAN	HSPA8	physical	12150907
DNJB1_HUMAN	DNAJB1	physical	12150907
SYVN1_HUMAN	SYVN1	physical	17059562
SYVN1_HUMAN	SYVN1	physical	18344614
SYVN1_HUMAN	SYVN1	physical	15572843
HSP74_HUMAN	HSPA4	physical	14532270
TCPA_HUMAN	TCP1	physical	14532270
TCPB_HUMAN	CCT2	physical	14532270
PACRG_HUMAN	PACRG	physical	14532270
PICK1_HUMAN	PICK1	physical	24749734
GRIP1_HUMAN	GRIP1	physical	24749734
SDCB1_HUMAN	SDCBP	physical	24749734
PICK1_RAT	Pick1	physical	24749734
NXF1_HUMAN	NXF1	physical	28514442
F219A_HUMAN	FAM219A	physical	28514442
PTPRD_HUMAN	PTPRD	physical	28514442
WDFY1_HUMAN	WDFY1	physical	28514442
ABCB8_HUMAN	ABCB8	physical	28514442
ATE1_HUMAN	ATE1	physical	28514442
2A5D_HUMAN	PPP2R5D	physical	28514442
DPOD2_HUMAN	POLD2	physical	28514442
MBOA7_HUMAN	MBOAT7	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.