RGS9_HUMAN - dbPTM
RGS9_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGS9_HUMAN
UniProt AC O75916
Protein Name Regulator of G-protein signaling 9
Gene Name RGS9
Organism Homo sapiens (Human).
Sequence Length 674
Subcellular Localization Isoform 3: Membrane
Peripheral membrane protein. Isoform 3 is targeted to the membrane via its interaction with RGS9BP..
Protein Description Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity)..
Protein Sequence MTIRHQGQQYRPRMAFLQKIEALVKDMQNPETGVRMQNQRVLVTSVPHAMTGSDVLQWIVQRLWISSLEAQNLGNFIVRYGYIYPLQDPKNLILKPDGSLYRFQTPYFWPTQQWPAEDTDYAIYLAKRNIKKKGILEEYEKENYNFLNQKMNYKWDFVIMQAKEQYRAGKERNKADRYALDCQEKAYWLVHRCPPGMDNVLDYGLDRVTNPNEVKVNQKQTVVAVKKEIMYYQQALMRSTVKSSVSLGGIVKYSEQFSSNDAIMSGCLPSNPWITDDTQFWDLNAKLVEIPTKMRVERWAFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACEDLKYGDQSKVKEKAEEIYKLFLAPGARRWINIDGKTMDITVKGLKHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKDMLAKAIEPQETTKKSSTLPFMRRHLRSSPSPVILRQLEEEAKAREAANTVDITQPGQHMAPSPHLTVYTGTCMPPSPSSPFSSSCRSPRKPFASPSRFIRRPSTTICPSPIRVALESSSGLEQKGECSGSMAPRGPSVTESSEASLDTSWPRSRPRAPPKARMALSFSRFLRRGCLASPVFARLSPKCPAVSHGRVQPLGDVGQQLPRLKSKRVANFFQIKMDVPTGSGTCLMDSEDAGTGESGDRATEKEVICPWESL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2 (in isoform 4)Phosphorylation-27.0729116813
3 (in isoform 4)Phosphorylation-3.4129116813
66PhosphorylationIVQRLWISSLEAQNL
HHHHHHHHHHHHHCC		19.79-
141AcetylationGILEEYEKENYNFLN
CCCHHHHHHHHCHHH		50.817379887
141UbiquitinationGILEEYEKENYNFLN
CCCHHHHHHHHCHHH		50.81-
153PhosphorylationFLNQKMNYKWDFVIM
HHHHHCCCCCCEEEC		15.23-
185UbiquitinationYALDCQEKAYWLVHR
HHHHHHHHHHHHHHC		22.39-
304PhosphorylationERWAFNFSELIRDPK
EEEEECHHHHHCCCC		32.37-
409UbiquitinationDSYARYLKSPIYKDM
HHHHHHHCCHHHHHH		45.30-
413PhosphorylationRYLKSPIYKDMLAKA
HHHCCHHHHHHHHHH		12.3417322306
419AcetylationIYKDMLAKAIEPQET
HHHHHHHHHHCCCCC		46.0320167786
432PhosphorylationETTKKSSTLPFMRRH
CCCCCCCCHHHHHHH		45.6130576142
445PhosphorylationRHLRSSPSPVILRQL
HHHHCCCCHHHHHHH		33.47-
475 (in isoform 3)Phosphorylation-10.17-
493PhosphorylationTCMPPSPSSPFSSSC
CCCCCCCCCCCCCCC		55.7922210691
494PhosphorylationCMPPSPSSPFSSSCR
CCCCCCCCCCCCCCC		33.0922210691
497PhosphorylationPSPSSPFSSSCRSPR
CCCCCCCCCCCCCCC		25.4022210691
498PhosphorylationSPSSPFSSSCRSPRK
CCCCCCCCCCCCCCC		33.5622210691
499PhosphorylationPSSPFSSSCRSPRKP
CCCCCCCCCCCCCCC		16.6122210691
502PhosphorylationPFSSSCRSPRKPFAS
CCCCCCCCCCCCCCC		33.1228787133
518PhosphorylationSRFIRRPSTTICPSP
CCCCCCCCCCCCCCC		36.0527251275
519PhosphorylationRFIRRPSTTICPSPI
CCCCCCCCCCCCCCE		23.9027251275
520PhosphorylationFIRRPSTTICPSPIR
CCCCCCCCCCCCCEE		25.5627251275
545PhosphorylationQKGECSGSMAPRGPS
CCCCCCCCCCCCCCC		8.76-
552PhosphorylationSMAPRGPSVTESSEA
CCCCCCCCCCCCCCC		44.4929083192
554PhosphorylationAPRGPSVTESSEASL
CCCCCCCCCCCCCCC		34.1929083192
556PhosphorylationRGPSVTESSEASLDT
CCCCCCCCCCCCCCC		24.9029083192
557PhosphorylationGPSVTESSEASLDTS
CCCCCCCCCCCCCCC		30.8329083192
560PhosphorylationVTESSEASLDTSWPR
CCCCCCCCCCCCCCC		23.7929083192
563PhosphorylationSSEASLDTSWPRSRP
CCCCCCCCCCCCCCC		37.6729083192
564PhosphorylationSEASLDTSWPRSRPR
CCCCCCCCCCCCCCC		34.4529083192
568PhosphorylationLDTSWPRSRPRAPPK
CCCCCCCCCCCCCCC		42.42-
581PhosphorylationPKARMALSFSRFLRR
CCHHHHHHHHHHHHC		16.1924945436
583PhosphorylationARMALSFSRFLRRGC
HHHHHHHHHHHHCCC		20.8130631047
593PhosphorylationLRRGCLASPVFARLS
HHCCCCCCHHHHHCC		14.5123898821
600PhosphorylationSPVFARLSPKCPAVS
CHHHHHCCCCCCCCC		19.4326091039
673PhosphorylationEVICPWESL------
EEECCCCCC------		35.1923663014
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGS9_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
478SPhosphorylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGS9_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GNB5_HUMANGNB5physical
21511947
R7BP_HUMANRGS7BPphysical
21511947
R9BP_HUMANRGS9BPphysical
21511947
GNAO_HUMANGNAO1physical
21511947
GNB5_HUMANGNB5physical
28514442
RBM25_HUMANRBM25physical
28514442
Drug and Disease Associations
Kegg Disease
H00973 Bradyopsia
OMIM Disease
608415Prolonged electroretinal response suppression (PERRS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGS9_HUMAN

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Related Literatures of Post-Translational Modification

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