R7BP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: R7BP_HUMAN
• UniProt AC: Q6MZT1
• Protein Name: Regulator of G-protein signaling 7-binding protein
• Gene Name: RGS7BP
• Organism: Homo sapiens (Human).
• Sequence Length: 257
• Subcellular Localization: Nucleus . Cytoplasm . Cell membrane ; Lipid-anchor . Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation.
• Protein Description: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation..
• Protein Sequence: MSSAPNGRKKRPSRSTRSSIFQISKPPLQSGDWERRGSGSESAHKTQRALDDCKMLVQEFNTQVALYRELVISIGDVSVSCPSLRAEMHKTRTKGCEMARQAHQKLAAISGPEDGEIHPEICRLYIQLQCCLEMYTTEMLKSICLLGSLQFHRKGKEPGGGTKSLDCKIEESAETPALEDSSSSPVDSQQHSWQVSTDIENTERDMREMKNLLSKLRETMPLPLKNQDDSSLLNLTPYPLVRRRKRRFFGLCCLISS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	Phosphorylation	LYRELVISIGDVSVS HHHHHEEEECCEEEE	17.03	28842319
78	Phosphorylation	VISIGDVSVSCPSLR EEEECCEEEECHHHH	17.04	28842319
80	Phosphorylation	SIGDVSVSCPSLRAE EECCEEEECHHHHHH	16.89	28842319
83	Phosphorylation	DVSVSCPSLRAEMHK CEEEECHHHHHHHHH	34.51	28842319
183	Phosphorylation	PALEDSSSSPVDSQQ CCCCCCCCCCCCCCC	42.48	24076635
230	Phosphorylation	PLKNQDDSSLLNLTP CCCCCCCCHHHCCCC	31.04	24043423
231	Phosphorylation	LKNQDDSSLLNLTPY CCCCCCCHHHCCCCH	43.82	24043423
236	Phosphorylation	DSSLLNLTPYPLVRR CCHHHCCCCHHHHHH	21.50	24076635
238	Phosphorylation	SLLNLTPYPLVRRRK HHHCCCCHHHHHHCH	12.17	24043423
252	S-palmitoylation	KRRFFGLCCLISS-- HHHHEEEEHHHCC--	1.49	-
253	S-palmitoylation	RRFFGLCCLISS--- HHHEEEEHHHCC---	4.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of R7BP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of R7BP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of R7BP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGS9_HUMAN	RGS9	physical	16867977
GNB5_HUMAN	GNB5	physical	16867977
RGS9_HUMAN	RGS9	physical	21511947
GNB5_HUMAN	GNB5	physical	21511947

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.