dbPTM

PKD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PKD1_HUMAN
UniProt AC	P98161
Protein Name	Polycystin-1
Gene Name	PKD1
Organism	Homo sapiens (Human).
Sequence Length	4303
Subcellular Localization	Cell membrane Multi-pass membrane protein . Cell projection, cilium . PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autoproteolytic cleavage at the GPS
Protein Description	Involved in renal tubulogenesis. [PubMed: 12482949 Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity Acts as a regulator of cilium length, together with PKD2 (By similarity The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.]
Protein Sequence	MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTCRGPTLLQHVFPASPGATLVGPHGPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRFLVSRVTRSLDVWIGFSTVQGVEVGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNRTQLAPACMPGGRWCPGANICLPLDASCHPQACANGCTSGPGLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAPGHPGPRAPYLSANASSWLPHLPAQLEGTWACPACALRLLAATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRDGRLYVPTNGSALVLQVDSGANATATARWPGGSVSARFENVCPALVATFVPGCPWETNDTLFSVVALPWLSEGEHVVDVVVENSASRANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFKLSLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAAPGEYLLTVLASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQFVQLGDEAWLVACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSIKVNGSLGLELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVGGGRYFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVEPVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQVPVSGLSIRASEPGGSFVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSGLQVPNCCEPGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQYVALQSGPCFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPARVALPGVDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFRPHFEVGLAVVVQDQLGAAVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDVAAEPKHERQHRAQIRKNITETLVSLRVHTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLIHLASSDVRAPQPSELGAESPSRMVASQAYNLTSALMRILMRSRVLNEEPLTLAGEEIVAQGKRSDPRSLLCYGGAPGPGCHFSIPEAFSGALANLSDVVQLIFLVDSNPFPFGYISNYTVSTKVASMAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNYTLLDGHYLSEEPEPYLAVYLHSEPRPNEHNCSASRRIRPESLQGADHRPYTFFISPGSRDPAGSYHLNLSSHFRWSALQVSVGLYTSLCQYFSEEDMVWRTEGLLPLEETSPRQAVCLTRHLTAFGASLFVPPSHVRFVFPEPTADVNYIVMLTCAVCLVTYMVMAAILHKLDQLDASRGRAIPFCGQRGRFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRIQRATCCVLLICLFLGANAVWYGAVGDSAYSTGHVSRLSPLSVDTVAVGLVSSVVVYPVYLAILFLFRMSRSKVAGSPSPTPAGQQVLDIDSCLDSSVLDSSFLTFSGLHAEQAFVGQMKSDLFLDDSKSLVCWPSGEGTLSWPDLLSDPSIVGSNLRQLARGQAGHGLGPEEDGFSLASPYSPAKSFSASDEDLIQQVLAEGVSSPAPTQDTHMETDLLSSLSSTPGEKTETLALQRLGELGPPSPGLNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVGASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSARVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYRLQSAIKQELHSRAFLAITRSEELWPWMAHVLLPYVHGNQSSPELGPPRLRQVRLQEALYPDPPGPRVHTCSAAGGFSTSDYDVGWESPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREGRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDSLWSVAQALLVLCPGTGLSTLCPAESWHLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTRCEPEPSRLQAVFEALLTQFDRLNQATEDVYQLEQQLHSLQGRRSSRAPAGSSRGPSPGLRPALPSRLARASRGVDLATGPSRTPLRAKNKVHPSST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	N-linked_Glycosylation	PGAACRVNCSGRGLR CCCCEEEECCCCCCH	8.55	UniProtKB CARBOHYD
89	N-linked_Glycosylation	LDVGLLANLSALAEL HHHHHHHHHHHHHHC	34.20	UniProtKB CARBOHYD
116	N-linked_Glycosylation	GIFANLFNLSEINLS CHHHHHCCCCCEECC	45.91	UniProtKB CARBOHYD
121	N-linked_Glycosylation	LFNLSEINLSGNPFE HCCCCCEECCCCCCC	24.89	UniProtKB CARBOHYD
187	N-linked_Glycosylation	YVACLPDNSSGTVAA EEEECCCCCCCCEEE	35.81	UniProtKB CARBOHYD
621	N-linked_Glycosylation	STAGTPENGSEPESR HCCCCCCCCCCCCCC	61.57	UniProtKB CARBOHYD
632	N-linked_Glycosylation	PESRSPDNRTQLAPA CCCCCCCCCCCCCCE	52.89	UniProtKB CARBOHYD
746	N-linked_Glycosylation	RAPYLSANASSWLPH CCCCCCCCHHHHCCC	36.66	UniProtKB CARBOHYD
810	N-linked_Glycosylation	GNGVSRHNLSCSFDV CCCCCCCCCEEECEE	32.32	UniProtKB CARBOHYD
841	N-linked_Glycosylation	GRLYVPTNGSALVLQ CCEEECCCCCEEEEE	36.03	UniProtKB CARBOHYD
843	Phosphorylation	LYVPTNGSALVLQVD EEECCCCCEEEEEEC	22.09	21712546
854	N-linked_Glycosylation	LQVDSGANATATARW EEECCCCCCEEEEEC	41.15	UniProtKB CARBOHYD
856	Phosphorylation	VDSGANATATARWPG ECCCCCCEEEEECCC	25.09	21712546
858	Phosphorylation	SGANATATARWPGGS CCCCCEEEEECCCCC	16.64	21712546
890	N-linked_Glycosylation	PGCPWETNDTLFSVV CCCCCCCCCCCEEEE	28.84	UniProtKB CARBOHYD
921	N-linked_Glycosylation	ENSASRANLSLRVTA ECCCCCCCEEEEEEE	29.11	UniProtKB CARBOHYD
1004	N-linked_Glycosylation	TASNHVSNVTVNYNV EECCCCCCEEEEEEE	32.18	UniProtKB CARBOHYD
1010	N-linked_Glycosylation	SNVTVNYNVTVERMN CCEEEEEEEEHHHHH	20.13	UniProtKB CARBOHYD
1034	N-linked_Glycosylation	VPAVLSPNATLALTA CCCCCCCCCCEEEHH	42.03	UniProtKB CARBOHYD
1072	N-linked_Glycosylation	HQFQPPYNESFPVPD HHCCCCCCCCCCCCC	44.18	UniProtKB CARBOHYD
1108	Phosphorylation	YLLTVLASNAFENLT HHHHHHHHCCCCCCC	25.24	-
1113	N-linked_Glycosylation	LASNAFENLTQQVPV HHHCCCCCCCCCCCC	41.77	UniProtKB CARBOHYD
1178	N-linked_Glycosylation	TQSQPAANHTYASRG CCCCCCCCCCCCCCC	30.09	UniProtKB CARBOHYD
1194	N-linked_Glycosylation	YHVRLEVNNTVSGAA EEEEEEECCCCCHHH	29.13	UniProtKB CARBOHYD
1240	N-linked_Glycosylation	AAVQTGDNITWTFDM EEEECCCCEEEEEEC	34.63	UniProtKB CARBOHYD
1269	N-linked_Glycosylation	HVYLRAQNCTVTVGA EEEEECCCCEEEECC	23.57	UniProtKB CARBOHYD
1336	N-linked_Glycosylation	TFGDGSSNTTVRGCP ECCCCCCCCEECCCC	41.27	UniProtKB CARBOHYD
1348	N-linked_Glycosylation	GCPTVTHNFTRSGTF CCCCCCCCCCCCCCC	30.53	UniProtKB CARBOHYD
1363	Phosphorylation	PLALVLSSRVNRAHY CCHHHEECCCCCCEE	35.77	24719451
1382	N-linked_Glycosylation	CVEPEVGNVTLQPER EECCCCCCEEECCCC	28.86	UniProtKB CARBOHYD
1441	Phosphorylation	IYRDPGSYLVTVTAS EEECCCCEEEEEEEC	15.88	22210691
1450	N-linked_Glycosylation	VTVTASNNISAANDS EEEEECCCCCCCCCC	27.39	UniProtKB CARBOHYD
1455	N-linked_Glycosylation	SNNISAANDSALVEV CCCCCCCCCCCEEEE	43.41	UniProtKB CARBOHYD
1469	Phosphorylation	VQEPVLVTSIKVNGS ECCCEEEEEEEECCE	22.15	22210691
1470	Phosphorylation	QEPVLVTSIKVNGSL CCCEEEEEEEECCEE	16.97	22210691
1474	N-linked_Glycosylation	LVTSIKVNGSLGLEL EEEEEEECCEECCEE	29.36	UniProtKB CARBOHYD
1518	N-linked_Glycosylation	PEVTHAYNSTGDFTV CCEEEEECCCCCEEE	33.60	UniProtKB CARBOHYD
1541	N-linked_Glycosylation	SRSEAWLNVTVKRRV CCCCCEECCEEHHHH	19.40	UniProtKB CARBOHYD
1554	N-linked_Glycosylation	RVRGLVVNASRTVVP HHCEEEEECCCCEEE	25.39	UniProtKB CARBOHYD
1563	N-linked_Glycosylation	SRTVVPLNGSVSFST CCCEEECCCEEEEEE	34.32	UniProtKB CARBOHYD
1647	N-linked_Glycosylation	GGRYFPTNHTVQLQA CCCEECCCCEEEEEE	29.13	UniProtKB CARBOHYD
1661	N-linked_Glycosylation	AVVRDGTNVSYSWTA EEEECCCCEEEEEEE	26.68	UniProtKB CARBOHYD
1684	Phosphorylation	AGSGKGFSLTVLEAG CCCCCCEEEEEEECC	31.62	26126808
1686	Phosphorylation	SGKGFSLTVLEAGTY CCCCEEEEEEECCEE	23.11	26126808
1692	Phosphorylation	LTVLEAGTYHVQLRA EEEEECCEEEEEEEC	19.94	26126808
1693	Phosphorylation	TVLEAGTYHVQLRAT EEEECCEEEEEEECC	10.08	26126808
1733	N-linked_Glycosylation	SPNPAAVNTSVTLSA CCCCCCCCCEEEEEE	23.16	UniProtKB CARBOHYD
1791	N-linked_Glycosylation	GNPLGSANATVEVDV CCCCCCCCEEEEEEE	37.53	UniProtKB CARBOHYD
1834	N-linked_Glycosylation	GQLATGTNVSWCWAV EECCCCCCEEEEEEC	27.46	UniProtKB CARBOHYD
1861	Phosphorylation	MVFPDAGTFSIRLNA EEECCCCEEEEEECC	18.87	-
1867	N-linked_Glycosylation	GTFSIRLNASNAVSW CEEEEEECCCCCCEE	31.32	UniProtKB CARBOHYD
1880	N-linked_Glycosylation	SWVSATYNLTAEEPI EEEEEEECCCCCCCC	26.93	UniProtKB CARBOHYD
1949	Phosphorylation	RVGDHVVSVRGKNHV CCCCEEEEECCCCCC	12.66	24719451
1991	N-linked_Glycosylation	IATGTERNFTARVQR CCCCCCCEEEECCCC	32.18	UniProtKB CARBOHYD
2004	Phosphorylation	QRGSRVAYAWYFSLQ CCCCCCEEEEEEEEE	8.53	-
2050	N-linked_Glycosylation	FNALGSENRTLVLEV HHHCCCCCCEEEEEH	43.89	UniProtKB CARBOHYD
2052	Phosphorylation	ALGSENRTLVLEVQD HCCCCCCEEEEEHHH	32.57	24043423
2063	Phosphorylation	EVQDAVQYVALQSGP EHHHHHHHHHHHCCC	4.90	24043423
2068	Phosphorylation	VQYVALQSGPCFTNR HHHHHHHCCCCCCCC	45.62	24043423
2073	Phosphorylation	LQSGPCFTNRSAQFE HHCCCCCCCCCHHEE	36.12	24043423
2074	N-linked_Glycosylation	QSGPCFTNRSAQFEA HCCCCCCCCCHHEEE	18.69	UniProtKB CARBOHYD
2086	Phosphorylation	FEAATSPSPRRVAYH EEECCCCCCCEEEEE	30.70	17081983
2089	Methylation	ATSPSPRRVAYHWDF CCCCCCCEEEEECCC	22.32	24384367
2109	Methylation	GQDTDEPRAEHSYLR CCCCCCCCHHCCCCC	51.03	24384377
2125	N-linked_Glycosylation	GDYRVQVNASNLVSF CCEEEEEEHHHHHEE	22.14	UniProtKB CARBOHYD
2164	Phosphorylation	LQVLMRRSQRNYLEA HHHHHHHHHCCHHEE	24.11	-
2168	Phosphorylation	MRRSQRNYLEAHVDL HHHHHCCHHEEEEEH	14.22	-
2248	N-linked_Glycosylation	LTQSIQANVTVAPER CHHHHEECCEECHHH	17.39	UniProtKB CARBOHYD
2320	Phosphorylation	LNFGPRGSSTVTIPR EECCCCCCCEEEEEH	24.90	20166139
2321	Phosphorylation	NFGPRGSSTVTIPRE ECCCCCCCEEEEEHH	29.71	20166139
2324	Phosphorylation	PRGSSTVTIPRERLA CCCCCEEEEEHHHHC	25.92	20166139
2336	Phosphorylation	RLAAGVEYTFSLTVW HHCCCCEEEEEEEEE	15.64	25954137
2337	Phosphorylation	LAAGVEYTFSLTVWK HCCCCEEEEEEEEEE	8.01	25954137
2339	Phosphorylation	AGVEYTFSLTVWKAG CCCEEEEEEEEEECC	18.48	25954137
2353	N-linked_Glycosylation	GRKEEATNQTVLIRS CCCCCCCCCEEEEEC	42.44	UniProtKB CARBOHYD
2395	N-linked_Glycosylation	YLEGRCLNCSSGSKR EEEEEEEECCCCCCC	27.53	UniProtKB CARBOHYD
2412	N-linked_Glycosylation	WAARTFSNKTLVLDE EEEEEECCCEEEEEE	36.82	UniProtKB CARBOHYD
2414	Phosphorylation	ARTFSNKTLVLDETT EEEECCCEEEEEECC	26.75	-
2420	Phosphorylation	KTLVLDETTTSTGSA CEEEEEECCCCCCCH	34.73	-
2426	Phosphorylation	ETTTSTGSAGMRLVL ECCCCCCCHHHEEEE	23.03	-
2488	Phosphorylation	LGAVHALTTKVHFEC CCHHEEEECEEEEEE	25.92	-
2489	Phosphorylation	GAVHALTTKVHFECT CHHEEEECEEEEEEC	31.74	-
2567	N-linked_Glycosylation	GAAVVALNRSLAITL HHHHHEEECEEEEEC	23.04	UniProtKB CARBOHYD
2578	N-linked_Glycosylation	AITLPEPNGSATGLT EEECCCCCCCCCCEE	56.22	UniProtKB CARBOHYD
2645	N-linked_Glycosylation	HRAQIRKNITETLVS HHHHHHHHHHHHHHH	36.24	UniProtKB CARBOHYD
2652	Phosphorylation	NITETLVSLRVHTVD HHHHHHHHCCCCCHH	17.36	24719451
2702	Phosphorylation	MLILQAETTAGTVTP HHHHHHHCCCCCCCC	25.59	24043423
2703	Phosphorylation	LILQAETTAGTVTPT HHHHHHCCCCCCCCC	18.00	24043423
2706	Phosphorylation	QAETTAGTVTPTAIG HHHCCCCCCCCCCCC	20.81	24043423
2708	Phosphorylation	ETTAGTVTPTAIGDS HCCCCCCCCCCCCHH	18.11	24043423
2710	Phosphorylation	TAGTVTPTAIGDSIL CCCCCCCCCCCHHHH	22.88	24043423
2715	Phosphorylation	TPTAIGDSILNITGD CCCCCCHHHHHCCHH	24.62	24043423
2718	N-linked_Glycosylation	AIGDSILNITGDLIH CCCHHHHHCCHHHHH	28.27	UniProtKB CARBOHYD
2720	Phosphorylation	GDSILNITGDLIHLA CHHHHHCCHHHHHHH	24.46	24043423
2728	Phosphorylation	GDLIHLASSDVRAPQ HHHHHHHCCCCCCCC	33.17	24043423
2729	Phosphorylation	DLIHLASSDVRAPQP HHHHHHCCCCCCCCH	34.22	24043423
2754	N-linked_Glycosylation	MVASQAYNLTSALMR HHHHHHHHHHHHHHH	39.60	UniProtKB CARBOHYD
2841	N-linked_Glycosylation	FPFGYISNYTVSTKV CCCCEEECEEECCCH	27.26	UniProtKB CARBOHYD
2868	Phosphorylation	IPIERLASERAITVK CCHHHHHCCCCEEEE	32.01	24719451
2878	N-linked_Glycosylation	AITVKVPNNSDWAAR CEEEECCCCCCCHHC	64.72	UniProtKB CARBOHYD
2925	N-linked_Glycosylation	AGLHLQLNYTLLDGH CEEEEEEEEEEECCC	18.12	UniProtKB CARBOHYD
2956	N-linked_Glycosylation	EPRPNEHNCSASRRI CCCCCCCCCCCCCCC	18.43	UniProtKB CARBOHYD
2994	N-linked_Glycosylation	PAGSYHLNLSSHFRW CCCCEEEECCHHHCC	25.27	UniProtKB CARBOHYD
3075	Phosphorylation	EPTADVNYIVMLTCA CCCCCCHHHHHHHHH	8.50	26074081
3080	Phosphorylation	VNYIVMLTCAVCLVT CHHHHHHHHHHHHHH	4.74	26074081
3087	Phosphorylation	TCAVCLVTYMVMAAI HHHHHHHHHHHHHHH	7.92	26074081
3088	Phosphorylation	CAVCLVTYMVMAAIL HHHHHHHHHHHHHHH	4.73	26074081
3143	Phosphorylation	AHVGIMLYGVDSRSG EEEEEEEEEECCCCC	9.56	-
3344 (in isoform 2)	Phosphorylation	-	4.89	22210691
3354 (in isoform 3)	Phosphorylation	-	16.68	22210691
3359 (in isoform 2)	Phosphorylation	-	37.46	22210691
3369 (in isoform 3)	Phosphorylation	-	19.53	22210691
3398	Phosphorylation	AFVGQMKSDLFLDDS HHHHCCCCCEECCCC	33.92	25159151
3405	Phosphorylation	SDLFLDDSKSLVCWP CCEECCCCCCEEEEC	24.66	29514088
3417	Phosphorylation	CWPSGEGTLSWPDLL EECCCCCCCCCHHHH	17.20	-
3419	Phosphorylation	PSGEGTLSWPDLLSD CCCCCCCCCHHHHCC	36.08	-
3456	Phosphorylation	EEDGFSLASPYSPAK CCCCCCCCCCCCCCC	13.78	32142685
3457	Phosphorylation	EDGFSLASPYSPAKS CCCCCCCCCCCCCCC	29.66	32142685
3633	Phosphorylation	EDDTLVESPAVTPVS CCCCCCCCCCCCCCC	15.64	24719451
3703	Phosphorylation	GHAYRLQSAIKQELH HHHHHHHHHHHHHHH	36.23	29449344
3711	Phosphorylation	AIKQELHSRAFLAIT HHHHHHHHCHHHHHH	37.62	29449344
3738	N-linked_Glycosylation	LLPYVHGNQSSPELG HHHHHCCCCCCCCCC	24.55	UniProtKB CARBOHYD
3790	N-linked_Glycosylation	VGWESPHNGSGTWAY CCCCCCCCCCCCEEE	50.11	UniProtKB CARBOHYD
3845	N-linked_Glycosylation	QLHNWLDNRSRAVFL HHHHHHCHHHHHHHH	41.47	UniProtKB CARBOHYD
3857	Phosphorylation	VFLELTRYSPAVGLH HHHHHHCCCCCCCCE	17.48	22210691
3868	Phosphorylation	VGLHAAVTLRLEFPA CCCEEEEEEEEECCC	11.05	22210691
4013	Phosphorylation	LRFVRQWSVFGKTLC HHHHHHHHHHHHHHH	10.14	26852163
4165	Phosphorylation	MEPLPSRSSRGSKVS CCCCCCCCCCCCCCC	28.82	24275569
4166	Phosphorylation	EPLPSRSSRGSKVSP CCCCCCCCCCCCCCC	39.28	11571556
4169	Phosphorylation	PSRSSRGSKVSPDVP CCCCCCCCCCCCCCC	28.86	22675472
4198	Phosphorylation	SSQLDGLSVSLGRLG HHHCCCEEEECCCCC	18.39	24275569
4200	Phosphorylation	QLDGLSVSLGRLGTR HCCCEEEECCCCCCC	23.02	24275569
4206	Phosphorylation	VSLGRLGTRCEPEPS EECCCCCCCCCCCCH	36.42	24275569
4237	Phosphorylation	NQATEDVYQLEQQLH HHHHHHHHHHHHHHH	21.50	22817900
4251	Phosphorylation	HSLQGRRSSRAPAGS HHHCCCCCCCCCCCC	23.86	-
4252	Phosphorylation	SLQGRRSSRAPAGSS HHCCCCCCCCCCCCC	30.56	22817900
4263	Phosphorylation	AGSSRGPSPGLRPAL CCCCCCCCCCCCCCH	34.13	-
4285	Phosphorylation	SRGVDLATGPSRTPL HCCCCCCCCCCCCCC	57.85	29083192
4288	Phosphorylation	VDLATGPSRTPLRAK CCCCCCCCCCCCCCC	50.56	21955146
4290	Phosphorylation	LATGPSRTPLRAKNK CCCCCCCCCCCCCCC	30.89	27174698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
4166	S	Phosphorylation	Kinase	PRKX	P51817	Uniprot
4237	Y	Phosphorylation	Kinase	SRC	P12931	PSP
4252	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
4252	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH1	Q8IUQ4	PMID:15284290

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PKD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PKD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PKD2_HUMAN	PKD2	physical	9192675
RGS7_HUMAN	RGS7	physical	10339594
FINC_HUMAN	FN1	physical	11752017
CO1A1_HUMAN	COL1A1	physical	11752017
K1C18_HUMAN	KRT18	physical	11581269
CO2A1_HUMAN	COL2A1	physical	11406351
SIAH1_HUMAN	SIAH1	physical	15284290
HDAC9_HUMAN	HDAC9	physical	15738054
HDAC9_HUMAN	HDAC9	physical	15623513
MARK2_HUMAN	MARK2	physical	19011111
PKD2_MOUSE	Pkd2	physical	11901144
PKD2_HUMAN	PKD2	physical	11901144
PKD1_HUMAN	PKD1	physical	11901144
AT1A1_HUMAN	ATP1A1	physical	11901144
PK2L1_MOUSE	Pkd2l1	physical	15548533
JADE1_HUMAN	JADE1	physical	23001567
CTNB1_HUMAN	CTNNB1	physical	11113628

Drug and Disease Associations

Kegg Disease
H00542	Polycystic kidney disease
OMIM Disease
173900	Polycystic kidney disease 1 (PKD1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PKD1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Protein kinase X (PRKX) can rescue the effects of polycystic kidneydisease-1 gene (PKD1) deficiency."; Li X., Burrow C.R., Polgar K., Hyink D.P., Gusella G.L., Wilson P.D.; Biochim. Biophys. Acta 1782:1-9(2008). Cited for: PHOSPHORYLATION AT SER-4166, AND INTERACTION WITH PRKX.	17980165 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4288, AND MASSSPECTROMETRY.	17081983 [Abstract]