PK2L1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PK2L1_MOUSE
• UniProt AC: A2A259
• Protein Name: Polycystic kidney disease 2-like 1 protein
• Gene Name: Pkd2l1
• Organism: Mus musculus (Mouse).
• Sequence Length: 760
• Subcellular Localization: Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane.
• Protein Description: Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. May play a role in the perception of carbonation taste..
• Protein Sequence: MNSMESPKNQELQTLGNRAWDNPAYSDPPSPNRTLRICTVSSVALPETQPKKPEVRCQEKTQRTLVSSCCLHICRSIRGLWGTTLTENTAENRELYVKTTLRELVVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDSGVSFQTISSMSDFWDFAQGPLLDSLYWTKWYNNQSLGRGSHSFIYYENLLLGAPRLRQLRVRNDSCVVHEDFREDILNCYDVYSPDKEDQLPFGPQNGTAWTYHSQNELGGSSHWGRLTSYSGGGYYLDLPGSRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILRLVVEFPATGGTIPSWQIRTVKLIRYVNNWDFFIVGCEVVFCVFIFYYVVEEILEIHLHRLRYLSSVWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPDTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVENFSTFVKCIFTQFRIILGDFDYNAIDNANRILGPVYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDQLQLSDFLKQSYNKTLLRLRLRKERVSDVQKVLKGGEPEIQFEDFTSTLRELGHEEHEITAAFTRFDQDGDHILDEEEQEQMRQGLEEERVTLNAEIENLGRSVGHSPPGELGAEAARGQSWVSGEEFDMLTRRVLQLQCVLEGVVSQIDAVGSKLKMLERKGELAPSPGMGEPAVWENLYNPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	S-palmitoylation	PNRTLRICTVSSVAL CCCEEEEEEEECCCC		-
177	N-linked_Glycosylation	YWTKWYNNQSLGRGS HEEEECCCCCCCCCC		29567962
207	N-linked_Glycosylation	LRQLRVRNDSCVVHE HHEEECCCCCEEECC		29567962
241	N-linked_Glycosylation	QLPFGPQNGTAWTYH CCCCCCCCCCCEEEE		29567962
505	N-linked_Glycosylation	LFGTQVENFSTFVKC HHCCCCCCHHHHHHH		-
508	Phosphorylation	TQVENFSTFVKCIFT CCCCCHHHHHHHHHH		23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PK2L1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PK2L1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PK2L1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PK2L1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.