VIPR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VIPR1_HUMAN
• UniProt AC: P32241
• Protein Name: Vasoactive intestinal polypeptide receptor 1
• Gene Name: VIPR1
• Organism: Homo sapiens (Human).
• Sequence Length: 457
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38..
• Protein Sequence: MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	S-palmitoylation	PLPARWLCVLAGALA CCCHHHHHHHHHHHH	1.55	28473666
37	S-palmitoylation	AARLQEECDYVQMIE HHHHHHHCCCEEEEH	4.50	28473666
58	N-linked_Glycosylation	LEEAQLENETIGCSK HHHHHCCCCCCCCCC	61.37	UniProtKB CARBOHYD
69	N-linked_Glycosylation	GCSKMWDNLTCWPAT CCCCCCCCCEEEECC	23.03	UniProtKB CARBOHYD
100	N-linked_Glycosylation	FSSIQGRNVSRSCTD HHHCCCCCCCCCCCC	42.83	UniProtKB CARBOHYD
144	Phosphorylation	MFYGSVKTGYTIGYG HHHCCCCCCCCCCCH	33.01	25072903
146	Phosphorylation	YGSVKTGYTIGYGLS HCCCCCCCCCCCHHH	10.62	25072903
147	Phosphorylation	GSVKTGYTIGYGLSL CCCCCCCCCCCHHHH	14.85	25072903
150	Phosphorylation	KTGYTIGYGLSLATL CCCCCCCCHHHHHHH	15.84	25072903
153	Phosphorylation	YTIGYGLSLATLLVA CCCCCHHHHHHHHHH	16.17	25072903
156	Phosphorylation	GYGLSLATLLVATAI CCHHHHHHHHHHHHH	26.39	25072903
161	Phosphorylation	LATLLVATAILSLFR HHHHHHHHHHHHHHH	13.52	25072903
165	Phosphorylation	LVATAILSLFRKLHC HHHHHHHHHHHHHCC	21.24	24719451
250	Phosphorylation	LLAVSFFSERKYFWG HHHHHHHCCCCCEEE	34.19	15932876
290	N-linked_Glycosylation	YGCWDTINSSLWWII CCCHHHHCHHHHHHH	27.86	UniProtKB CARBOHYD
331	Phosphorylation	RPPDIRKSDSSPYSR CCCCCCCCCCCHHHH	32.64	27259358
333	Phosphorylation	PDIRKSDSSPYSRLA CCCCCCCCCHHHHHH	40.06	27259358
334	Phosphorylation	DIRKSDSSPYSRLAR CCCCCCCCHHHHHHH	32.61	27259358
336	Phosphorylation	RKSDSSPYSRLARST CCCCCCHHHHHHHHH	14.36	27259358
337	Phosphorylation	KSDSSPYSRLARSTL CCCCCHHHHHHHHHH	24.97	27259358
418	Phosphorylation	VLGWNPKYRHPSGGS CCCCCCCCCCCCCCC	18.53	25022875
422	Phosphorylation	NPKYRHPSGGSNGAT CCCCCCCCCCCCCCC	50.05	25022875
425	Phosphorylation	YRHPSGGSNGATCST CCCCCCCCCCCCCCH	35.30	25022875
429	Phosphorylation	SGGSNGATCSTQVSM CCCCCCCCCCHHHHH	14.37	15932876
431	Phosphorylation	GSNGATCSTQVSMLT CCCCCCCCHHHHHHE	19.95	25022875
432	Phosphorylation	SNGATCSTQVSMLTR CCCCCCCHHHHHHEE	34.83	25022875
435	Phosphorylation	ATCSTQVSMLTRVSP CCCCHHHHHHEECCC	9.77	15932876
438	Phosphorylation	STQVSMLTRVSPGAR CHHHHHHEECCCCCC	22.00	25022875
441	Phosphorylation	VSMLTRVSPGARRSS HHHHEECCCCCCCCC	17.83	25022875
447	Phosphorylation	VSPGARRSSSFQAEV CCCCCCCCCCCEEEE	25.44	22777824
448	Phosphorylation	SPGARRSSSFQAEVS CCCCCCCCCCEEEEE	33.10	22777824
449	Phosphorylation	PGARRSSSFQAEVSL CCCCCCCCCEEEEEC	23.71	22777824
455	Phosphorylation	SSFQAEVSLV----- CCCEEEEECC-----	18.21	15932876

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VIPR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VIPR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VIPR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WASL_HUMAN	WASL	physical	10867004
SECR_HUMAN	SCT	physical	12133828
GNAQ_HUMAN	GNAQ	physical	11812005
GNAS3_HUMAN	GNAS	physical	11812005
GNAS2_HUMAN	GNAS	physical	11812005
ALEX_HUMAN	GNAS	physical	11812005
GNAS1_HUMAN	GNAS	physical	11812005
REEP6_HUMAN	REEP6	physical	28514442
SC5D_HUMAN	SC5D	physical	28514442
BIG3_HUMAN	KIAA1244	physical	28514442
XPO6_HUMAN	XPO6	physical	28514442
MFSD5_HUMAN	MFSD5	physical	28514442
RNF13_HUMAN	RNF13	physical	28514442
DYM_HUMAN	DYM	physical	28514442
YIPF3_HUMAN	YIPF3	physical	28514442
HACD2_HUMAN	PTPLB	physical	28514442
CTR2_HUMAN	SLC7A2	physical	28514442
ATPB_HUMAN	ATP5B	physical	28514442
ATP8_HUMAN	ATP8	physical	28514442
PLCD_HUMAN	AGPAT4	physical	28514442
EBP_HUMAN	EBP	physical	28514442
AT5F1_HUMAN	ATP5F1	physical	28514442
PM34_HUMAN	SLC25A17	physical	28514442
MPZL1_HUMAN	MPZL1	physical	28514442
SNG2_HUMAN	SYNGR2	physical	28514442
PRAF3_HUMAN	ARL6IP5	physical	28514442
SGMR2_HUMAN	TMEM97	physical	28514442
GLMN_HUMAN	GLMN	physical	28514442
COX1_HUMAN	COX1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.