TPP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPP1_MOUSE
• UniProt AC: O89023
• Protein Name: Tripeptidyl-peptidase 1
• Gene Name: Tpp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 562
• Subcellular Localization: Lysosome . Melanosome .
• Protein Description: Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus..
• Protein Sequence: MGLQARLLGLLALVIAGKCTYNPEPDQRWMLPPGWVSLGRVDPEEELSLTFALKQRNLERLSELVQAVSDPSSPQYGKYLTLEDVAELVQPSPLTLLTVQKWLSAAGARNCDSVTTQDFLTCWLSVRQAELLLPGAEFHRYVGGPTKTHVIRSPHPYQLPQALAPHVDFVGGLHRFPPSSPRQRPEPQQVGTVSLHLGVTPSVLRQRYNLTAKDVGSGTTNNSQACAQFLEQYFHNSDLTEFMRLFGGSFTHQASVAKVVGKQGRGRAGIEASLDVEYLMSAGANISTWVYSSPGRHEAQEPFLQWLLLLSNESSLPHVHTVSYGDDEDSLSSIYIQRVNTEFMKAAARGLTLLFASGDTGAGCWSVSGRHKFRPSFPASSPYVTTVGGTSFKNPFLITDEVVDYISGGGFSNVFPRPPYQEEAVAQFLKSSSHLPPSSYFNASGRAYPDVAALSDGYWVVSNMVPIPWVSGTSASTPVFGGILSLINEHRILNGRPPLGFLNPRLYQQHGTGLFDVTHGCHESCLNEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
209	N-linked_Glycosylation	SVLRQRYNLTAKDVG HHHHHHCCCCHHHCC	32.86	-
221	N-linked_Glycosylation	DVGSGTTNNSQACAQ HCCCCCCCHHHHHHH	46.09	16170054
285	N-linked_Glycosylation	YLMSAGANISTWVYS HHHHCCCCEEEEEEC	28.03	-
312	N-linked_Glycosylation	QWLLLLSNESSLPHV HHHHHHCCCCCCCCE	53.81	-
345	Acetylation	RVNTEFMKAAARGLT CCCHHHHHHHHHCCE	39.95	21728379
442	N-linked_Glycosylation	LPPSSYFNASGRAYP CCHHHHCCCCCCCCC	25.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNF8_MOUSE	Rnf8	physical	22101936

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"High throughput quantitative glycomics and glycoform-focusedproteomics of murine dermis and epidermis.";
Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K.,Monde K., Nishimura S.;
Mol. Cell. Proteomics 4:1977-1989(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-221, AND MASSSPECTROMETRY.
PubMed: 16170054