FAT2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAT2_RAT
• UniProt AC: O88277
• Protein Name: Protocadherin Fat 2
• Gene Name: Fat2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 4351
• Subcellular Localization: Cell membrane ; Single-pass membrane protein . Cell junction. Nucleus.
• Protein Description: May modulate the extracellular space surronding parallel fibers of cerebellar during development. Plays a role in the migration of epidermal cells (By similarity)..
• Protein Sequence: MTLVLLGLAILLLHRAACEKSLEETIPPLSWRFTHSLYNATIYENSAPKTYVESPVKMGMYLAEPHWVVKYRIISGDAAGVFKTEEHVVGNFCFLRIRTKSSNTALLNREVRDSYTLIVQASDKSLEFEALTQVVVHILDQNDLKPLFSPPSYRVTISEDRPLKSPICKVTATDADLGQNAEFYYAFNARSEVFAIHPTSGVVTVAGKLNVTRRGKYELQVLAVDRMRKISEGNGFGNLASLVIRVEPVHRKPPAINLVVLNPPEGDEGDIYAIVTVDTNGSGAEVDSLEVVGGDPGKYFKVLRSYAQGNEFNLVAVRDINWAEHPHGFNISLQTHSWSRFPPHSIIRAFHLPSWKLANLRFEKAVYRVKLSEFSPPGSRVALVKVTTALPNLRYSLKPSSRNTAFKLNARTGLITTTKLVDFHEQNQYQLHVKTSLGQATTTVIIDIVDCNNHAPVFNRSSYEGTLDENIPPGTSVLTVTATDQDHGDNGHITYSIAGPKAVPFSIDPLLGVISTTKPMDYELMKRIYTFRVRASDWGSPFRQEKEVSVSLRLKNLNDNQPMFEEVNCTVSLRQDVPVGKSIMAVSAIDMDELQNLKYEIVSGNEQDYFHLNHFSGVISLKRSFMNLTAVRPTIYSLKITASDGKNYASPTTLKVTVVKDPHSEVPVQCDKTGVLTHITKTILQSAGLQSQELGEEEFTSLSNYQINHHSPQFEDHFPQSIDILEQVPINTPLARLAATDPDTGFHGKLVYVISDGNEEGCFDIELETGLLMVAAALDYETTSFYVLNVTVYDLGTPPKSSWKLLTVTVKDWNDNPPRFPPGGYQLTISEDTEVGTTIAELKTEDADSEDNRRVRYTLLTPTEKFSLHPFTGELVVTGHLDRESESQYILKAEARDQPTKGHQLFSVTDLIVTLEDINDNPPQCITEHRRLKVPEDMPLGTVLTFLDASDPDLGPAGEVKYILVEDAHGTFQVHPMTGALSLEKELDFERRAGYNLSFWASDSGKPLSRRTLCHVEVLVMDVNENLHSPHFSSFVYQGQVQENSPAGTPVMVVTAQDDDSGLDGELQYFLRAGTGLETFSINQDTGMLETLAPLDREFTPYYWLTVLAVDRGSVPLSAVTEVYIEVTDINDNIPSMSRPVFYPSVLEDAPLGTSVLQLEAWDPDSSSQGKLTFNLTSGNHLGHFIVHPFTGLLTTAKQLDRENKDEYVLEVTVQDNGDPSLRSTSRVVVCILDVNDNPPMFSHKLFNVRLSERLSPLSPEPVYRLVASDPDEGLNGSVTYSIEESDEESFRIDPVTGVVSSSSTFAAGEYNILTIKATDSGQPALSTSVRLHIEWIPQPRPSSIPLSFDESYYSFTVMETDPVNHMVGVISVEGRPGLFWFHISDGDKDMDFDIEKTTGSIVIARPLDTRRKSSYNLTVEVTDGFHTIATQVHIFMIANINHHRPQFLQDHYEIRVPQDTLPGVELLRVQATDQDHGKGLIYTILSSQDPGSANLFQLDPSSGVLVTVGTLELHSGPSQHILTVMVRDQEMPIKRNFVWVTIHVEDGNLHSPHFTQLRYEANVPDTTAPGTELLQVRAVDADRGANAEIHYSFLKGNSDGFFNIDSLLGIITVAQRLYHVHLTRHALTVKAEDQGSPRRHDLALVVIHVHPSDSSAPVFSKDEYFIEIPESVPIGSPILLLSAGSSSEVTYELREGNKDSVFSMNSYSGLISTQKRLDHEKVPSYRLRIRGSNMAGVFTEVVALVYIIDENDNPPAFGKPTFLGHISEAAPLHSLILGEDNSPLVVRASDSDREANSLLVYKILEPEALKFFKIDPSMGTLTTTSELDFEDTPLFQFNIYVHDQGTPILFAPRSAKVIIHVRDVNDSPPRFSEQIYEVAVVEPIHPGMGLLTVQAEDNDSRVTYSIKTSNADEAVTIHPTTGQISVVNPATLRLFQKFSIRASDGLYHDTAVVKISLTQVLDKSLQFDQDVYRARVTENTPHRKALVILGVHGNHLNDTLSYFLLNGTDLFHMIESAGVLQTRGGTFDREQQDTHEVAVEVRDNRVPQRVAQALVRVSVEDVNDNIPEFQHLPYYTVIQDGTEPGDVLFQVSATDKDLGANGSVTYGFAEDYAYFRIDPYVGDISLKKPFDYQALNKYHLRVIARDSGIPPLQTEVEVHVTVRNKSNPLFQSPYYKVKVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDTALGSFSEATVEVLVEDINDNPPTFSQLVYTTSVSEGSPAQTPVIQLLASDQDSGQNQDVSYQIVEDGSDVSKFFRINGSTGEIFTIQELDYETHQHFRVKVRAMDKGDPPLTGETLVVVNVSDINDNPPKFREPQYEANVSELATCGHLVLKVQALDPDIGDTSRLEYLILSGNQDRHFSINSTSGIISMFNLCKKQLDSSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQNVYEAELAENAKVGTKVIELLAIDKDSGPYGTVDYTIINKLAGERFFINPRGQITTLQKLDRENSTERVIAIKVMARDGGGKVAFCTVKIILTDENDNAPQFKASGYTVSIPSNVSRDSPIIQVLAYDADEGRNADVTYSVDSTEDLAEEIIEVNPTTGVVKVKESLVGLENRAVDFNIKAQDGGPPHWDSLVPVRLQVVPNEIPLPKFSEPLYTFSAPEDLPEGSEIGSVKAVAAQDPIIYSLVQGTTPESNSDDVFSLDQDTGVLKVRKAMDHESTKWYQIDLMAHCPHEDTDLVSLVSVSIQVEDVNDNRPVFEADPYKAFLTENMPGGTTVIQVTANDQDTGSDGQVSYRLSVEPGSNIHELFAVDSESGWITTLQELDCETQQTYRFYVVAFDHGQTIQLSSQALVEVSITDENDNPPRFASEDYRGSVVENNEPGELVATLKTLDADVSDQNRQVTCYITEGDPLGQFSISQVGDEWRISSRKTLDREHIAKYLLRVTASDGKFQASVPVEVFVVDINDNSPQCSQLLYTGKVREDVTPGHFILKVSAIDVDMDTNAQITYSLHGPGAQEFKLDPHTGELTTLTVLDRERKDVYNLVAKATDGGGQSCQAEVTLHIEDVNDNAPRFFPSHCDVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLTDSADGQFSIDATSGVIRLEKPLQVRASSAVELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPIFLNAEHSTQVPEDAPIDMEVLHLATLTRPGSEKTGYHITGGNEQGKFRLDAHTGILYVNGSLDFETNPKYFLSIECSRKSSSSLSDVTTIVINVTDVNEHHPRFTHDLYTVRVLENAVVGDVILTVSASDDDGPVNSAITYSLVGGNQLGHFTINPKKGKLQVAKALDWEQTPSYSLRLRATDSGQPPLHEDTEVAVEVVDVNDNPPRFFQLNYSTSVQENSPIGIKVLQLILDDPDSPQNGPPYFFRITEGNTGSVFRVTPDGWLVTAASLSKKAREWYQLHIEVSDSGLPPLSSSTLVRVQVTEQSRYPPSTLPLEISITKGEEEFQGGMIGKIHATDRDPQDTLTYSLEQEGGLDRYFTVGASDGKIIASQGLPHGRYSFNVTVSDGTFTTTTGVHVHVWHMEPEVPQQAVWLGFHQLTPEELVSDHWRNLQRFLSNLLDVKRANIHLASLQPAEVTAGVDVLLVFERHSGTSYDLQELASAIAHSVREIEHSVGIRMRSALPVVPCQGQSCQDQTCQETVSLEPRVGPSYSTARLSILTPRHHLGRNCSCNGTTLRFSGQSYVQYRPLEAQNWQIHFYLKTLQPWALLMFTNETASISLKLANGFSHLEYHCPGGFYGNLSSRYPVNDGQWHSMLLEERDTSVHLLVDITDNASLVIPEECQGLRTERQLLLGGLVPSNPSSNVSLGFEGCLDAVVVNGERLELLGREKKMEGRLETWALSQCCWPGTACSQSPCLNGGSCSPALGSGYLCRCPPPFSGRNCELGRENCTSAPCQEGGTCVSSPEGTSCNCPHPYTGDRCEMEARGCSGGHCLITPEIKRGDWGQQEFLVITVALPLVIIATVGLLLYCRRRKSHKPVTMEDPDLLARSIGVDTQASPAIELDPLNTSSCNNLNQPEPSKTSVPNELVTFGPSSKQRPMVCSVPPRLPPAAVSSHPGHEPIIKRTWSGEELVYPSGAAVWPPTYSRKKHWEYPHPETMQGTLPPSPRRHVGPAVMPDPTGLYGGFPFPLELENKRAPLPPRYSNQNLEDLMPPRPPSPREHLLAPCLNEYTAISYYHSQFRQGGGGPCLAEGGYKGVSMRLSRAGPSYADCEVNGGPATGRSQPRAPPNYEGSDMVESDYGSCEEVMF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	N-linked_Glycosylation	RFTHSLYNATIYENS EEEEEEEEEEEECCC	35.58	-
210	N-linked_Glycosylation	VTVAGKLNVTRRGKY EEEEEEEECCCCCCE	36.28	-
280	N-linked_Glycosylation	AIVTVDTNGSGAEVD EEEEEECCCCCCEEE	37.86	-
330	N-linked_Glycosylation	AEHPHGFNISLQTHS CCCCCCEEEEEEECC	27.77	-
459	N-linked_Glycosylation	NNHAPVFNRSSYEGT CCCCCCCCCCCCEEC	43.06	-
568	N-linked_Glycosylation	QPMFEEVNCTVSLRQ CCCEEEECEEEEECC	21.01	-
627	N-linked_Glycosylation	SLKRSFMNLTAVRPT EECHHHHCCCEECCE	32.03	-
789	N-linked_Glycosylation	TTSFYVLNVTVYDLG CCEEEEEEEEEEECC	19.85	-
996	N-linked_Glycosylation	FERRAGYNLSFWASD CCHHCCCCEEEEECC	28.43	-
1175	N-linked_Glycosylation	SQGKLTFNLTSGNHL CCCEEEEEECCCCCC	36.85	-
1276	N-linked_Glycosylation	SDPDEGLNGSVTYSI CCCCCCCCCCEEEEE	52.10	-
1417	N-linked_Glycosylation	TRRKSSYNLTVEVTD CCCCCCCEEEEEEEC	31.05	-
1701	Phosphorylation	LREGNKDSVFSMNSY ECCCCCCCEEEECCC	27.03	16641100
1899	N-linked_Glycosylation	LTVQAEDNDSRVTYS EEEEEECCCCCEEEE	40.43	-
1998	N-linked_Glycosylation	GVHGNHLNDTLSYFL EEECCHHHHHHHHHC	32.44	-
2007	N-linked_Glycosylation	TLSYFLLNGTDLFHM HHHHHCCCCCCHHHH	54.16	-
2102	N-linked_Glycosylation	TDKDLGANGSVTYGF CCCCCCCCCEEEEEE	41.28	-
2165	N-linked_Glycosylation	EVHVTVRNKSNPLFQ EEEEEECCCCCCCCC	48.01	-
2183	N-linked_Glycosylation	YKVKVPENITLYTPI EEEECCCCEEEEECE	26.86	-
2325	N-linked_Glycosylation	VSKFFRINGSTGEIF CEEEEEECCCCCCEE	33.82	-
2368	N-linked_Glycosylation	GETLVVVNVSDINDN CCEEEEEEHHHCCCC	18.90	-
2387	N-linked_Glycosylation	REPQYEANVSELATC CCCCCCCCHHHHHHH	26.38	-
2430	N-linked_Glycosylation	QDRHFSINSTSGIIS CCCCEEEECCHHHHH	37.73	-
2470	N-linked_Glycosylation	ATVPVYINTTNANKY EEEEEEEECCCCCCC	24.14	-
2547	N-linked_Glycosylation	LQKLDRENSTERVIA ECCCCCCCCCCEEEE	55.94	-
2597	N-linked_Glycosylation	YTVSIPSNVSRDSPI EEEECCCCCCCCCCE	30.35	-
2910	Phosphorylation	DNPPRFASEDYRGSV CCCCCCCCCCCCCCE	28.43	16641100
3127	N-linked_Glycosylation	CDVAVFDNTTVKTPV CCEEEECCCCCCCCE	26.61	-
3278	N-linked_Glycosylation	HTGILYVNGSLDFET CCEEEEECCEECCCC	22.30	-
3312	N-linked_Glycosylation	DVTTIVINVTDVNEH CCEEEEEECCCCCCC	21.53	-
3432	N-linked_Glycosylation	PPRFFQLNYSTSVQE CCCEEEEECCCCCCC	20.23	-
3603	N-linked_Glycosylation	PHGRYSFNVTVSDGT CCCEEEEEEEEECCE	23.70	-
3770	N-linked_Glycosylation	PRHHLGRNCSCNGTT CCCCCCCCCCCCCEE	21.91	-
3774	N-linked_Glycosylation	LGRNCSCNGTTLRFS CCCCCCCCCEEEEEC	34.25	-
3815	N-linked_Glycosylation	WALLMFTNETASISL EEEEEECCCCCEEEE	33.10	-
3842	N-linked_Glycosylation	CPGGFYGNLSSRYPV CCCCCCCCCCCCEEC	25.93	-
3875	N-linked_Glycosylation	LLVDITDNASLVIPE EEEECCCCCCEECCH	23.84	-
3906	N-linked_Glycosylation	VPSNPSSNVSLGFEG CCCCCCCCCCCCCCC	31.56	-
3991	N-linked_Glycosylation	NCELGRENCTSAPCQ CCCCCCCCCCCCCCC	32.76	-
4168	Phosphorylation	HEPIIKRTWSGEELV CCCCEECCCCCCCCC	20.98	22673903
4170	Phosphorylation	PIIKRTWSGEELVYP CCEECCCCCCCCCCC	35.40	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAT2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAT2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAT2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of FAT2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.