CLCA1_HUMAN - dbPTM
CLCA1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLCA1_HUMAN
UniProt AC A8K7I4
Protein Name Calcium-activated chloride channel regulator 1
Gene Name CLCA1
Organism Homo sapiens (Human).
Sequence Length 914
Subcellular Localization Secreted, extracellular space . Cell membrane
Peripheral membrane protein
Extracellular side . Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
Protein Description May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC..
Protein Sequence MGPFKSSVFILILHLLEGALSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKKCQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMTTQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAASGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLIDAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIAKVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVASDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDLFIAIQAVDKVDLKSEISNIARVSLFIPPQTPPETPSPDETSAPCPNIHINSTIPGIHILKIMWKWIGELQLSIA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
58PhosphorylationQQIKDMVTQASLYLL
HHHHHHHHHHHHHHH		16.2727050516
68PhosphorylationSLYLLEATGKRFYFK
HHHHHHHHCCCEEEE		33.5829514088
91PhosphorylationTWKTKADYVRPKLET
CCCCCCHHHCCCCCH		11.8318083107
99PhosphorylationVRPKLETYKNADVLV
HCCCCCHHCCCCEEE		7.9018083107
147PhosphorylationAGKKLAEYGPQGRAF
CCHHHHHHCCCCCEE		28.62-
187S-nitrosylationGRIQAVRCSAGITGT
CCEEEEEECCCCCCC		2.3525040305
208AcetylationQGGSCYTKRCTFNKV
CCCCCEECCCCCCCC		20.997670207
216PhosphorylationRCTFNKVTGLYEKGC
CCCCCCCCCCHHCCC		24.0724719451
219PhosphorylationFNKVTGLYEKGCEFV
CCCCCCCHHCCCCEE		19.5524719451
232PhosphorylationFVLQSRQTEKASIMF
EEEEECCCCCHHHHH		38.0423403867
236PhosphorylationSRQTEKASIMFAQHV
ECCCCCHHHHHHHHH		26.1723403867
245PhosphorylationMFAQHVDSIVEFCTE
HHHHHHHHHHHHHHH		27.6923403867
285PhosphorylationDSEDFKKTTPMTTQP
CCHHHCCCCCCCCCC		36.4018785766
286PhosphorylationSEDFKKTTPMTTQPP
CHHHCCCCCCCCCCC		21.6824719451
290PhosphorylationKKTTPMTTQPPNPTF
CCCCCCCCCCCCCCE		32.5918785766
296PhosphorylationTTQPPNPTFSLLQIG
CCCCCCCCEEHEEEC		32.2818785766
308S-nitrosylationQIGQRIVCLVLDKSG
EECCEEEEEEECCCC		1.7025040305
383PhosphorylationPAAASGGTSICSGLR
CHHHHCCCCHHHHHH		20.6024719451
394PhosphorylationSGLRSAFTVIRKKYP
HHHHHHHEEEEECCC		18.1024719451
452PhosphorylationLEELSKMTGGLQTYA
HHHHHHHCCCCHHHC		31.6624043423
457PhosphorylationKMTGGLQTYASDQVQ
HHCCCCHHHCCHHHH		26.5424043423
458PhosphorylationMTGGLQTYASDQVQN
HCCCCHHHCCHHHHH		7.3724043423
460PhosphorylationGGLQTYASDQVQNNG
CCCHHHCCHHHHHCC		20.4024043423
476PhosphorylationIDAFGALSSGNGAVS
CCCCHHHHCCCCCCC		35.3524043423
477PhosphorylationDAFGALSSGNGAVSQ
CCCHHHHCCCCCCCH		36.8124043423
483PhosphorylationSSGNGAVSQRSIQLE
HCCCCCCCHHEEEEE		21.2424043423
503N-linked_GlycosylationLQNSQWMNGTVIVDS
EECCCCCCCEEEEEC		39.77UniProtKB CARBOHYD
566PhosphorylationAKVGTWKYSLQASSQ
EEEEEEEEEEEEECC		13.2325278378
567PhosphorylationKVGTWKYSLQASSQT
EEEEEEEEEEEECCE		15.4125278378
571PhosphorylationWKYSLQASSQTLTLT
EEEEEEEECCEEEEE		15.2625278378
572PhosphorylationKYSLQASSQTLTLTV
EEEEEEECCEEEEEE		30.1425278378
574PhosphorylationSLQASSQTLTLTVTS
EEEEECCEEEEEEEE		24.5325278378
576PhosphorylationQASSQTLTLTVTSRA
EEECCEEEEEEEECC		24.6225278378
578PhosphorylationSSQTLTLTVTSRASN
ECCEEEEEEEECCCC		19.2625278378
580PhosphorylationQTLTLTVTSRASNAT
CEEEEEEEECCCCCC		13.7825278378
581PhosphorylationTLTLTVTSRASNATL
EEEEEEEECCCCCCC		22.8525278378
584PhosphorylationLTVTSRASNATLPPI
EEEEECCCCCCCCCE		26.3625278378
585N-linked_GlycosylationTVTSRASNATLPPIT
EEEECCCCCCCCCEE		35.64UniProtKB CARBOHYD
587PhosphorylationTSRASNATLPPITVT
EECCCCCCCCCEEEE		44.0125278378
592PhosphorylationNATLPPITVTSKTNK
CCCCCCEEEEECCCC		24.4125278378
594PhosphorylationTLPPITVTSKTNKDT
CCCCEEEEECCCCCC		18.8225278378
595PhosphorylationLPPITVTSKTNKDTS
CCCEEEEECCCCCCC		32.9025278378
597PhosphorylationPITVTSKTNKDTSKF
CEEEEECCCCCCCCC		47.4725278378
619PhosphorylationANIRQGASPILRASV
EEECCCCCHHHHHHH		21.2122210691
637PhosphorylationIESVNGKTVTLELLD
HHHHCCEEEEEEEEC		21.8127794612
639PhosphorylationSVNGKTVTLELLDNG
HHCCEEEEEEEECCC		21.5327794612
652PhosphorylationNGAGADATKDDGVYS
CCCCCCCCCCCCCCE		35.2427794612
661PhosphorylationDDGVYSRYFTTYDTN
CCCCCEEEEEEEECC		10.19-
665PhosphorylationYSRYFTTYDTNGRYS
CEEEEEEEECCCCEE		20.08-
671PhosphorylationTYDTNGRYSVKVRAL
EEECCCCEEEEEEEE		21.15-
770N-linked_GlycosylationIHGGSLINLTWTAPG
EECCCEEEEEEECCC		36.39UniProtKB CARBOHYD
804N-linked_GlycosylationLDLRDKFNESLQVNT
HHHHHHHCCCCCEEC		43.62UniProtKB CARBOHYD
810N-linked_GlycosylationFNESLQVNTTALIPK
HCCCCCEECCEECCC		20.82UniProtKB CARBOHYD
831N-linked_GlycosylationVFLFKPENITFENGT
EEEECCCCEEEECCC		47.31UniProtKB CARBOHYD
836N-linked_GlycosylationPENITFENGTDLFIA
CCCEEEECCCEEEEE		55.24UniProtKB CARBOHYD
854PhosphorylationVDKVDLKSEISNIAR
ECCCCCCHHHCCCEE		47.6722798277
857PhosphorylationVDLKSEISNIARVSL
CCCCHHHCCCEEEEE		20.3822798277
890N-linked_GlycosylationPCPNIHINSTIPGIH
CCCCEEECCCCCCHH		20.95UniProtKB CARBOHYD
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CLCA1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLCA1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLCA1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KCMB1_HUMANKCNMB1physical
11994272
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D08275 Niflumic acid (INN); Niflugel (TN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLCA1_HUMAN

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Related Literatures of Post-Translational Modification

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