GRIP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRIP1_RAT
• UniProt AC: P97879
• Protein Name: Glutamate receptor-interacting protein 1
• Gene Name: Grip1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1112
• Subcellular Localization: Cytoplasm. Endomembrane system; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Endoplasmic reticulum membrane ; Peripheral membrane protein .
• Protein Description: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. [PubMed: 9069286 Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting]
• Protein Sequence: MIAVSFKCRCQILRRLTKDESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSIQGSSVMFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEATLLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSVCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHVKIQRSDRQLPWDPWASSQCSVHTNHHHNPHHPDHCRVPALGFPKALTPNSPPAMVSSSSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEANQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHSVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDSCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQPASSPKKLPIPSHSSDLGDGEEDPSPIQRPGKLSDVYPSTVPSVDSAVDSWDGSGIDARYGSQGTTFQTSGYNFNTYDWRSPKKRASLSPVPKPRSQTYPDVGLSNEDWDRSTASGFAGASDSADAEQEENFWSQALEDLETCGQSGILRELEATIMSGSTMSLNHEAPTARSQLGRQASFQERSNSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSGMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKSIEQPALPSDWSEQNSAFFQQPSHGGNLETREPTNTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	DESPYTKSASQTKPP CCCCCCCCCCCCCCC	25.92	25403869
43	Phosphorylation	ALAVRRQSIPEEFKG CEEEECCCCCHHHCC	38.00	23298284
430	Phosphorylation	TLPRSLYSTSPRGTM CCCHHHHCCCCCHHH	27.92	28432305
431	Phosphorylation	LPRSLYSTSPRGTMM CCHHHHCCCCCHHHH	29.24	28432305
432	Phosphorylation	PRSLYSTSPRGTMMR CHHHHCCCCCHHHHH	13.47	28432305
760	Phosphorylation	QTDAQPASSPKKLPI CCCCCCCCCCCCCCC	54.58	22108457
761	Phosphorylation	TDAQPASSPKKLPIP CCCCCCCCCCCCCCC	42.73	28432305
817	Phosphorylation	GSGIDARYGSQGTTF CCCCCCCCCCCCCEE	23.89	16641100
823	Phosphorylation	RYGSQGTTFQTSGYN CCCCCCCEEEECCCC	22.14	16641100
827	Phosphorylation	QGTTFQTSGYNFNTY CCCEEEECCCCCCCC	28.62	16641100
829	Phosphorylation	TTFQTSGYNFNTYDW CEEEECCCCCCCCCC	19.15	16641100
834	Phosphorylation	SGYNFNTYDWRSPKK CCCCCCCCCCCCCCC	18.02	16641100
846	Phosphorylation	PKKRASLSPVPKPRS CCCCCCCCCCCCCCC	22.74	30240740
912	Phosphorylation	ILRELEATIMSGSTM HHHHHHEEEECCCCE	14.08	27097102
915	Phosphorylation	ELEATIMSGSTMSLN HHHEEEECCCCEECC	26.24	28432305
917	Phosphorylation	EATIMSGSTMSLNHE HEEEECCCCEECCCC	17.40	27097102
918	Phosphorylation	ATIMSGSTMSLNHEA EEEECCCCEECCCCC	17.82	28432305
920	Phosphorylation	IMSGSTMSLNHEAPT EECCCCEECCCCCCC	26.55	28432305
927	Phosphorylation	SLNHEAPTARSQLGR ECCCCCCCHHHHHHH	41.57	27097102
937	Phosphorylation	SQLGRQASFQERSNS HHHHHHHHHHHHHCC	21.08	25403869
954	Phosphorylation	HYSQTTRSNTLPSDV CCCCCCCCCCCCCCC	31.88	22673903
956	Phosphorylation	SQTTRSNTLPSDVGR CCCCCCCCCCCCCCC	41.09	22108457
980	Phosphorylation	QEIKEIMSPTPVELH HHHHHHCCCCCCEEE	31.14	22108457
1076	Phosphorylation	NPLASQKSIEQPALP CCCCCCCCCCCCCCC	24.58	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRIP1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRIP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRIP1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GRIP1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.