ADCY8_HUMAN - dbPTM
ADCY8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADCY8_HUMAN
UniProt AC P40145
Protein Name Adenylate cyclase type 8
Gene Name ADCY8
Organism Homo sapiens (Human).
Sequence Length 1251
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity)..
Protein Sequence MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MELSDVRCLTG
----CCCCCCEECCC		37.0350563707
55MethylationQRFIHGHRGGSGSGS
CCCCCCCCCCCCCCC		56.62-
148PhosphorylationFFLNGGYSYRGVIFP
CCCCCCCCCCCEECH		16.1924719451
406PhosphorylationQHQFHRIYIHRYENV
HHHHHEEEEEEECCE		7.2222817900
410PhosphorylationHRIYIHRYENVSILF
HEEEEEEECCEEEEE		9.5522817900
500PhosphorylationIRYVRSRTKHDVDMR
HHHHHHCCCCCCCCE		33.7024719451
584PhosphorylationLRKHNIETYLIKQPE
HHHCCCEEEEECCCC		21.6030619164
585PhosphorylationRKHNIETYLIKQPED
HHCCCEEEEECCCCC		8.1430619164
607PhosphorylationDIVKESVSSSDRRNS
HHHHHHCCCCCCCCC		33.1425332170
614PhosphorylationSSSDRRNSGATFTEG
CCCCCCCCCCCCCCC		28.1728348404
624PhosphorylationTFTEGSWSPELPFDN
CCCCCCCCCCCCCCC		15.36-
646PhosphorylationLAALTRNSINLLPNH
HHHHHHHHHHCCHHH		15.0122210691
662PhosphorylationAQALHVQSGPEEINK
HHHHHHCCCHHHHHH		56.0522210691
674PhosphorylationINKRIEHTIDLRSGD
HHHHHHEEECCCCCC		11.9122210691
746PhosphorylationMPMTIQFSILIMLHS
CCCHHHHHHHHHHHH		10.5024719451
759PhosphorylationHSALVLITTAEDYKC
HHHHHHHHCCCCCCH		18.7824719451
764PhosphorylationLITTAEDYKCLPLIL
HHHCCCCCCHHHHHH		8.6324719451
817N-linked_GlycosylationDKSIPLKNLTFNSSA
CCCCCCCCCEECCCC		52.58UniProtKB CARBOHYD
821N-linked_GlycosylationPLKNLTFNSSAVFTD
CCCCCEECCCCHHCC		29.80UniProtKB CARBOHYD
888N-linked_GlycosylationFLRYDNLNHSGEDFL
HHCCCCCCCCCCCCC		33.27UniProtKB CARBOHYD
1108PhosphorylationIGAKKPQYDIWGKTV
CCCCCCCCCCCCCEE		20.2325690035
1154PhosphorylationFDYRGEIYVKGISEQ
EEECCEEEEEECCCC		7.5722817900
1159PhosphorylationEIYVKGISEQEGKIK
EEEEEECCCCCCEEE		41.7318669648
1229PhosphorylationKGHYNRRTLLSPSGT
CCCCCCCEEECCCCC		28.9027174698
1232PhosphorylationYNRRTLLSPSGTEPG
CCCCEEECCCCCCCC		21.8227174698
1234PhosphorylationRRTLLSPSGTEPGAQ
CCEEECCCCCCCCCC		55.7827174698
1236PhosphorylationTLLSPSGTEPGAQAE
EEECCCCCCCCCCCC		43.2627174698
1245PhosphorylationPGAQAEGTDKSDLP-
CCCCCCCCCCCCCC-		31.5970959601
1248PhosphorylationQAEGTDKSDLP----
CCCCCCCCCCC----		47.3827174698
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADCY8_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADCY8_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADCY8_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ADCY8_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D01697 Colforsin daropate hydrochloride (JAN); Nkh 477; Adehl (TN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADCY8_HUMAN

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Related Literatures of Post-Translational Modification

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