FKBP8_MOUSE - dbPTM
FKBP8_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FKBP8_MOUSE
UniProt AC O35465
Protein Name Peptidyl-prolyl cis-trans isomerase FKBP8
Gene Name Fkbp8
Organism Mus musculus (Mouse).
Sequence Length 402
Subcellular Localization Mitochondrion membrane
Single-pass membrane protein
Cytoplasmic side .
Protein Description Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development..
Protein Sequence MASWAEPSEPAALRLPGAPLLEGFEVLDGVDDAEEEDDLSGLPPLEDMGQPTVEEAEQPGALAREFLAATEPEPAPAPAPEEWLDILGNGLLRMKTLVPGPKGSSRPLKGQVVTVHLQMSLENGTRVQEEPELAFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGRSPYIPPHAALCLEVTLKTAEDGPDLEMLSGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSNTKVDMTCEEEEELLQLKVKCLNNLAASQLKLDHYRAALRSCSQVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKRAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGGVALSVVIAARN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MASWAEPSEP
-----CCCCCCCCCC		26.0628066266
102UbiquitinationKTLVPGPKGSSRPLK
EEECCCCCCCCCCCC		76.8622790023
102 (in isoform 2)Ubiquitination-76.8622790023
147UbiquitinationCDVIQALDLSVPLMD
CHHHHHEECCCEECC		39.6627667366
261UbiquitinationEEELLQLKVKCLNNL
HHHHHHHHHHHHHHH		27.0422790023
261 (in isoform 2)Ubiquitination-27.0422790023
262 (in isoform 2)Ubiquitination-7.81-
263MalonylationELLQLKVKCLNNLAA
HHHHHHHHHHHHHHH		31.2732601280
274UbiquitinationNLAASQLKLDHYRAA
HHHHHHHCHHHHHHH		44.2022790023
274 (in isoform 2)Ubiquitination-44.2022790023
275 (in isoform 2)Ubiquitination-7.16-
284PhosphorylationHYRAALRSCSQVLEH
HHHHHHHHHHHHHHH		20.9725266776
285S-palmitoylationYRAALRSCSQVLEHQ
HHHHHHHHHHHHHHC		2.3928526873
286PhosphorylationRAALRSCSQVLEHQP
HHHHHHHHHHHHHCC		25.2725266776
297 (in isoform 2)Ubiquitination-45.3422790023
297UbiquitinationEHQPDNIKALFRKGK
HHCCCCHHHHHHHCC		45.34-
297MalonylationEHQPDNIKALFRKGK
HHCCCCHHHHHHHCC		45.3426320211
298 (in isoform 2)Ubiquitination-14.24-
304 (in isoform 2)Ubiquitination-36.7922790023
304UbiquitinationKALFRKGKVLAQQGE
HHHHHHCCEEEECCC		36.79-
304MalonylationKALFRKGKVLAQQGE
HHHHHHCCEEEECCC		36.7932601280
305 (in isoform 2)Ubiquitination-7.94-
313PhosphorylationLAQQGEYSEAIPILR
EEECCCHHHHHHHHH		19.0928066266
324 (in isoform 2)Ubiquitination-46.1822790023
324MalonylationPILRAALKLEPSNKT
HHHHHHHCCCCCCCC		46.1832601280
324UbiquitinationPILRAALKLEPSNKT
HHHHHHHCCCCCCCC		46.18-
325 (in isoform 2)Ubiquitination-14.06-
330UbiquitinationLKLEPSNKTIHAELS
HCCCCCCCCHHHHHH		53.8722790023
330 (in isoform 2)Ubiquitination-53.8722790023
331 (in isoform 2)Ubiquitination-23.42-
348PhosphorylationKKRAAQRSTETALYR
HHHHHHHHHHHHHHH		20.6525159016
349PhosphorylationKRAAQRSTETALYRK
HHHHHHHHHHHHHHH		39.2728066266
351PhosphorylationAAQRSTETALYRKML
HHHHHHHHHHHHHHH		23.2728066266
354PhosphorylationRSTETALYRKMLGNP
HHHHHHHHHHHHCCH		13.0125159016
356UbiquitinationTETALYRKMLGNPSR
HHHHHHHHHHCCHHH		25.5627667366
357UbiquitinationETALYRKMLGNPSRL
HHHHHHHHHCCHHHC		4.2427667366
401UbiquitinationLSVVIAARN------
HHHHHHCCC------		40.1327667366
402UbiquitinationSVVIAARN-------
HHHHHCCC-------		52.0627667366
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FKBP8_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FKBP8_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FKBP8_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FKBP8_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FKBP8_MOUSE

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Related Literatures of Post-Translational Modification

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