dbPTM

PKHA6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PKHA6_HUMAN
UniProt AC	Q9Y2H5
Protein Name	Pleckstrin homology domain-containing family A member 6
Gene Name	PLEKHA6
Organism	Homo sapiens (Human).
Sequence Length	1048
Subcellular Localization
Protein Description
Protein Sequence	MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYTMRV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSNKTGGKRPAT ---CCCCCCCCCCCC	56.25	29759185
24	Phosphorylation	IPNHNMVSEVPPERP CCCCCCCCCCCCCCC	23.31	29449344
32	Phosphorylation	EVPPERPSVRATRTA CCCCCCCCHHHHHHH	30.38	29449344
36	Phosphorylation	ERPSVRATRTARKAV CCCCHHHHHHHHHHH	20.28	22210691
38	Phosphorylation	PSVRATRTARKAVAF CCHHHHHHHHHHHHH	26.85	22210691
41	Methylation	RATRTARKAVAFGKR HHHHHHHHHHHHCCC	44.76	100290719
51	Phosphorylation	AFGKRSHSMKRNPNA HHCCCCCCCCCCCCC	27.52	24719451
108	Phosphorylation	LGSIPLLSFRVAAVQ HCCCCEEEEEEEEEC	20.77	24719451
117	Phosphorylation	RVAAVQPSDNISRKH EEEEECCCCCCCCCC	26.63	25072903
121	Phosphorylation	VQPSDNISRKHTFKA ECCCCCCCCCCCEEE	41.34	25072903
197	Phosphorylation	HQQPPHNSLPKPEPE CCCCCCCCCCCCCCC	42.91	23927012
247	Phosphorylation	PAGPEPASEPGSPYP CCCCCCCCCCCCCCC	55.85	23927012
251	Phosphorylation	EPASEPGSPYPEGPR CCCCCCCCCCCCCCC	31.79	23927012
253	Phosphorylation	ASEPGSPYPEGPRVP CCCCCCCCCCCCCCC	18.66	23927012
274	Phosphorylation	AQPNGWQYHSPSRPG CCCCCCCCCCCCCCC	9.58	28985074
276	Phosphorylation	PNGWQYHSPSRPGST CCCCCCCCCCCCCCC	21.45	24275748
278	Phosphorylation	GWQYHSPSRPGSTAF CCCCCCCCCCCCCCC	54.87	24275748
282	Phosphorylation	HSPSRPGSTAFPSQD CCCCCCCCCCCCCCC	21.17	27732954
283	Phosphorylation	SPSRPGSTAFPSQDG CCCCCCCCCCCCCCC	37.93	27732954
287	Phosphorylation	PGSTAFPSQDGETGG CCCCCCCCCCCCCCC	34.15	27732954
292	Phosphorylation	FPSQDGETGGHRRSF CCCCCCCCCCCCCCC	54.73	27794612
298	Phosphorylation	ETGGHRRSFPPRTNP CCCCCCCCCCCCCCH	41.90	24670416
307	Ubiquitination	PPRTNPDKIAQRKSS CCCCCHHHHHHCHHH	40.99	29967540
313	Phosphorylation	DKIAQRKSSMNQLQQ HHHHHCHHHHHHHHH	36.69	26657352
314	Phosphorylation	KIAQRKSSMNQLQQW HHHHCHHHHHHHHHH	25.45	25394399
336	Phosphorylation	PPPEDLRSPSRFYPV CCCHHHCCCCCCCCC	34.23	28985074
338	Phosphorylation	PEDLRSPSRFYPVSR CHHHCCCCCCCCCCC	35.95	26657352
344	Phosphorylation	PSRFYPVSRRVPEYY CCCCCCCCCCCCCHH	15.18	24719451
350	Phosphorylation	VSRRVPEYYGPYSSQ CCCCCCCHHCCCCCC	13.98	20736484
358	Phosphorylation	YGPYSSQYPDDYQYY HCCCCCCCCCCCCCC	15.58	26356563
362	Phosphorylation	SSQYPDDYQYYPPGV CCCCCCCCCCCCCCC	13.04	27259358
364	Phosphorylation	QYPDDYQYYPPGVRP CCCCCCCCCCCCCCH	16.23	26356563
365	Phosphorylation	YPDDYQYYPPGVRPE CCCCCCCCCCCCCHH	6.34	26356563
373	Phosphorylation	PPGVRPESICSMPAY CCCCCHHHHCCCCCC	31.42	26356563
376	Phosphorylation	VRPESICSMPAYDRI CCHHHHCCCCCCCCC	26.57	25849741
380	Phosphorylation	SICSMPAYDRISPPW HHCCCCCCCCCCCCC	10.41	29978859
384	Phosphorylation	MPAYDRISPPWALED CCCCCCCCCCCHHHH	26.29	21815630
404	Phosphorylation	RNGGGPAYQLREWKE HCCCCCHHHCCCCCC	15.94	-
426	Phosphorylation	DATVWIPSPSRQPVY CCEEEECCCCCCCCC	26.78	21815630
428	Phosphorylation	TVWIPSPSRQPVYYD EEEECCCCCCCCCHH	48.13	21815630
433	Phosphorylation	SPSRQPVYYDELDAA CCCCCCCCHHHHHHH	16.34	23927012
434	Phosphorylation	PSRQPVYYDELDAAS CCCCCCCHHHHHHHH	11.81	25106551
441	Phosphorylation	YDELDAASSSLRRLS HHHHHHHHHHHHHHC	23.37	23927012
442	Phosphorylation	DELDAASSSLRRLSL HHHHHHHHHHHHHCC	28.76	25849741
443	Phosphorylation	ELDAASSSLRRLSLQ HHHHHHHHHHHHCCC	24.33	23927012
448	Phosphorylation	SSSLRRLSLQPRSHS HHHHHHHCCCCCCCC	24.13	23927012
453	Phosphorylation	RLSLQPRSHSVPRSP HHCCCCCCCCCCCCC	27.14	25394399
455	Phosphorylation	SLQPRSHSVPRSPSQ CCCCCCCCCCCCCCC	34.75	17001009
459	Phosphorylation	RSHSVPRSPSQGSYS CCCCCCCCCCCCCCC	23.88	30278072
461	Phosphorylation	HSVPRSPSQGSYSRA CCCCCCCCCCCCCCE	48.71	23927012
464	Phosphorylation	PRSPSQGSYSRARIY CCCCCCCCCCCEEEE	16.58	28152594
465	Phosphorylation	RSPSQGSYSRARIYS CCCCCCCCCCEEEEC	14.70	28152594
466	Phosphorylation	SPSQGSYSRARIYSP CCCCCCCCCEEEECC	22.59	28152594
471	Phosphorylation	SYSRARIYSPVRSPS CCCCEEEECCCCCCC	11.02	25394399
472	Phosphorylation	YSRARIYSPVRSPSA CCCEEEECCCCCCCC	17.97	23927012
476	Phosphorylation	RIYSPVRSPSARFER EEECCCCCCCCCCCC	24.36	23927012
478	Phosphorylation	YSPVRSPSARFERLP ECCCCCCCCCCCCCC	33.07	23927012
488	Phosphorylation	FERLPPRSEDIYADP CCCCCCCCCCCCCCH	45.45	21945579
492	Phosphorylation	PPRSEDIYADPAAYV CCCCCCCCCCHHHHH	19.78	21945579
498	Phosphorylation	IYADPAAYVMRRSIS CCCCHHHHHHHHCCC	9.26	27259358
503	Phosphorylation	AAYVMRRSISSPKVP HHHHHHHCCCCCCCC	19.23	18669648
505	Phosphorylation	YVMRRSISSPKVPPY HHHHHCCCCCCCCCC	41.66	23927012
506	Phosphorylation	VMRRSISSPKVPPYP HHHHCCCCCCCCCCC	27.37	25394399
512	Phosphorylation	SSPKVPPYPEVFRDS CCCCCCCCCHHHHHH	13.12	27251275
532	Ubiquitination	LNEQDTDKLLGKLCE CCHHHHHHHHHHHHH	47.94	29967540
568	Phosphorylation	LESALMGTHQELEMF HHHHHHHHHHHHHHH	13.35	29759185
577	Phosphorylation	QELEMFGSQPAYPEK HHHHHHCCCCCCHHH	23.02	28348404
591	Phosphorylation	KLRHKKDSLQNQLIN HHHCCCHHHHHHHHH	40.51	26657352
677	Methylation	GTDTAKHRGGLGPSA CCCCCCCCCCCCCCC	39.92	115487835
683	Phosphorylation	HRGGLGPSATYSSNS CCCCCCCCCCCCCCC	31.29	28857561
685	Phosphorylation	GGLGPSATYSSNSPA CCCCCCCCCCCCCCC	28.42	28857561
686	Phosphorylation	GLGPSATYSSNSPAS CCCCCCCCCCCCCCC	15.15	25884760
687	Phosphorylation	LGPSATYSSNSPASP CCCCCCCCCCCCCCC	20.77	28348404
688	Phosphorylation	GPSATYSSNSPASPL CCCCCCCCCCCCCCC	30.80	28857561
690	Phosphorylation	SATYSSNSPASPLSS CCCCCCCCCCCCCCC	24.64	28857561
693	Phosphorylation	YSSNSPASPLSSASL CCCCCCCCCCCCCCC	29.74	26657352
696	Phosphorylation	NSPASPLSSASLTSP CCCCCCCCCCCCCCC	27.52	28857561
697	Phosphorylation	SPASPLSSASLTSPL CCCCCCCCCCCCCCC	29.56	27251275
699	Phosphorylation	ASPLSSASLTSPLSP CCCCCCCCCCCCCCC	33.84	28348404
711	Phosphorylation	LSPFSLVSGSQGSPT CCCCCCCCCCCCCCC	37.71	28348404
713	Phosphorylation	PFSLVSGSQGSPTKP CCCCCCCCCCCCCCC	24.70	28857561
716	Phosphorylation	LVSGSQGSPTKPGSN CCCCCCCCCCCCCCC	23.04	26657352
744	Phosphorylation	HQTLPLDTPRDISLV CCCCCCCCCCCCCCC	28.10	23312004
749	Phosphorylation	LDTPRDISLVPTRQE CCCCCCCCCCCCHHH	27.83	24275569
775	Phosphorylation	VGVVPPRTKSPTDDE CCCCCCCCCCCCCCC	41.47	30266825
777	Phosphorylation	VVPPRTKSPTDDEVT CCCCCCCCCCCCCCC	32.21	23927012
779	Phosphorylation	PPRTKSPTDDEVTPS CCCCCCCCCCCCCHH	64.27	23927012
784	Phosphorylation	SPTDDEVTPSAVVRR CCCCCCCCHHHHHHH	14.96	23927012
786	Phosphorylation	TDDEVTPSAVVRRNA CCCCCCHHHHHHHCC	25.08	23403867
794	Phosphorylation	AVVRRNASGLTNGLS HHHHHCCCCCCCCCC	37.57	26657352
797	Phosphorylation	RRNASGLTNGLSSQE HHCCCCCCCCCCCCC	30.66	23312004
801	Phosphorylation	SGLTNGLSSQERPKS CCCCCCCCCCCCCCC	31.23	23312004
802	Phosphorylation	GLTNGLSSQERPKSA CCCCCCCCCCCCCCC	40.89	23312004
808	Phosphorylation	SSQERPKSAVFPGEG CCCCCCCCCCCCCCC	32.14	23927012
816	Ubiquitination	AVFPGEGKVKMSVEE CCCCCCCCCCCCHHH	34.09	32142685
833	Phosphorylation	DRMRRHQSGSMREKR HHHHHHCCCCHHHHH	27.06	24275569
835	Phosphorylation	MRRHQSGSMREKRRS HHHHCCCCHHHHHHH	21.66	24275569
842	Phosphorylation	SMREKRRSLQLPASP CHHHHHHHCCCCCCC	25.21	30266825
848	Phosphorylation	RSLQLPASPAPDPSP HHCCCCCCCCCCCCC	21.47	23927012
854	Phosphorylation	ASPAPDPSPRPAYKV CCCCCCCCCCHHHHH	40.70	23927012
859	Phosphorylation	DPSPRPAYKVVRRHR CCCCCHHHHHHHCCC	13.65	23927012
867	Phosphorylation	KVVRRHRSIHEVDIS HHHHCCCCCEEEECC	23.36	23927012
874	Phosphorylation	SIHEVDISNLEAALR CCEEEECCHHHHHHH	30.79	30278072
890	Phosphorylation	EEPGGHAYETPREEI CCCCCCCCCCCHHHH	18.05	25394399
919	Phosphorylation	VDINKELSTPDKVLI CCCCCCCCCCCEEEC	38.70	30242111
920	Phosphorylation	DINKELSTPDKVLIP CCCCCCCCCCEEECC	48.40	26657352
923	Ubiquitination	KELSTPDKVLIPERY CCCCCCCEEECCCCC	39.89	29967540
930	Phosphorylation	KVLIPERYIDLEPDT EEECCCCCCCCCCCC	9.34	26356563
937	Phosphorylation	YIDLEPDTPLSPEEL CCCCCCCCCCCHHHH	36.52	22199227
940	Phosphorylation	LEPDTPLSPEELKEK CCCCCCCCHHHHHHH	31.31	28355574
945	Ubiquitination	PLSPEELKEKQKKVE CCCHHHHHHHHHHHH	67.17	29967540
956	Phosphorylation	KKVERIKTLIAKSSM HHHHHHHHHHHHHHC	22.48	28857561
961	Phosphorylation	IKTLIAKSSMQNVVP HHHHHHHHHCCCCCC	23.24	28857561
962	Phosphorylation	KTLIAKSSMQNVVPI HHHHHHHHCCCCCCC	24.55	24719451
974	Phosphorylation	VPIGEGDSVDVPQDS CCCCCCCCCCCCCCC	30.95	24719451
983	Phosphorylation	DVPQDSESQLQEQEK CCCCCCHHHHHHHHH	39.89	22617229
1010	Phosphorylation	SRRGRMLSVQCATPS HHCCCEEEEEECCCC	10.78	23927012
1015	Phosphorylation	MLSVQCATPSPPTSP EEEEEECCCCCCCCC	31.74	23663014
1017	Phosphorylation	SVQCATPSPPTSPAS EEEECCCCCCCCCCC	38.87	23927012
1020	Phosphorylation	CATPSPPTSPASPAP ECCCCCCCCCCCCCC	51.21	23927012
1021	Phosphorylation	ATPSPPTSPASPAPP CCCCCCCCCCCCCCC	25.00	23663014
1024	Phosphorylation	SPPTSPASPAPPANP CCCCCCCCCCCCCCC	25.61	23663014
1033	Phosphorylation	APPANPLSSESPRGA CCCCCCCCCCCCCCC	33.06	23927012
1034	Phosphorylation	PPANPLSSESPRGAD CCCCCCCCCCCCCCC	50.18	23927012
1036	Phosphorylation	ANPLSSESPRGADSS CCCCCCCCCCCCCCC	23.11	23927012
1043	Phosphorylation	SPRGADSSYTMRV-- CCCCCCCCCCCCC--	25.77	21815630
1044	Phosphorylation	PRGADSSYTMRV--- CCCCCCCCCCCC---	14.43	27259358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PKHA6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PKHA6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PKHA6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PKHA6_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PKHA6_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-472; SER-476 ANDSER-867, AND MASS SPECTROMETRY.	18669648 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-848 AND SER-854, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-492, AND MASSSPECTROMETRY.	17389395 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-492, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Time-resolved mass spectrometry of tyrosine phosphorylation sites inthe epidermal growth factor receptor signaling network reveals dynamicmodules."; Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J.,Lauffenburger D.A., White F.M.; Mol. Cell. Proteomics 4:1240-1250(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-492, AND MASSSPECTROMETRY.	15951569 [Abstract]