PLD2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLD2_RAT
• UniProt AC: P70498
• Protein Name: Phospholipase D2
• Gene Name: Pld2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 933
• Subcellular Localization: Membrane; Peripheral membrane protein.
• Protein Description: May have a role in signal-induced cytoskeletal regulation and/or endocytosis..
• Protein Sequence: MTVTQTDLFPYGDYLNSSQLHMEPDVVDTLKEGEDPADRMHPFLAIYDLQPLRAHPLVFAPGVPVIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTTKKKFRHFQELHRDLQRHKVLMSLLNLARFAAAHSPAREAANENIPSLPRGGSEGSARHTASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGSKGLEGVIRKRSGGHRVPGFTCCGRDQVCYRWSKRWLVVKDSFLLYMRPETGAISFVQLFDPGFEVQVGKRSTEARYGVRIDTSHRSLILKCSSYRQARWWGQEITELAQGPGRDFLQLHQHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAREEIFITDWWLSPEIYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRTLMLLHPNIKVMRHPDLVTLWAHHEKLLVVDQAVAFLGGLDLAYGRWDDVQYRLTDLGDPSESADSQTPTPGSDPAATPDLSHNHFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGVAARDLARHFIQRWNFTKTIKARYKIPQYPYLLPKSASTANHLPFIIPGGQCATVQVLRSVDRWSAGTLESSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHEQGQCFRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYMSICGLRTHGELGGHPISELIYIHSKLLIADDRTVIIGSANINDRSLLGKRDSELAILIKDTEMEPSLMDGVEYQAGRFALSLRGRCFSVILGANTWPDLDLRDPVCDDFFQLWQETAENNATIYEQIFRCLPSNATRSLRALREYVAVESLATVSPSLAQSELAHIRGHLVHFPLKFLEDESLLPHWGAKRGMIPLEVWT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	TQTDLFPYGDYLNSS CCCCCCCCHHCCCHH	18.46	-
134	Phosphorylation	ARFAAAHSPAREAAN HHHHHHCCHHHHHHH	18.61	30240740
146	Phosphorylation	AANENIPSLPRGGSE HHHCCCCCCCCCCCC	47.40	22108457
223	S-palmitoylation	HRVPGFTCCGRDQVC CCCCCEEEECCCCEE	1.85	11923096
224	S-palmitoylation	RVPGFTCCGRDQVCY CCCCEEEECCCCEEH	4.56	11923096

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLD2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLD2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLD2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTB_RAT	Actb	physical	11373276
SYUA_HUMAN	SNCA	physical	20664530
FAK2_RAT	Ptk2b	physical	15705590

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.