| UniProt ID | PCD15_MOUSE | |
|---|---|---|
| UniProt AC | Q99PJ1 | |
| Protein Name | Protocadherin-15 | |
| Gene Name | Pcdh15 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1943 | |
| Subcellular Localization |
Cell membrane Single-pass membrane protein . Efficient localization to the plasma membrane requires the presence of LHFPL5. Isoform 1: Cell membrane Single-pass type I membrane protein. Isoform 2: Cell membrane Single-pass type I membrane prote |
|
| Protein Description | Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.. | |
| Protein Sequence | MFLQFAVWKCLPHGILIASLLVVSWGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRLNYEDKTRYYVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPILVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFASLHIEILDENNQSPYFTMPSYQGYILESAPVGATISESLNLTTPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTPTGITRYLTLLQPVDREEQQTYTFLITAFDGVQESEPVVVNIRVMDANDNTPTFPEISYDVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGGKGDFVINKTTGLVSIAPGVELIVGQTYALTVQASDNAPPAERRHSICTVYIEVLPPNNQSPPRFPQLMYSLEVSEAMRIGAILLNLQATDREGDPITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLPAGTSFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGMPASRVRYRVDDVQFPYPASIFDVEEDSGRVVTRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVRILVLHPGEIPRFTQEEYRPPPVSELAARGTVVGVISAAAINQSIVYSIVAGNEEDKFGINNVTGVIYVNSPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENDHPPVFQKKFYIGGVSEDARMFASVLRVKATDRDTGNYSAMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAYSLEDYSKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQSAMPAAKPAAPVPAAPAPPPPPPPPPPGAHLYEELGESAMHNLFLLYHFEQSRGNNSVPEDRSSHRDGMAFSSSTTESHEPAHVEGPLKESQPNPARTFSFVPDEDNLSTHNPLYMESIGQRSTNSDLQPRTDFEELLAPRTQVKSQSLRGPREKIQRVWNQSVSFPRRLMWKAPNRPETIDLVEWQITNQRAECESARCHPSQRGSSNVLLATEDAHESEKEGGHRDTLIVQQTEQLKSLSSGSSFSSSWSHFSFSTLPTISRAVELGSEPNVVTSPADCTLELSPPLRPRILNSLSSKRETPTCASDTEPKRNSFEIAPHPPSISAPLPHPPLPRPPIAFTTFPLPLSPPNPPPPQLVTFSLPISTPPTSSLPLPPPLSLPPPPRPPAPRLFPQPPSTSIPSTDSISAPAAKCTASATHARETTSTTQPPASNPQWGAEPHRHPKGILRHVKNLAELEKSVSNMYSHIEKNCPPADPSKLHTFCPAEKTGMKITHDQSQETLVRVVEGIDVQPHSQSTSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 55 | Phosphorylation | IVAIDEESRNGTILV EEEECCCCCCCEEEE | 29.06 | - | |
| 57 | N-linked_Glycosylation | AIDEESRNGTILVDN EECCCCCCCEEEEEC | 62.33 | - | |
| 59 | Phosphorylation | DEESRNGTILVDNML CCCCCCCEEEEECEE | 18.06 | - | |
| 68 | Ubiquitination | LVDNMLIKGTAGGPD EEECEEEECCCCCCC | 46.37 | - | |
| 77 | Phosphorylation | TAGGPDPTIELSLKD CCCCCCCCEEEECCC | 34.17 | - | |
| 102 | N-linked_Glycosylation | VKQMLFLNSTGRVLD HHHHHCCCCCCCCCC | 30.14 | - | |
| 151 | Phosphorylation | DRNDNSPTFKHESYY CCCCCCCCCCCCEEE | 45.17 | 29899451 | |
| 206 | N-linked_Glycosylation | NPEDPTSNDTFEIPL CCCCCCCCCCEEEEE | 55.61 | - | |
| 231 | Phosphorylation | RLNYEDKTRYYVIIQ ECCCCCCCCEEEEEE | 35.90 | 21454597 | |
| 233 | Phosphorylation | NYEDKTRYYVIIQAN CCCCCCCEEEEEECC | 13.81 | 21454597 | |
| 234 | Phosphorylation | YEDKTRYYVIIQAND CCCCCCEEEEEECCH | 5.06 | 21454597 | |
| 302 (in isoform 20) | Phosphorylation | - | 33.64 | 26643407 | |
| 424 | N-linked_Glycosylation | ATISESLNLTTPLRI CCHHHCCCCCCCEEE | 44.62 | - | |
| 564 | N-linked_Glycosylation | GKGDFVINKTTGLVS CCCCEEEECCCCCCE | 30.25 | - | |
| 602 (in isoform 23) | Phosphorylation | - | 19.97 | 25777480 | |
| 604 (in isoform 23) | Phosphorylation | - | 2.06 | 25777480 | |
| 606 (in isoform 23) | Phosphorylation | - | 3.82 | 25777480 | |
| 667 | N-linked_Glycosylation | GDPQRVFNLSETTGI CCCCEEEECCHHCCC | 39.54 | - | |
| 729 | N-linked_Glycosylation | FDPYLPRNLSVVEEE CCCCCCCCCCHHHHH | 34.43 | - | |
| 773 | N-linked_Glycosylation | NLFRITSNGSIYTAV CCEEECCCCCEEEEE | 39.31 | - | |
| 777 | Phosphorylation | ITSNGSIYTAVKLNR ECCCCCEEEEEECCH | 7.14 | - | |
| 778 | Phosphorylation | TSNGSIYTAVKLNRE CCCCCEEEEEECCHH | 24.25 | - | |
| 826 | N-linked_Glycosylation | DNSPVFTNSTYTVVV CCCCCEECCEEEEEE | 22.38 | - | |
| 856 | N-linked_Glycosylation | KDVDLGANVSYRIRS EECCCCCCEEEEECC | 22.82 | - | |
| 946 | Acetylation | MVAPDAVKGTPITTV CCCCCCCCCCCCEEE | 59.80 | 7614541 | |
| 1069 | N-linked_Glycosylation | VISAAAINQSIVYSI EEEHHHHCCHHEEEE | 25.48 | - | |
| 1089 | N-linked_Glycosylation | EDKFGINNVTGVIYV CCCCCCCCCCEEEEE | 30.70 | - | |
| 1123 (in isoform 22) | Phosphorylation | - | 24.99 | 25777480 | |
| 1125 (in isoform 22) | Phosphorylation | - | 37.80 | 25777480 | |
| 1127 (in isoform 22) | Phosphorylation | - | 29.61 | 25777480 | |
| 1128 | Phosphorylation | LANLRVPSKSNTAKV EEECCCCCCCCCEEE | 45.95 | 28542873 | |
| 1128 (in isoform 21) | Phosphorylation | - | 45.95 | 25777480 | |
| 1130 (in isoform 21) | Phosphorylation | - | 43.69 | 25777480 | |
| 1132 (in isoform 21) | Phosphorylation | - | 34.64 | 25777480 | |
| 1180 | N-linked_Glycosylation | ATDRDTGNYSAMAYR ECCCCCCCEEEEEEE | 29.67 | - | |
| 1422 | Phosphorylation | TKTARIQSAMPAAKP CCCHHHHHCCCCCCC | 24.94 | 25367039 | |
| 1453 | Phosphorylation | PPPGAHLYEELGESA CCCCCCHHHHHHHHH | 9.48 | 25367039 | |
| 1459 | Phosphorylation | LYEELGESAMHNLFL HHHHHHHHHHHHHHH | 29.15 | 25367039 | |
| 1468 | Phosphorylation | MHNLFLLYHFEQSRG HHHHHHHHHCHHHCC | 13.45 | 25367039 | |
| 1473 | Phosphorylation | LLYHFEQSRGNNSVP HHHHCHHHCCCCCCC | 34.65 | 25367039 | |
| 1493 | Phosphorylation | HRDGMAFSSSTTESH CCCCCCCCCCCCCCC | 17.53 | 17242355 | |
| 1497 | Phosphorylation | MAFSSSTTESHEPAH CCCCCCCCCCCCCCC | 37.12 | 17242355 | |
| 1546 (in isoform 10) | Methylation | - | 34.47 | - | |
| 1564 (in isoform 26) | Phosphorylation | - | 41.75 | 26643407 | |
| 1564 (in isoform 19) | Phosphorylation | - | 41.75 | 26643407 | |
| 1569 (in isoform 18) | Phosphorylation | - | 27.42 | 26643407 | |
| 1610 | Phosphorylation | DLVEWQITNQRAECE EEEEEEECCCHHHHH | 15.36 | 21454597 | |
| 1885 | Phosphorylation | AELEKSVSNMYSHIE HHHHHHHHHHHHHHH | 23.99 | 25338131 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCD15_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCD15_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCD15_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PCD15_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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