TCPA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCPA_RAT
• UniProt AC: P28480
• Protein Name: T-complex protein 1 subunit alpha
• Gene Name: Tcp1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 556
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
• Protein Description: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity)..
• Protein Sequence: MEGPLSVFGDRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYINENLIINTDELGRDCLINAAKTSMSSKIIGINGDFFANMVVDAVLAVKYTDIRGQPRYPVNSVNILKAHGRSQIESMLINGYALNCVVGSQGMLKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGASILSTLANLEGEETFEATMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVHGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHPESKDDKHGGYENAVHSGALDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGPLSVF -------CCCCCCCC	14.00	-
6	Phosphorylation	--MEGPLSVFGDRST --CCCCCCCCCCCCH	20.66	-
115	Phosphorylation	VKQKIHPTSVISGYR HHCCCCCCCHHCHHH	22.82	25575281
116	Phosphorylation	KQKIHPTSVISGYRL HCCCCCCCHHCHHHH	23.16	25575281
119	Phosphorylation	IHPTSVISGYRLACK CCCCCHHCHHHHHHH	27.84	25575281
121	Phosphorylation	PTSVISGYRLACKEA CCCHHCHHHHHHHHH	8.82	25575281
126	Ubiquitination	SGYRLACKEAVRYIN CHHHHHHHHHHHHHH	43.00	-
181	Phosphorylation	DAVLAVKYTDIRGQP HHHEEEEEECCCCCC	11.75	-
199	Acetylation	VNSVNILKAHGRSQI CCCHHHHHHCCCHHH	34.24	22902405
240	Phosphorylation	KIACLDFSLQKTKMK HHHHHHHHCHHCCCC	29.56	25575281
371	Phosphorylation	IKNTKARTSASIILR EECCCCCCCCHHHHC	33.24	23984901
372	Phosphorylation	KNTKARTSASIILRG ECCCCCCCCHHHHCC	17.92	23984901
374	Phosphorylation	TKARTSASIILRGAN CCCCCCCHHHHCCCC	15.21	23984901
400	Acetylation	HDALCVVKRVLESKS HHHHHHHHHHHHCCC	19.18	25786129
466	Acetylation	DSTDLVAKLRAFHNE CCHHHHHHHHHHHHH	30.90	22902405
484	Acetylation	NPERKNLKWIGLDLV CCCCCCCEEEEEEEE	46.27	22902405
494	Acetylation	GLDLVHGKPRDNKQA EEEEECCCCCCCCCC	23.23	22902405
538	Acetylation	IKLHPESKDDKHGGY HHHCCCCCCCCCCCC	69.18	22902405
538	Ubiquitination	IKLHPESKDDKHGGY HHHCCCCCCCCCCCC	69.18	-
541	Acetylation	HPESKDDKHGGYENA CCCCCCCCCCCCCCC	55.04	22902405
541	Ubiquitination	HPESKDDKHGGYENA CCCCCCCCCCCCCCC	55.04	-
545	Phosphorylation	KDDKHGGYENAVHSG CCCCCCCCCCCCCCC	15.59	25575281
551	Phosphorylation	GYENAVHSGALDD-- CCCCCCCCCCCCC--	21.11	29779826

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCPA_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCPA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCPA_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TCPA_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.