AT2A3_MOUSE - dbPTM
AT2A3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT2A3_MOUSE
UniProt AC Q64518
Protein Name Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Gene Name Atp2a3
Organism Mus musculus (Mouse).
Sequence Length 1038
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein . Sarcoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction..
Protein Sequence MEEAHLLSAADVLRRFSVTAEGGLSLEQVTDARERYGPNELPTEEGKSLWELVVEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTDAIPDPRAVNQDKKNMLFSGTNIASGKALGVAVATGLQTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEAEAGTCRLHEFTISGTTYTPEGEVRQGEQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLKGLSRVERAGACNSVIKQLMRKEFTLEFSRDRKSMSVYCTPTRADPKVQGSKMFVKGAPESVIERCSSVRVGSRTAPLSTTSREHILAKIRDWGSGSDTLRCLALATRDTPPRKEDMHLDDCSRFVQYETDLTFVGCVGMLDPPRPEVAACITRCSRAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVLGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRNPREALISGWLFFRYLAIGVYVGLATVAAATWWFLYDTEGPQVTFYQLRNFLKCSEDNPLFAGIDCKVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWLNPWLLGAVVMSMALHFLILLVPPLPLIFQVTPLSGRQWGVVLQMSLPVILLDEALKYLSRNHMDGVLGTFMQARSRQLPTTSRTPYHTGKKGPEVNPGSRGESPVWPSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEEAHLLS
-------CCHHHHHH		44.84-
17PhosphorylationADVLRRFSVTAEGGL
HHHHHHCCCCCCCCC		19.4225266776
19PhosphorylationVLRRFSVTAEGGLSL
HHHHCCCCCCCCCCH		20.1425266776
25PhosphorylationVTAEGGLSLEQVTDA
CCCCCCCCHHHHCCH		32.8925266776
122PhosphorylationAIEALKEYEPEMGKV
HHHHHHHHCHHHHCH		34.8928464351
158UbiquitinationVEVAVGDKVPADLRL
EEEECCCCCCCCEEE		44.1622790023
335PhosphorylationRKNAIVRSLPSVETL
HHCCHHHCCCCCCCC		33.4628464351
338PhosphorylationAIVRSLPSVETLGCT
CHHHCCCCCCCCCCC		37.5722210690
341PhosphorylationRSLPSVETLGCTSVI
HCCCCCCCCCCCEEE		26.7128464351
345PhosphorylationSVETLGCTSVICSDK
CCCCCCCCEEEEECC		24.9922871156
346PhosphorylationVETLGCTSVICSDKT
CCCCCCCEEEEECCC		17.3528542873
350PhosphorylationGCTSVICSDKTGTLT
CCCEEEEECCCCCCC		30.9022871156
357PhosphorylationSDKTGTLTTNQMSVC
ECCCCCCCCCCCCEE		24.4421082442
358PhosphorylationDKTGTLTTNQMSVCR
CCCCCCCCCCCCEEE		26.9421082442
415PhosphorylationDGLVELATICALCND
CHHHHHHHHHHHHCC		29.2521183079
427PhosphorylationCNDSALDYNEAKGVY
HCCCCCCHHHHCCHH		18.76-
441PhosphorylationYEKVGEATETALTCL
HHHHHHHHHHHHHHH		29.5727149854
443PhosphorylationKVGEATETALTCLVE
HHHHHHHHHHHHHHH		23.7023140645
446PhosphorylationEATETALTCLVEKMN
HHHHHHHHHHHHHHC		11.0022324799
481UbiquitinationVIKQLMRKEFTLEFS
HHHHHHCCCCEEEEE		43.12-
484PhosphorylationQLMRKEFTLEFSRDR
HHHCCCCEEEEECCC		26.8624899341
488PhosphorylationKEFTLEFSRDRKSMS
CCCEEEEECCCCCEE		24.7223737553
497PhosphorylationDRKSMSVYCTPTRAD
CCCCEEEEECCCCCC		5.36-
499PhosphorylationKSMSVYCTPTRADPK
CCEEEEECCCCCCCC		15.26-
540PhosphorylationRTAPLSTTSREHILA
CCCCCCCCCHHHHHH		23.5528059163
541PhosphorylationTAPLSTTSREHILAK
CCCCCCCCHHHHHHH		35.4428059163
569PhosphorylationLALATRDTPPRKEDM
HHHHCCCCCCCCCCC		31.7228542873
612PhosphorylationPEVAACITRCSRAGI
HHHHHHHHHHHCCCC		26.05-
615PhosphorylationAACITRCSRAGIRVV
HHHHHHHHCCCCEEE		23.13-
662PhosphorylationGREFDDLSPEQQRQA
CCCCCCCCHHHHHHH		33.1327566939
685PhosphorylationRVEPAHKSRIVENLQ
HCCHHHHHHHHHHHH		19.8528059163
713UbiquitinationNDAPALKKAEIGIAM
CCCHHHHHCCCEEEE		52.6922790023
722PhosphorylationEIGIAMGSGTAVAKS
CCEEEECCCHHHHHH		21.6428542873
758UbiquitinationRAIYNNMKQFIRYLI
HHHHHCHHHHHHHHH		44.15-
1009PhosphorylationARSRQLPTTSRTPYH
HHHCCCCCCCCCCCC		46.10-
1032PhosphorylationNPGSRGESPVWPSD-
CCCCCCCCCCCCCC-		27.8130482847
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AT2A3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AT2A3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT2A3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AT2A3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AT2A3_MOUSE

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Related Literatures of Post-Translational Modification

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