dbPTM

PCDB8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PCDB8_HUMAN
UniProt AC	Q9UN66
Protein Name	Protocadherin beta-8 {ECO:0000305}
Gene Name	PCDHB8 {ECO:0000312\|HGNC:HGNC:8693}
Organism	Homo sapiens (Human).
Sequence Length	801
Subcellular Localization	Cell membrane Single-pass type I membrane protein .
Protein Description	Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain..
Protein Sequence	MEASGKLICRQRQVLFSFLLLGLSLAGAAEPRSYSVVEETEGSSFVTNLAKDLGLEQREFSRRGVRVVSRGNKLHLQLNQETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQMLVKVSESSPPGTAFPLKNAEDLDIGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVVDVNDNAPEFEQPFYRVQISEDSPISFLVVKVSATDVDTGVNGEISYSLFQASDEISKTFKVDFLTGEIRLKKQLDFEKFQSYEVNIEARDAGGFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPETVVALFSVSDLDSGENGKISCSIQEDLPFLLKSSVGNFYTLLTETPLDRESRAEYNVTITVTDLGTPRLTTHLNMTVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINTDNGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEPPCSATATLHLLLVDGFSQPYLPLPEAAPAQGQADSLTVYLVVALASVSSLFLFSVLLFVAVLLCRRSRAASVGRCSVPEGPFPGHLVDVRGTGSLSQNYQYEVCLAGGSGTNEFQFLKPVLPNIQGHSFGPEMEQNSNFRNGFGFSLQLK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
192	Phosphorylation	KRSDGRKYPELVLDK ECCCCCCCCHHHHHH	10.69	19658100
279	Phosphorylation	TGVNGEISYSLFQAS CCCCCEEEEEEEECC	12.36	22210691
281	Phosphorylation	VNGEISYSLFQASDE CCCEEEEEEEECCCH	18.86	22210691
418	Phosphorylation	DRESRAEYNVTITVT CCCCCCEEEEEEEEE	17.59	24719451
419	N-linked_Glycosylation	RESRAEYNVTITVTD CCCCCEEEEEEEEEC	18.89	UniProtKB CARBOHYD
429	Phosphorylation	ITVTDLGTPRLTTHL EEEECCCCCCEEEEE	16.72	24719451
437	N-linked_Glycosylation	PRLTTHLNMTVLVSD CCEEEEECEEEEEEC	19.24	UniProtKB CARBOHYD
509	Phosphorylation	ASLVSINTDNGHLFA EEEEEEECCCCCEEE	29.22	-
568	N-linked_Glycosylation	FVLYPLQNGSAPCTE EEEEECCCCCCCCCC	54.81	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PCDB8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PCDB8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PCDB8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PCDB8_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PCDB8_HUMAN

Related Literatures of Post-Translational Modification