ESYT1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ESYT1_RAT
• UniProt AC: Q9Z1X1
• Protein Name: Extended synaptotagmin-1
• Gene Name: Esyt1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1088
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein. Localizes primarily to the endoplasmic reticulum. Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in respon
• Protein Description: Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity)..
• Protein Sequence: MERSPEEGAGPEPSGQSPATDSTRERDGGSGVPPAGPGAASEALAVLTSFGRRLLVLVPVYLAGAAGLSVGFVLFGLALYLGWRRVRDGKERSLRAARQLLDDEERITAETLYMSHRELPAWVSFPDVEKAEWLNKIVVQVWPFLGQYMEKLLAETVAPAVRGANPHLQTFTFTRVELGEKPVRIIGVKVHPSQRKDQILLDLNVSYVGDLQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPIVGAVSMFFIKRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRVGTQTFCSRVIDEELNPHWGETYEVIVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQAGVLDNWYPLQGGQGQVHLRLEWLSLLPDAEKLDQVLQWNRGITSRPEPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSVQDVTQESKATYSTNCPVWEEAFRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQWFQLSSSGPNSRLYMKLVMRILYLDSSEMRLPTEPGAQDWDSESPETGSSVDAPPRPYHTTPNSHFGTENVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGRSLRTHVVREDLNPRWNEVFEVIVTSIPGQELDIEVFDKDLDKDDFLGRYKVGLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLSPRPTAAELEEVLQVNSLIQTQKSSELAAALLSVYLERSEDLPLRKGTKPPSPYAILTVGETSHKTKTVSQTSAPIWEESASFLIRKPHAESLELQVRGEGTGTLGSISLPLSELLQEEQLCLDRWFALSGQGQVLMRVQLGILVSQHSGVEAHSHSSSSLNEEPEVLGDPTHTASPVLEVRHRLTHGDSPSEALIGPLGQVKLTVWYHSDEQKLISIIHSCRALRQNGRDLPDPYVSVLLLPDKNRGTKRKTSQKKRTLNPEFNERFEWDLPLDGTLRRKLDVSVKSNSSFMSRERELLGKVQLDLAEIDLSQGAAQWYDLIDDRDKGGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MERSPEEG -------CCCCCCCC	42.26	-
14	Phosphorylation	EGAGPEPSGQSPATD CCCCCCCCCCCCCCC	48.04	22108457
17	Phosphorylation	GPEPSGQSPATDSTR CCCCCCCCCCCCCCC	21.74	22108457
22	Phosphorylation	GQSPATDSTRERDGG CCCCCCCCCCCCCCC	25.63	22108457
113	Phosphorylation	RITAETLYMSHRELP HHCHHHHHHHCCCCC	12.18	21940666
115	Phosphorylation	TAETLYMSHRELPAW CHHHHHHHCCCCCCC	13.06	22108457
316	Phosphorylation	QDVAQLRSPLPRGII HHHHHHCCCCCCHHH	39.10	-
341	Ubiquitination	SSKDKYVKGLIEGKS CCCCHHHHHHCCCCC	44.93	-
409	Acetylation	DDFLGRMKLDVGKVL CCCCCCCCCCHHHHE	39.93	22902405
589	Phosphorylation	KLVMRILYLDSSEMR HHHHHHHHCCCCCCC	13.19	25575281
592	Phosphorylation	MRILYLDSSEMRLPT HHHHHCCCCCCCCCC	26.13	25575281
593	Phosphorylation	RILYLDSSEMRLPTE HHHHCCCCCCCCCCC	34.77	25575281
660	Acetylation	RFLGGLVKGKSDPYV CCCCHHCCCCCCCCE	66.71	22902405
666	Phosphorylation	VKGKSDPYVKLKVAG CCCCCCCCEEEEECC	18.40	-
806	Acetylation	LPLRKGTKPPSPYAI CCCCCCCCCCCCEEE	64.70	22902405
809	Phosphorylation	RKGTKPPSPYAILTV CCCCCCCCCEEEEEE	38.78	-
811	Phosphorylation	GTKPPSPYAILTVGE CCCCCCCEEEEEECC	15.60	-
933	Phosphorylation	GDPTHTASPVLEVRH CCCCCCCCCEEEEEE	19.39	-
943	Phosphorylation	LEVRHRLTHGDSPSE EEEEEHHCCCCCHHH	24.62	22673903
947	Phosphorylation	HRLTHGDSPSEALIG EHHCCCCCHHHEEEC	34.61	22108457
949	Phosphorylation	LTHGDSPSEALIGPL HCCCCCHHHEEECCC	39.18	28432305
993	Phosphorylation	GRDLPDPYVSVLLLP CCCCCCCCEEEEECC	16.85	22108457
995	Phosphorylation	DLPDPYVSVLLLPDK CCCCCCEEEEECCCC	10.95	30181290
1051	Phosphorylation	KSNSSFMSRERELLG CCCCCCHHHHHHHHH	29.04	22108457

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
316	S	Phosphorylation	Kinase	CDK5	Q03114	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ESYT1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ESYT1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ESYT1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.