HSPB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSPB2_HUMAN
• UniProt AC: Q16082
• Protein Name: Heat shock protein beta-2
• Gene Name: HSPB2
• Organism: Homo sapiens (Human).
• Sequence Length: 182
• Subcellular Localization: Cytoplasm . Nucleus . Localizes to nuclear foci.
• Protein Description: May regulate the kinase DMPK..
• Protein Sequence: MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEILTPTLYHGYYVRPRAAPAGEGSRAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSREFCRTYVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEEAAIVEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGRSVPHA ------CCCCCCCCC	42.80	24043423
5	Phosphorylation	---MSGRSVPHAHPA ---CCCCCCCCCCCC	43.45	24719451
13	Phosphorylation	VPHAHPATAEYEFAN CCCCCCCCCEEEECC	25.19	24043423
16	Phosphorylation	AHPATAEYEFANPSR CCCCCCEEEECCHHH	17.55	24043423
22	Phosphorylation	EYEFANPSRLGEQRF EEEECCHHHHCCCCC	39.69	24719451
44	Phosphorylation	EILTPTLYHGYYVRP HHCCCCEECCEEECC	8.83	-
52	Methylation	HGYYVRPRAAPAGEG CCEEECCCCCCCCCC	32.58	24387967
60	Phosphorylation	AAPAGEGSRAGASEL CCCCCCCCCCCCCEE	18.04	26437602
61	Methylation	APAGEGSRAGASELR CCCCCCCCCCCCEEE	48.15	24387977
65	Phosphorylation	EGSRAGASELRLSEG CCCCCCCCEEECCCC	35.92	29743597
70	Phosphorylation	GASELRLSEGKFQAF CCCEEECCCCCEEEE	37.56	26437602
92	Phosphorylation	PDEVTVRTVDNLLEV CCCEEEEEHHHHHHH	28.07	26437602
100	Phosphorylation	VDNLLEVSARHPQRL HHHHHHHHHHCCHHH	15.37	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSPB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSPB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSPB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSPB8_HUMAN	HSPB8	physical	14594798
DMPK_HUMAN	DMPK	physical	9490724
CRYAB_HUMAN	CRYAB	physical	10625651
HSPB2_HUMAN	HSPB2	physical	10625651
HSPB3_HUMAN	HSPB3	physical	10625651
TRAF6_HUMAN	TRAF6	physical	18950704
ANDR_HUMAN	AR	physical	17974989
UBC9_HUMAN	UBE2I	physical	19597476
HSF1_HUMAN	HSF1	physical	19597476
IF4E_HUMAN	EIF4E	physical	20101233
TNFA_HUMAN	TNF	physical	21245386
UBC9_HUMAN	UBE2I	physical	23155000
ACTS_HUMAN	ACTA1	physical	26465331
ACTB_HUMAN	ACTB	physical	26465331
ACTC_HUMAN	ACTC1	physical	26465331
ACTG_HUMAN	ACTG1	physical	26465331
CAZA2_HUMAN	CAPZA2	physical	26465331
CMYA5_HUMAN	CMYA5	physical	26465331
PGS1_HUMAN	BGN	physical	26465331
DCTN1_HUMAN	DCTN1	physical	26465331
ENOB_HUMAN	ENO3	physical	26465331
FLNC_HUMAN	FLNC	physical	26465331
MYPC3_HUMAN	MYBPC3	physical	26465331
MYH6_HUMAN	MYH6	physical	26465331
MYOM2_HUMAN	MYOM2	physical	26465331
RYR2_HUMAN	RYR2	physical	26465331
TELT_HUMAN	TCAP	physical	26465331
TITIN_HUMAN	TTN	physical	26465331
TNNI3_HUMAN	TNNI3	physical	26465331
WDR1_HUMAN	WDR1	physical	26465331
THIM_HUMAN	ACAA2	physical	26465331
ALDH2_HUMAN	ALDH2	physical	26465331
ALDOA_HUMAN	ALDOA	physical	26465331
ATPA_HUMAN	ATP5A1	physical	26465331
CP1B1_HUMAN	CYP1B1	physical	26465331
ENOA_HUMAN	ENO1	physical	26465331
ETFA_HUMAN	ETFA	physical	26465331
G3P_HUMAN	GAPDH	physical	26465331
ECHB_HUMAN	HADHB	physical	26465331
MCCB_HUMAN	MCCC2	physical	26465331
MDHC_HUMAN	MDH1	physical	26465331
COX1_HUMAN	COX1	physical	26465331
COX3_HUMAN	COX3	physical	26465331
NDUA6_HUMAN	NDUFA6	physical	26465331
NDUAD_HUMAN	NDUFA13	physical	26465331
PGM1_HUMAN	PGM1	physical	26465331
SDHA_HUMAN	SDHA	physical	26465331
AGA11_HUMAN	AGAP11	physical	26465331
DDIT4_HUMAN	DDIT4	physical	26465331
DUS1_HUMAN	DUSP1	physical	26465331
FHL2_HUMAN	FHL2	physical	26465331
MYOZ2_HUMAN	MYOZ2	physical	26465331
PARVA_HUMAN	PARVA	physical	26465331
ZN335_HUMAN	ZNF335	physical	26465331
BEX4_HUMAN	BEX4	physical	26465331
EF1A1_HUMAN	EEF1A1	physical	26465331
IF4A2_HUMAN	EIF4A2	physical	26465331
GARS_HUMAN	GARS	physical	26465331
SYNC_HUMAN	NARS	physical	26465331
NH2L1_HUMAN	NHP2L1	physical	26465331
RL11_HUMAN	RPL11	physical	26465331
RL36A_HUMAN	RPL36A	physical	26465331
RL36L_HUMAN	RPL36AL	physical	26465331
RS11_HUMAN	RPS11	physical	26465331
THUM2_HUMAN	THUMPD2	physical	26465331
ABCC9_HUMAN	ABCC9	physical	26465331
ABCD4_HUMAN	ABCD4	physical	26465331
VATE1_HUMAN	ATP6V1E1	physical	26465331
MYG_HUMAN	MB	physical	26465331
PPM1K_HUMAN	PPM1K	physical	26465331
SDF2_HUMAN	SDF2	physical	26465331
GTR1_HUMAN	SLC2A1	physical	26465331
A2MG_HUMAN	A2M	physical	26465331
CATB_HUMAN	CTSB	physical	26465331
CATD_HUMAN	CTSD	physical	26465331
KCRM_HUMAN	CKM	physical	26465331
TATD1_HUMAN	TATDN1	physical	26465331
B2MG_HUMAN	B2M	physical	26465331
C1QA_HUMAN	C1QA	physical	26465331
THMS2_HUMAN	THEMIS2	physical	26465331
LEG1_HUMAN	LGALS1	physical	26465331
PKP2_HUMAN	PKP2	physical	26465331
ASAH1_HUMAN	ASAH1	physical	26465331
TXNIP_HUMAN	TXNIP	physical	26465331
HSPB2_HUMAN	HSPB2	physical	26465331
CRYAB_HUMAN	CRYAB	physical	26465331
DCTN6_HUMAN	DCTN6	physical	26465331
MLF2_HUMAN	MLF2	physical	26465331
NT5D2_HUMAN	NT5DC2	physical	26465331
COX2_HUMAN	COX2	physical	26465331

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.