THMS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THMS2_HUMAN
• UniProt AC: Q5TEJ8
• Protein Name: Protein THEMIS2
• Gene Name: THEMIS2
• Organism: Homo sapiens (Human).
• Sequence Length: 643
• Protein Description: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production..
• Protein Sequence: MEPVPLQDFVRALDPASLPRVLRVCSGVYFEGSIYEISGNECCLSTGDLIKVTQVRLQKVVCENPKTSQTMELAPNFQGYFTPLNTPQSYETLEELVSATTQSSKQLPTCFMSTHRIVTEGRVVTEDQLLMLEAVVMHLGIRSARCVLGMEGQQVILHLPLSQKGPFWTWEPSAPRTLLQVLQDPALKDLVLTCPTLPWHSLILRPQYEIQAIMHMRRTIVKIPSTLEVDVEDVTASSRHVHFIKPLLLSEVLAWEGPFPLSMEILEVPEGRPIFLSPWVGSLQKGQRLCVYGLASPPWRVLASSKGRKVPRHFLVSGGYQGKLRRRPREFPTAYDLLGAFQPGRPLRVVATKDCEGEREENPEFTSLAVGDRLEVLGPGQAHGAQGSDVDVLVCQRLSDQAGEDEEEECKEEAESPERVLLPFHFPGSFVEEMSDSRRYSLADLTAQFSLPCEVKVVAKDTSHPTDPLTSFLGLRLEEKITEPFLVVSLDSEPGMCFEIPPRWLDLTVVKAKGQPDLPEGSLPIATVEELTDTFYYRLRKLPACEIQAPPPRPPKNQGLSKQRRHSSEGGVKSSQVLGLQQHARLPKPKAKTLPEFIKDGSSTYSKIPAHRKGHRPAKPQRQDLDDDEHDYEEILEQFQKTI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	VRALDPASLPRVLRV HHHCCHHHHHHHHHH	44.27	24719451
59	Ubiquitination	VTQVRLQKVVCENPK EEEEEEEEEEECCCC	41.02	-
143	Phosphorylation	VMHLGIRSARCVLGM HHHHHHHHHHEEECC	20.39	-
164	Ubiquitination	LHLPLSQKGPFWTWE EECCCCCCCCCCCCC	66.24	-
222	Ubiquitination	HMRRTIVKIPSTLEV HHHHHEEECCCCEEE	45.08	-
225	Phosphorylation	RTIVKIPSTLEVDVE HHEEECCCCEEECHH	49.44	30108239
226	Phosphorylation	TIVKIPSTLEVDVED HEEECCCCEEECHHH	22.91	30108239
366	Phosphorylation	REENPEFTSLAVGDR CCCCCCCCEEEECCC	22.59	-
367	Phosphorylation	EENPEFTSLAVGDRL CCCCCCCEEEECCCE	21.47	-
411	Ubiquitination	EDEEEECKEEAESPE CCHHHHHHHHHCCCC	62.97	-
416	Phosphorylation	ECKEEAESPERVLLP HHHHHHCCCCEEEEE	38.82	23401153
440	Phosphorylation	EMSDSRRYSLADLTA HCCCCCCEEHHHHHH	13.61	22461510
441	Phosphorylation	MSDSRRYSLADLTAQ CCCCCCEEHHHHHHC	18.44	26657352
567	Phosphorylation	LSKQRRHSSEGGVKS CCCCCCCCCCCCCCH	28.42	28985074
568	Phosphorylation	SKQRRHSSEGGVKSS CCCCCCCCCCCCCHH	33.85	26699800
593	Phosphorylation	LPKPKAKTLPEFIKD CCCCCCCCCCHHHHC	53.02	28450419
602	Phosphorylation	PEFIKDGSSTYSKIP CHHHHCCCCCCCCCC	29.64	28857561
603	Phosphorylation	EFIKDGSSTYSKIPA HHHHCCCCCCCCCCH	36.57	29978859
604	Phosphorylation	FIKDGSSTYSKIPAH HHHCCCCCCCCCCHH	33.25	29978859
605	Phosphorylation	IKDGSSTYSKIPAHR HHCCCCCCCCCCHHC	15.20	29978859
606	Phosphorylation	KDGSSTYSKIPAHRK HCCCCCCCCCCHHCC	24.97	29978859
632	Phosphorylation	LDDDEHDYEEILEQF CCCCCCCHHHHHHHH	19.85	25587033

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THMS2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THMS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THMS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.